Paper - Advancing Protein Structure Analysis For Drug Development | |
In a paper at JoVE, James Sandy et al. delineate the procedures for employing the Crystallization Facility at Harwell and the VMXi beamline at Diamond Light Source for robotic protein crystallization and in situ room-temperature data collection. This approach allows for the determination of high-quality room-temperature crystal structures and offers prompt feedback on crystallization trial outcomes. The system is globally accessible through multiple modes of access, enabling remote setup and imaging of crystallization experiments, with automatic crystal identification using a machine learning tool. (Our In Situ-1 Crystallization Plates are used at these facilities) | |
GloCube Plus Glow Discharge System For TEM Grids | | |
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The GloQube™ Plus is the first-of-its-kind compact, easy to use, stand-alone glow discharge system.
The primary application of GloQube™ Plus is the hydrophilization (wetting) of carbon-coated TEM support films and grids, which otherwise tend to be hydrophobic. Glow discharge treatment with air makes film surfaces negatively charged and hydrophilic and allows the easy spread of aqueous solutions. This and other processes are outlined below.
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LAAAMP - Fast Team Grants | | |
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Applications are now being accepted for FAST Team grants. These grants are designed to enhance advanced light source (AdLS) and crystallography sciences in eight world regions.
"The successful applicants will spend two (2) months during the Calendar Year 2025 at LAAAMP’s AdLS Collaborative Partners to acquire expertise in accelerator technology or AdLS beamline techniques, including those involving crystallography." IUPAP, IUCr, and ICTP will award the grants. The deadline to apply is October 31st, 2024.
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Did you know we offer a wide range of crystallization screens? Our screens are designed for efficient and flexible screening of crystallization conditions for proteins, nucleic acids, macromolecular complexes, water-soluble small molecules, membrane proteins, and more!
Screens are available in various volumes and configurations, including 96-well plates and 10 mL kits. Brand names include Jena Bioscience, Molecular Dimensions, Rigaku, and Polyvalan.
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NIH Common Fund Cryo-EM Service Centers | | |
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Have you visited the shared website for the NIH Common Fund Transformative High Resolution Cryo-Electron Microscopy Program Centers? Service centers across the United States provide access to cryoEM and cryoET instrumentation and training and development services. The website Cryoemcenters.org provides "an overview of the different centers to help you navigate these resources and links to each of the center's own websites for more information." | |
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The 81st Pittsburgh Diffraction Conference (PDC) will be held from September 21st to the 23rd in Ithaca, NY, at CHESS. The conference will discuss progress in fundamental and applied diffraction and
crystallographic research, ranging from materials discovery for functional devices to targeting viruses for drug development. Includes lectures, posters, vendor exhibits, and more. We are a sponsor of and exhibitor at the PDC.
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The New York City Integrative Structural Biology Symposium (NYC-ISB24) is from October 9th to the 11th in New York City. The symposium topics will cover the best practices and current research toward building structural models across different resolution scales. A workshop is included whose focus is to understand the challenges and opportunities of applying integrative structural biology techniques to one’s research. We are a sponsor of and exhibitor at the NYC-ISB24. | |
Events, Workshops and Conferences | | |
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If you are looking for more events, please visit our events page. It lists conferences, workshops, symposiums, user meetings, and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research, and more.
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Industry Resources and News | |
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Here is a small selection of industry resources and news for your browsing.
- Paper at Acta Cryst D, A snapshot love story: what serial crystallography has done and will do for us - Learn More
- Paper at Acta Cryst D, Managing macromolecular crystallographic data with a laboratory information management system - Learn More
- Preprint at bioRxiv, Sensitive Detection of Structural Differences using a Statistical Framework for Comparative Crystallography - Learn More
- Paper at IUCrJ, Exploring serial crystallography for drug discovery - Learn More
- Article at MDPI Crystals, Natural Porous Carbon Derived from Popped Rice as Anode Materials for Lithium-Ion Batteries - Learn More
- Preprint at bioRxiv, Probing the modulation of enzyme kinetics by multi-temperature, time-resolved serial crystallography - Learn More
- Article at MDPI Crystals, Cocrystal Prediction Based on Deep Forest Model—A Case Study of Febuxostat - Learn More
- Paper at Acta Cryst F, Preparing research samples for safe arrival at centers and facilities: recipes for successful experiments - Learn More
- News announcement from Diamond Light Source, Accelerating structural biology: A new collaborative program grant for software development in structural biology announced with BBSRC - Learn More
- ResearchGate Announcement, ResearchGate and the International Union of Crystallography (IUCr) announce new Journal Home partnership for complete journals portfolio - Learn More
- Preprint at bioRxiv, Vesicle Picker: A tool for efficient identification of membrane protein complexes in vesicles - Learn More
- Preprint at bioRxiv, EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control - Learn More
- Paper at Acta Cryst D, Factors affecting macromolecule orientations in thin films formed in cryo-EM - Learn More
- Paper at the Journal of Microscopy, Creating and troubleshooting microscopy analysis workflows: Common challenges and common solutions - Learn More
- Paper at Acta Cryst D, Validation of electron-microscopy maps using solution small-angle X-ray scattering - Learn More
- Article at Advanced Photon Source, World’s first successful multi-bunch swap-out injection demonstrated at the Advanced Photon Source - Learn More
- Paper at Synchrotron JSR, BEATS: BEAmline for synchrotron X-ray microTomography at SESAME - Learn More
- Announcement from Advanced Light Source, New Proposal Writing Guidelines - Learn More
- Editorial at Appl Cryst JAC, Introduction to the virtual collection of papers on Artificial neural networks: applications in X-ray photon science and crystallography - Learn More
- Find beamline proposal deadlines from around the world at Lightsources.org - Learn More
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20th Anniversary - Product Commercialization and Licensing | |
This year, as we celebrate two decades of innovation, we're also proud to highlight the product commercialization and licensing that have fueled our success. Our journey at MiTeGen has been marked by bringing unique products to niche scientific markets, often made possible through strategic alliances. These collaborations have not only expanded our product portfolio but also accelerated the pace at which groundbreaking scientific tools reach the researchers who need them. As we look forward, we're eager to explore new partnerships. If you have a product idea that could benefit from our expertise in development and market access, we invite you to reach out. Let's collaborate to bring your vision to life and make a meaningful impact in the scientific community. | |
Have your lab be the first to know. Follow us on social media! | | | | |
