The Hyperpolarized MRI Technology Resource Center (HMTRC) is a National Center for Biomedical Imaging and Bioengineering (NCBIB) funded through the National Institute of Biomedical Imaging and Bioengineering (NIBIB) that focuses on the development and dissemination of new technology advances in hyperpolarization techniques, instrumentation, specialized data acquisition methodology, and analysis software for biomedical research. 

The April 2024 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Pre-clinical HP Chemistry Preps, Human HP Investigational Dose Formulation & Production, Clinical Translation Methods, Clinical Trial Research, and Analysis & Display Software.

The Hyperpolarized MRI Toolbox contains tools for hyperpolarized MRI Acquisition and reconstruction methods. The goal of this toolbox is to provide research-level and prototyping software tools for hyperpolarized MRI experiments. It is currently based on MATLAB code, and includes code for designing radiofrequency (RF) pulses, readout gradients, and data reconstruction.

Reference: Hyperpolarized ¹³C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco

SIVIC is an open-source, standards-based software framework and application suite for processing and visualization of DICOM MR Spectroscopy Data. Through use of DICOM, SIVIC aims to facilitate the application of MRS in medical imaging studies.

Hyperpolarized ¹³C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco

We’ve separated the HP MRI Toolbox & SIVIC resource links into separate sections to facilitate navigation of our tools. Also, added to the preclinical & human research sections is a new presentation by Dr. Peder Larson on “Storage, Visualization, and Analysis of Hyperpolarized C-13 MR Data” - a sneak peak of one of the presentations given in the 2023 HP MRI Course that will be released later this Fall!

This hyperpolarized agent DICOM tool allows for a set of DICOM attributes to store HP C-13 MRI metadata such as those which are related to the hyperpolarized agent including the agent information, dose, and timing. The basic workflow of the python script created using the package PyDICOM is as follows: (1) User input is required for the parameter of a directory path that leads to a folder containing the DICOM images or a single DICOM image. The contents of the said folder are then sorted in numerical order. (2) The user will provide their input for each attribute, by adding their own value or choosing from a list of default variable that will then be assigned to the attributes. (3) It will loop through the folder and add all the attributes to each DICOM file.

This tool has successfully been applied to demonstrations from a metabolite-specific EPI sequence on a GE 3T scanner, reconstructed with a custom implementation based on the GE Orchestra package, DICOM from Bruker 2D CSI scan generated by SIVIC, and a DICOM from a GE EPSI sequence generated by SIVIC.

Recent journal articles supported by the center

to inspire & drive your basic and clinical research

We are currently looking for presenters for our International HP C-13 MRI Seminar for January & February 2024. Present new findings, publications, or other work in preclinical and human research. Presentations are 25 minutes with a 5-minute Q &A. Email us at [email protected].

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The Hyperpolarized MRI Technology Resource Center (HMTRC) is supported by the National Institute of Biomedical Imaging and Bioengineering