Paper - Nucleating Agent Crystallophore Induces Instant Protein Crystallization | |
In a preprint at bioRxiv, Claude Sauter et al. discuss how TbXo4, a crystallophore, promotes protein-protein interactions and facilitates the rapid preparation of micro- and nano-crystals for serial crystallography. This lanthanide complex successfully nucleated hen egg white lysozyme crystallization in low salt conditions, as monitored by SAXS. The resulting crystals were used to determine the lysozyme-TbXo4 complex structure by SSX and 3D ED, demonstrating the potential effectiveness of crystallophores in sample preparation for serial crystallography. The manufacturer of TbXo4 recommends exploring the crystallophore nucleating agent at various concentrations to optimize your research since it's highly protein-dependent. If the protein tends to precipitate during screening, you can go down to 2mM; if, on the other hand, it is very stable in its buffer, you can go up to 20mM and more. | |
NIH Mature Synchrotron Resources | | |
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Do you have an interest in macromolecular crystallography (MX), small angle and wide angle X-ray scattering (SAXS and WAXS), fiber diffraction, and other synchrotron-based techniques that generate important structural biology data? Then, you will want to visit the NIGMS Mature Synchrotron Resource webpage.
You will learn how these resources provide state-of-the-art instrumentation, user support, and training. Information concerning how to apply for funding for an MSR is also included.
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Cryo-EM Vitrification Kit | | |
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The Cryo-EM V-Kit is a vitrification starter kit designed to facilitate the search for the optimal vitrification condition and cryo-EM grid for both soluble and membrane proteins.
It contains a variety of grids, surfactants, and a cryoprotectant. Surfactants are included to improve the quality of the vitrified ice by reducing surface tension and preventing proteins from adhering to the air-water interface. The kit includes detergents, such as Fluorinated Octyl Maltoside (FOM), which has been successfully used in determining high-resolution cryo-EM maps.
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Visit Us At The M&M Meeting In Cleveland | | |
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Are you attending the M&M meeting in Cleveland from July 28th to August 1st? Then, please stop by our booth #1536 to chat with us and see the latest tools and instruments for cryo-EM. You can learn how our products can help you achieve your research goals.
In addition, from 5:45 to 6:45 p.m., we will give a hands-on demonstration of the clipping station, manual plunge cooler and cryostat, and cryo-EM puck storage and shipping system. Stop by our booth to learn more, and contact us if you have a premeeting question.
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Custom Foam Dewars Made To Your Specifications | | |
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Ever wish you could have a custom foam dewar that fits your specific needs? You are in luck, as we now offer custom foam dewar design and manufacturing to your specifications. Our custom designed foam dewars offer a reliable and safe way to handle liquid nitrogen and other ultra-cold materials.
The process starts with you giving us general parameters for the custom design. We then work with you to create the final design. Once the design is agreed upon, we manufacture the end product.
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The 10th Structural Biology and Molecular Biophysics Workshop is August 1st in Omaha, Nebraska. It provides a forum for researchers working with proteins, nucleic acids, and other biomolecules using a variety of biophysical techniques. We are a sponsor of this event. | |
The 3rd Annual Early Career Symposium at IBBR is September 12th in Rockville, Maryland. The symposium provides a forum for graduate students and post-docs to share their exciting new scientific research in disease biology and biotherapeutics development and analysis. We are a sponsor of this event. | |
Events, Workshops and Conferences | | |
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If you are looking for more events, please visit our events page. It lists conferences, workshops, symposiums, user meetings, and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research, and more.
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Industry Resources and News | |
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Here is a small selection of industry resources and news for your browsing.
- Paper at IUCrJ, The evolution of raw data archiving and the growth of its importance in crystallography - Learn More
- Commentary at Acta Cryst C, Data collection is your last experiment - Learn More
- Paper at Crystal Growth & Design, Artificial Intelligence Assisted Pharmaceutical Crystallization - Learn More
- From Crystals MDPI, Special Issue on Nucleic Acid Crystallography - Learn More
- Video from the European Crystallographic Association, Women in Crystallography video series - Learn More
- Paper at Acta Cryst D, Deep-learning map segmentation for protein X-ray crystallographic structure determination - Learn More
- Editorial at Acta Cryst F, The importance of international collaborations in science and structural biology - Learn More
- Paper at Acta Cryst D, What shapes template-matching performance in cryogenic electron tomography in situ? - Learn More
- Paper at Acta Cryst D, Pillar data-acquisition strategies for cryo-electron tomography of beam-sensitive biological samples - Learn More
- Commentary at Acta Cryst C, 3D ED/MicroED entering a new era - Learn More
- Paper at Nature Communications, TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM - Learn More
- Article from Portland Press, CryoEM grid preparation: a closer look at advancements and impact of preparation mode and new approaches - Learn More
- Paper at Nature Methods, Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge - Learn More
- Paper at Nature Communications, Accurate Prediction of Protein Structural Flexibility by Deep Learning Integrating Intricate Atomic Structures and Cryo-EM Density Information - Learn More
- Paper at Acta Cryst C, TAAM refinement on high-resolution experimental and simulated 3D ED/MicroED data for organic molecules - Learn More
- From Science.org, Rebuilt U.S. x-ray source begins its bright new second life - Learn More
- The European Synchrotron offers a monthly webinar series exploring each of its beamlines and what it has to offer. Recorded versions of each webinar are available for viewing at a later date - Learn More
- Canadian Light Source is offering behind the scenes tour of its facility - Learn More
- Article at Argonne National Laboratory, Shine on: Upgraded Advanced Photon Source sees first X-ray light for science - Learn More
- Short radio interview concerning the work being done on a shutdown day at the Canadian Light Source - Learn More
- Find beamline proposal deadlines from around the world at Lightsources.org - Learn More
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20th Anniversary - Events | |
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As we celebrate 20 incredible years, we're taking a moment to appreciate the role that events have played in our journey. Whether it was a small workshop with a handful of passionate researchers or a major conference bustling with thousands, each event has left a lasting impression.
These experiences have not only allowed us to showcase our latest innovations in crystallography, cryo-EM, and beamline research, but they've also given us the invaluable opportunity to connect with you – our valued customers and partners. We cherish the conversations, the shared insights, and the friendships that have blossomed from these gatherings.
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Have your lab be the first to know. Follow us on social media! | | | | |
