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THE DUCT
A Monthly Newsletter for the PSC Community
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WE'RE EXCITED TO ANNOUNCE OUR
2022 PSC RESEARCH GRANTS!
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PSC PARTNERS ANNOUNCES
2022 RESEARCH GRANT AWARDEES
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The newly funded PSC Partners projects are:
Hepatic Unfolded Protein Response (UPR) in Murine Models of PSC - Lead Investigator: Young Investigator Alyssa Kriegermeier, MD, Northwestern University Feinberg School of Medicine
AWARD: $80,000 over two years (Young Investigator Award)
Novel Proteome-Wide Autoantibody Discovery in Primary Sclerosing Cholangitis - Lead Investigators: Young Investigator Michael Li, MD, PhD and Joseph DeRisi, PhD, University of California, San Francisco
AWARD: $80,000 over two years (Young Investigator Award)
Unraveling the Immune Triggers of Primary Sclerosing Cholangitis With and Without Concomitant Inflammatory Bowel Disease - Lead Investigator: Prof. Rinse K. Weersma, MD, PhD, University Medical Center Groningen, The Netherlands
AWARD: $60,000 over two years
The newly funded PSC Partners Canada project is:
Targeting PSC Pathogenesis Using a Bifunctional Peptide, GP119, in the Mdr2-/- Mouse Model of PSC and Novel Multicellular Human-Derived 3D PSC Organoids - Lead Investigators: Heather Francis, PhD, FAASLD and Gianfranco Alpini, PhD, Indiana University
AWARD: $60,000 over two years
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SIGN UP FOR SCIENCE NEWS! We will be providing detailed information about these grants and additional PSC-related scientific information in our new e-publication PSC Science News, which will be distributed later this month. To ensure you receive this publication, email us at contactus@pscpartners.org, and put Science News in the subject line. We will get you on the list!
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AN IN-DEPTH LOOK AT OUR
RESEARCH GRANT CYCLE
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PSC Partners and affiliate PSC Partners Canada offer two-year seed grants to conduct research that addresses an important and novel, basic, or clinical research question related to PSC and closely associated diseases (such as inflammatory bowel diseases [IBD] and cholangiocarcinoma). Each year, researchers from around the globe submit applications by our summer deadline.
Reviewing & Scoring Applications (confidential)
Determining Grant Recipients
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PSC Partners Research Committee meets to discuss SMAC scores and comments, and makes recommendations to the PSC Partners Board of Directors.
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The PSC Partners Board of Directors makes their final decision with a confidential vote.
- Updates are sent to all applicants, with award letters to the grant recipients.
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PSC Partners Canada makes funding decisions independent from PSC Partners.
Research Begins
- Funding for the first year of research is dispersed, and research projects begin.
- Grant recipients provide a Year 1 progress report for review by SMAC and a lay summary for the PSC Partners website.
- Second year funding is contingent upon a successful review of the progress report.
- Grant recipients complete the 2nd year of the research project and submit a final report.
Grants Cycle Ends
Final reports are submitted by researchers. PSC Partners staff conduct internal assessments on the impact, progress, and areas for growth of the grants program.
We are committed to PSC research funding!
PSC Partners selected four research seed grants in 2022, bringing our funding total to date to nearly $6 million dedicated to PSC research.
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BENEFITS OF DRUG REPURPOSING FOR RARE DISEASES:
A Conversation with Ania Korsunska
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"(Drug repurposing) is an opportunity to utilize existing drugs that are in development or already approved and redirect for the rare disease space," says Korsunska. "It's potentially cheaper than novel drug development, potentially faster. It's potentially easier to get these drugs into a position that a doctor can actually prescribe them."
PSC Partners Seeking a Cure is pleased to present Living With PSC, a podcast moderated by Independent Media Producer, Director, and PSC Patient Niall McKay. Each month, this podcast explores the latest research and knowledge about PSC. Topics include patient stories, latest research updates from PSC experts, collaborations that are necessary to find better treatments and a cure, and more. This podcast has it all!
Living with PSC can also be found wherever you download your podcasts.
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REGISTER FOR OUR UPCOMING WEBINAR |
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REGISTER FOR AN UPCOMING
PEER-TO-PEER SUPPORT ZOOMROOM
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PSC Partners ZoomRooms provide peer-to-peer support for our community. People who have attended in the past keep coming back, because they know these virtual gatherings are a great place to chat with others who truly understand.
ZoomRooms take place at 6 p.m. MT (5 p.m. PT, 7 p.m. CT, 8 p.m. ET.)
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HELP US PREPARE FOR THE
2023 PSC PARTNERS ANNUAL CONFERENCE
Plus, get a sneak peek into what we have planned so far, including date and location
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We are thrilled to be announcing information about the 2023 Annual Conference soon. Your participation in our March brainstorming session will help make this the best one yet! We’ll incorporate as many suggestions as possible as we continue to plan the details for the Annual Conference. We are interested in hearing from you and welcome all input. You can respond now in the registration questions when you click the button below, or during the webinar with the chat and polling features. Your ideas and questions are so valuable. |
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Welcome to Sandi's
Circle
Order a Copy of Sandi's Journey for Yourself or Someone You Care About!
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In this section of the newsletter, we share words of encouragement, advice, humor, memories, and more. All of these quotes come from the book Sandi's Journey, a collection of writings by Sandi Pearlman and memories from others about Sandi.
You can order a copy of the book yourself via Amazon. Plus, if you use AmazonSmile before the program is discontinued at the end of February, a percentage of your purchase is donated by Amazon to PSC Partners at no extra cost to you. CLICK HERE to sign up for AmazonSmile, and type Sandi's Journey into the Amazon search bar.
Folks who have been in the PSC Partners community remember Sandi Pearlman as a bright, positive light. Her insight, humor, and supportive presence were a real gift to those who knew her.
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SUPPORT PSC PARTNERS VIA
DONOR ADVISED FUND
A donor advised fund (DAF) is a type of giving program administered by a third party that provides you with the flexibility and most favorable tax benefits to easily support your favorite charities. DAFs are designed to manage charitable donations on behalf of an organization, family, or individual and are becoming increasingly popular. They are an excellent way to simplify your charitable giving and facilitate your strategic philanthropic goals. You will receive a tax deduction when you make a contribution of cash, stock, and other assets to your donor advised fund, and, at a later time, you can grant specified amounts to the charities of your choice. Click here to learn more about the benefits and how they work.
Donor Advised Fund Widget
For your convenience, we offer a widget on our website that links to three of the top Donor Advised Fund agents. If your Donor Advised Fund agent is not listed, contact them directly. Need help? Reach out to us at contactus@pscpartners.org or 303-771-5227.
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CHECK OUT THIS PSC-FOCUSED POEM CREATED VIA ARTIFICIAL INTELLIGENCE AND SHARED WITH US BY ANDY DENCH, A PERSON WITH PSC |
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Silent thief, creeping in,
Primary Sclerosing Cholangitis, a bitter friend.
Stealing health, stealing time,
A constant battle, a never-ending climb.
Inflammation, scarring, so severe,
Bile ducts narrowing, a future unclear.
Symptoms mounting, the body in strife,
A fight for survival, day by day, life.
Treatments offered, but not a cure,
Managing symptoms, to endure.
A burden on the liver, a burden on the soul,
PSC, a battle to be whole.
But hope remains, in research and care,
In the strength and determination, of those who dare.
To fight this disease, with all they've got,
With courage and grace, they will not be brought to a stop.
So let us honor, those who live with PSC,
A disease unseen, yet a battle fierce.
We stand in solidarity, in their fight,
For a cure, and a future, where they can see the light.
Andy, thank you for sharing!
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Our Mission: PSC Partners Seeking a Cure drives research to identify treatments and a cure for primary sclerosing cholangitis (PSC), while providing education and support for those impacted by this rare disease.
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6900 E. Belleview Ave., Ste 202,
Greenwood Village, CO 80111
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