TH: An essential marker for dopaminergic mid-brain organoids

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BIOSENSIS

TYROSINE HYDROXYLASE ANTIBODIES

Biosensis offers multiple TH antibodies from mouse

(M-1616-100 ), chicken

(C-2126-100) and rabbit

(R-1645-500 , R-118-100,

R-148-50, R-2120-100 ) that are suitable for IHC/ICC and western blot (WB) analyses.

R-148-50: Cryopreserved dissociated rat ventral mesencephalon neuronal cells, DIV 14 days stained with Biosensis R-148-100 (red) and beta III tubulin (green) antibodies (Photo courtesy of QBM Cell Science, Ottawa, Ontario, Canada).

C-2126-100: The section of the rat brain stained with chicken polyclonal antibody to tyrosine hydroxylase (green). Nuclear DNA is stained in blue.

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Is TH an essential marker for mid-brain organoids?

The image shows the expression of TH (red) along stained with Hoechst (blue) and MAP2 (green) in mice through IHC analysis using TH antibodies.

In the recent research article, Mohamed et al. (2022) successfully generated human mid-brain organoids (hMOs) to study the pathophysiology of PD and to develop the effective treatment methods.

They confirmed the identity of this organoid using TH immunochemistry for detecting dopaminergic neurons that are one of the specific cell populations found within hMOs.

TH: a gold standard marker

TH is recognized as a gold standard marker for identifying dopaminergic neurons and also adrenergic and noradrenergic neurons throughout the brain, which regulate various brain functions, including voluntary movement.

Biosensis' TH antibodies are used in immunohistochemistry to study the expression of TH for identifying normal and neurodegenerative disorders in the nervous system.

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The section of the rat brain stained with the mouse monoclonal antibody to tyrosine hydroxylase

(M-1616-100, red). Nuclear DNA is stained in blue.

(Photo courtesy of Dr. Erik Hrabovszky)

For easy online ordering, head to our new website, or contact our friendly sales team at sales@biosensis .com.

For more information about our products, email biospeak@biosensis.com.

Best wishes for your research,

The Biosensis Team

The image shows the expression of TH (red) along stained with Hoechst (blue) and MAP2 (green) in mice through IHC analysis using TH antibodies.

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