The RNA Transcript, March 14, 2022 |
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Six U-M Researchers to present at the 6th RNA Annual RNA Symposium, Towards our Future of RNA Therapeutics
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Graduate Student
Neurology
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Assistant Professor
Human Genetics
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Graduate Student
Bioinformatics
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Assistant Professor
Urology
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Graduate Student
Biological Chemistry
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Assistant Professor
Biological Chemistry
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RNA Center Manager, Martina Jerant, inducted into "Legends of the Ivy League" Hall of Fame |
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Prior to her world in RNA, Martina Jerant played basketball for Brown University and led her team to three Ivy League Titles and their first appearance in the NCAA Tournament. During her career, she was a three-time First Team All-Ivy selection, the Ivy League’s Rookie of the Year, as well as the Ivy League’s Player of the Year as only a sophomore. Jerant is the all-time leading rebounder in school history.
Martina continued on to play professional and Olympic Basketball before retiring her sneakers for the wonderful world of RNA! Read more>>
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U-M BioInnovations in Brain cancer Faculty Search Candidate Seminar |
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"Brain cancer, cellular communication, and RNA-guided immune systems"
Monday, March 14, 2022
11:00 am - 12:00 pm
Med Sci II West Lecture Hall - 3697 ( hybrid) |
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U-M Department of Molecular, Cellular, and Developmental Biology Connell Lecture |
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"On the molecular logic of synapse organization"
Stanford University
Monday, March 14, 2022
3:00 pm -4:30 pm
Rackham Amphitheatre
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U-M BRCF Advanced Genomics Core Seminar |
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RNA-Seq Demystified
UM Bioinformatics Core Winter 2022 Workshop Series
Thursday, March 14-16, 2022
9:00 am - 1:00 pm
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U-M Structure Seminar Series |
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"High throughput screening of small molecule binding partners for the FMN riboswitch by a multidisciplinary approach"
Thursday, March 18, 2022
11:00 am - 12:00 pm
LSI Library ( Hybrid, password: structure) |
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----Wednesday, March 23, 2022
----4:00 pm - 5:00 pm
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“The role of PIWI proteins and piRNAs in the eternal life of planarian stem cells”
"U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies"
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RNA Society Annual Meeting |
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Pfizer is seeking proposals for the advancement of RNA therapeutics and the development of the next generation of RNA medicines |
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Submissions invited for novel target concepts and therapeutic strategies amenable to RNA based approaches (mRNA, circular RNA, gene editing), in the following areas of interest:
- Cellular reprogramming:
- Cancer vaccines
- Infectious Disease Vaccines
- Chronic or Rare Kidney Disease (Focal Segmental Glomerulosclerosis, IgA Nephropathy, Alport Syndrome, or Autosomal Dominant Polycystic Kidney Disease)
- Rare Liver Diseases and Rare Neuromuscular Diseases
- Repeat Expansion Diseases (e.g. Huntington’s disease, Friedreich’s ataxia, ALS, myotonic dystrophy)
- Preference given to targets not amenable to small or large molecule intervention
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The Greene Laboratory at Columbia University in New York City is looking for highly motivated postdoctoral researchers interested in projects related to genome integrity and cancer biology. Applicants should have a Ph.D. in Biochemistry, Biophysics, or another relevant discipline. Experience with the biochemistry/biophysics of protein-nucleic acids interactions, CryoEM or single molecule imaging is beneficial. Click here for more details or email Prof. Eric C. Greene at: ecg2108@cumc.columbia.edu. |
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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RiPCA: An Assay for the Detection of RNA-Protein Interactions in Live Cells, Rosenblum, S. L., & Garner, A. L. (2022) Current Protocols, e358 (2). DOI: 10.1002/cpz1.358
Increasing interest in studying and modulating the interactions between RNAs and their RNA-binding proteins has indicated the need for enabling technologies. Existing means of detecting RNA-protein interactions (RPIs) are often limited to biochemical or post-lysis methods or cell-based methods that require the addition of an RNA-based affinity tag, such as the MS2 hairpin, precluding them from use in detecting small or highly processed RNAs. Taking advantage of bioorthogonal chemistry- and split-luciferase-based technologies, we developed an assay for the detection of RPIs in live cells. This article details the protocol and design considerations for RiPCA, or RNA interaction with Protein-mediated Complementation Assay.
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Molecular Determinants in tRNA D-arm Required for Inhibition of HIV-1 Gag Membrane Binding, Sumner, C., Kotani, O., Liu, S., Musier-Forsyth, K., Sato, H., & Ono, A. (2022). Molecular Determinants in tRNA D-arm Required for Inhibition of HIV-1 Gag Membrane Binding. Journal of molecular biology, 434(2), 167390. DOI: 10.1016/j.jmb.2021.167390
Keywords: acidic phospholipid; highly basic region; lipid-protein interaction; tRNA–protein interaction; virus assembly.
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