February 12, 2024

NRG Oncology Broadcast archives are accessible from our website at any time. Please bookmark this link for your convenience.

NRG2024 Virtual Sessions Start Today!

Are you attending any of the NRG2024 virtual sessions? Our zoom links to join our virtual sessions are now available! Read more here

Still Time to Register for the NRG Oncology Winter Meeting in Orlando!

The NRG Winter Meeting will be held in-person only at the World Center Marriott in Orlando, FL from Thursday, February 15, 2024 - Saturday, February 17, 2024 with select virtual session offerings. Please visit our meeting webpage for the agenda and more information. Register here

Winter Symposium - IDEA: Inclusion, Diversity, Equity and Access of Underrepresented Patients to Clinical Trials

Register here for the Winter 2024 Educational Symposium on Thursday, February 15, 2024 from 8am-12pm ET. The symposium will include noted Oncologists and Scientists serving as speakers and moderators. The speakers will focus their presentations on providing a framework for the barriers and solutions to increasing IDEA (Inclusion, Diversity, Equity, and Access) of underrepresented patients to clinical trials. Read more

NRG Oncology Particle Therapy Working Group Symposium

The NRG Oncology Particle Therapy Working Group Symposium is being held on Friday, February 16, 2024 from 10:15-10:50 am ET. The theme is “Overcoming Obstacles to Enrollment on Proton Therapy NRG Oncology Trials” and will be moderated by Charles B. Simone II, MD. The following talks are planned: Patient barriers: Engaging patients and enhancing their willingness to participate, presented by Kristin Higgins, MD; Provider barriers: Patient selection and enrollment equipoise, presented by Steven Lin, MD; and Enrollment challenges: Addressing insurance obstacles and designing pragmatic clinical trials, presented by Nancy Mendenhall, MD.

The Role of Spatial Biology in Oncology at #NRG2024

The NRG Translational Science Committee will be hosting their session “The Role of Spatial Biology in Oncology: Opportunities and Challenges for Translational Research” on Thursday, February 15, 2024 from 3-5pm at the upcoming NRG Meeting in Orlando. Presentations include the 3D spatial biology of archived FFPE tissue, new insights and opportunities in spatial biology, the multiplexed tissue imaging for biomarker and translational science discovery, and whole slide imaging mass cytometry for rapid profiling of tumor spatial heterogeneity and immune microenvironments. View the session flyer here. Register here. Click here to view the session flyer.

NRG Oncology Protocol Support Committee – Educational Sessions

Please be sure to sign up to attend the PSC Nurse/CRP Sessions being held during the NRG Oncology Winter Meeting in Orlando. The Protocol Support Committee (PSC) will offer Introduction to Clinical Trials: Principles of NRG Oncology Clinical Trial Management for Nurse/CRPs on Thursday, February 15; and Continuing Education Session for Nurse/CRPs on Friday, February 16. These sessions will be held virtually and in-person and are for both seasoned and new research staff. Please refer to the posted flyers and agendas (login required) for more details about the PSC programing offered at #NRG2024.

The PSC is thrilled to announce that the PSC sessions have been approved by the Virginia Nurses Association to award contact hours. The Virginia Nurses Association is accredited as an approver of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

#NRG2024 Social Media Workshop – Virtual Session Today!

The NRG Oncology Communications Committee is pleased to announce our Social Media Workshop as part of #NRG2024. The workshop, being held as a virtual session, is scheduled for today, Monday, February 12, from 4-5pm EST. Drs. Kristin Higgins and Miriam Knoll, members of the NRG Oncology Communications Committee, are the workshop chairs. The session speakers include Kristen Kimball, advocate for lung cancer awareness and retired physiology instructor from Boston; and Dr. Lucinda Morris, a radiation oncologist and co-chair of the Targeting Cancer initiative, from Sydney, Australia. Please see the session flyer for details. Register here for the session.

ACTIVATION

GYNECOLOGIC

EAY191-N5: Activation Date: February 12, 2024; version date: January 2, 2024 (posted on CTSU)

CLOSURE

GASTROINTESTINAL

NRG-GI005/COBRA: Notice of Permanent Closure to Accrual (posted on CTSU).

OTHER PROTOCOL NOTICES

1. ALL DISEASE SITES

NRG-GY022: Reminder: Actively Recruiting MALE Patients only Read More

2. BIOSPECIMEN BANK

Printing Biospecimen Transmittal PDFs from Rave

Please note an effort is underway to clarify how to obtain a Biospecimen Transmittal PDF for submission to the NRG Oncology Biospecimen Bank. Read More

3. CANCER CONTROL & PREVENTION

NRG-CC010: The study is now open to NRG sites in Japan and South Korea. The optional biospecimen collection does not apply to sites participating in these countries.

4. GENITOURINARY

NRG-GU008: Study overview video for participants is posted on NRG Oncology and CIRB approval is posted on CTSU. 

5. GYNECOLOGIC

EAY191-N4: Appendix XI, Section II, 1^st bullet: Reports should be REDACTED. Section 10.2: Footnote 2 will be deleted. These changes will be made with the next amendment.

GOG-0210: Reminder: Biospecimens, biomarker data, clinical data, and epidemiologic data are available for request. Please visit the NRG Oncology website for more information on this important study with the overall goal of improving the outcome and/or quality of life for patients with endometrial cancer.

NRG-GY031: Please note, there is an error in the section 4.2 table and the Biospecimen Collection and Submission Manual. The Part I PK collection is to be done on Cycle 1, Day 1, and Cycle 1, Day 8. This will be updated with the next amendment.

6. HEAD & NECK

NRG-HN008: Reminder: please update treatment and AE data weekly. This is a Phase I trial and timely data submission is very important.

7. VTOC TRAINING

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on NRG-HN001, NRG-HN002, NRG-CC003, NRG-CC005, NRG-BR009, NRG-CC011, and NRG/SWOG S1914. Space is limited so register now and reserve your seat. The next webinar training is scheduled for Wednesday, February 21, 2024. 

Press Release: NRG Oncology and the University of Pittsburgh demonstrate that a Machine Learning Model Predicts Oxaliplatin Benefit Using Data from Two NSABP Clinical Trials

The current standard of care for treating patients with stage 3 colon cancer is to use adjuvant therapy with FOLFOX, a combination of the drugs fluorouracil, leucovorin, and oxaliplatin. Although effective, the use of oxaliplatin can lead to known adverse events, mainly neurotoxicity that may be chronic. NRG Oncology tested a new machine learning model that can predict which colon cancer patients could derive benefit from the addition of oxaliplatin and could ultimately allow physicians to tailor treatment regimens better for their patients. The model used data from the NSABP C-07 and C-08 trials, both studies that utilized oxaliplatin in the treatment of colon cancer. Read more

NRG Oncology Confidential Member Survey

Please read our survey FAQ’s. All NRG Members should have received an email from the University of Chicago’s Survey Lab <noreply@qemailserver.com> containing a unique survey link. If you have not already completed the survey, please check your inbox and possibly your spam/junk mailbox for the email so that you can help us collect this important information. Please send any additional questions to nrg-broadcasts@nrgoncology.org.



Presidents Day

The NRG Oncology Philadelphia East Operations Center, Buffalo SDMC, and San Francisco Biospecimen Bank locations will be closed for the President's Day holiday on Monday, February 19, 2024. All other NRG Oncology offices and bank locations will be open during regular business hours.

NRG Oncology is pleased to report the scientific articles that have appeared during the previous week as well as an abstract accepted for presentation at the upcoming at the American Urological Association (AUA) Annual Meeting in May.

This publications report includes links, when available, to the article, PubMed abstract, or association abstract.

ACCEPTED ABSTRACTS

Morgan TM, Ren Y, Tang S, Zwerink W, Chen E, Mitani A, Huang H, Simko JP, DeVries S, Shipley WU, Pollack A, Bowes, D, Martin A, Balogh AG, Michalski JM, Greenberg MJ, Efstathiou JA, Bahary J, Ross AE, Esteva A, Showalter TN, Nguyen PL, Hoffman KE, Rodgers JP, Feng F, Spratt DE. Development and validation of a multimodal artificial intelligence (MMAI)-derived digital pathology-based biomarker predicting metastasis for radical prostatectomy patients with biochemical recurrence in NRG/RTOG trials. AUA (American Urological Association). Oral Presentation. 5/3/2024.

PUBLISHED ARTICLES

Chen L, Wang Y, Cai C, Ding Y, Kim RS, Lipchik C, Gavin PG, Yothers G, Allegra CJ, Petrelli NJ, Suga JM, Hopkins JO, Saito NG, Evans T, Jujjavarapu S, Wolmark N, Lucas PC, Paik S, Sun M, Pogue-Geile KL, Lu X. Machine Learning Predicts Oxaliplatin Benefit in Early Colon Cancer. J Clin Oncol. 2024 Feb 5:JCO2301080. doi: 10.1200/JCO.23.01080. Epub ahead of print. PMID: 38315963. Read More.

Dahl DM, Karrison TG, Michaelson MD, Pham HT, Wu CL, Swanson GP, Shipley WU, Vuky J, Lee RJ, Zietman AL, Souhami L, Chang BK, Deming RL, Ellerton JA, Sandler HM, Rodgers JP, Feng FY, Efstathiou JA. Long-term Outcomes of Chemoradiation for Muscle-invasive Bladder Cancer in Noncystectomy Candidates. Final Results of NRG Oncology RTOG 0524-A Phase 1/2 Trial of Paclitaxel + Trastuzumab with Daily Radiation or Paclitaxel Alone with Daily Irradiation. Eur Urol Oncol. 2024 Feb;7(1):83-90. doi: 10.1016/j.euo.2023.05.013. Epub 2023 Jul 11. PMID: 37442672; PMCID: PMC10782593. Read More.

Mak KS, Scannell Bryan M, Dignam JJ, Shipley WU, Lin Y, Peters CA, Gore EM, Rosenthal SA, Zeitzer KL, D'Souza DP, Horwitz EM, Pisansky TM, Maier JM, Chafe SM, Robin TP, Roach M 3rd, Tran PT, Souhami L, Michalski JM, Hartford AC, Feng FY, Sandler HM, Efstathiou JA. Cardiovascular Mortality and Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-term Update of NRG/RTOG 9202. Eur Urol Focus. 2024 Feb 1:S2405-4569(24)00011-7. doi: 10.1016/j.euf.2024.01.008. Epub ahead of print. PMID: 38307806. Read More.

Ross AE, Zhang J, Huang HC, Yamashita R, Keim-Malpass J, Simko JP, DeVries S, Morgan TM, Souhami L, Dobelbower MC, McGinnis LS, Jones CU, Dess RT, Zeitzer KL, Choi K, Hartford AC, Michalski JM, Raben A, Gomella LG, Sartor AO, Rosenthal SA, Sandler HM, Spratt DE, Pugh SL, Mohamad O, Esteva A, Chen E, Schaeffer EM, Tran PT, Feng FY. External Validation of a Digital Pathology-based Multimodal Artificial Intelligence Architecture in the NRG/RTOG 9902 Phase 3 Trial. Eur Urol Oncol. 2024 Jan 31:S2588-9311(24)00029-4. doi: 10.1016/j.euo.2024.01.004. Epub ahead of print. PMID: 38302323. Read More.

Please note the following upcoming meetings and abstract submission deadlines

UPCOMING MEETINGS

American Association for Cancer Research (AACR); Apr 5-10, 2024; San Diego, CA

American Association for Thoracic Surgery (AATS); Apr 27-30, 2024; Toronto, ON

American College of Radiology (ACR); Apr 13-17, 2024; Washington, DC

American Head and Neck Society (AHNS); May 15-16, 2024; Chicago, IL

American Radium Society (ARS); May 2-5, 2024; Palm Springs, CA

American Society of Breast Surgeons (ABS); Apr 10-14, 2024; Orlando, FL

American Society of Clinical Oncology (ASCO); May 31-Jun 4, 2024; Chicago, IL

European Society of Gynaecological Oncology (ESGO); Mar 7-10, 2024; Barcelona, Spain

European Society for Radiotherapy and Oncology (ESTRO); May 3-7, 2024; Glasgow, Scotland

Society for Clinical Trials (SCT); May 19-22, 2024; Boston, MA

Society of Gynecologic Oncology (SGO); Mar 16-18, 2024; San Diego, CA

Society of Surgical Oncology (SSO); Mar 20-23, 2024; Atlanta, GA

Society of Surgical Oncology (SSO) - Advanced Cancer Therapies (ACT); Feb 16-19, 2024; San Juan, Puerto Rico



UPCOMING ABSTRACT SUBMISSIONS DEADLINES

American Brachytherapy Society (ABS) World Congress; Jul 10-13, 2024; National Harbor, MD; due to publications committee Feb 13, 2024; submission deadline Feb 27, 2024, 6:00 pm PT

American Society of Colon and Rectal Surgeons (ASCRS); Jun 1-4, 2024; Baltimore, MD; submission deadline Feb 13, 2024, 11:59 pm PT

American Society for Radiation Oncology (ASTRO); Sep 29-Oct 2, 2024; Washington, DC; due to publications committee Feb 27, 2024; submission deadline Mar 12, 2024; LBA Jul 12, 2024

EORTC-NCI-AACR Symposium on Molecular Targets and therapies; Oct 23-25, 2024; Barcelona, Spain; due to publications committee Jun 13, 2024; submission deadline Jun 27, 2024; LBA Sep 26, 2024

European Society for Medical Oncology (ESMO); Sep 13-17, 2024; Barcelona, Spain; due to publications committee Apr 23, 2024; submission deadline May 7, 2024, 21:00 CET; LBA Aug 7, 2024, 21:00 CET (placeholder required)

European Society for Medical Oncology (ESMO) Breast Cancer; May 15-17, 2024; Berlin, Germany; submission deadline Feb 13, 2024, 21:00 CET; LBA Apr 17, 2024, 21:00 CET (placeholder required)

European Society for Medical Oncology (ESMO) Gastrointestinal; Jun 26-29, 2024; Munich, Germany; submission deadline Apr 9, 2024, 21:00 CET; LBA Jun 6, 2024, 21:00 CET (placeholder required)

European Society for Medical Oncology (ESMO) Gynaecological; Jun 20-22, 2024; Florence, Italy; due to publications committee Mar 20, 2024; submission deadline Apr 3, 2024, 21:00 CET (placeholder required)

International Society for Quality-of-Life Research (ISOQOL); Oct 13-16; Cologne, Germany; due to publications committee Mar 25, 2024; submission deadline Apr 8, 2024, CET