Keynote Speaker - Victoria D'Souza, Ph.D. | | |
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8th Annual Symposium Speaker
"Structure-based redefinition of HIV-1 Reverse Transcription Initiation"
Victoria D'Souza, Ph.D.+
Professor of Molecular and Cellular Biology
Harvard University
Abstract: In retroviruses, reverse transcription is initiated from an intermolecular duplex primer formed by nucleocapsid-driven annealing of the U5-primer binding site (U5-PBS) region of the genome with a host tRNA. I will present data that redefines our basic understanding of this complex by assigning RT an additional structural remodeler role, separate from its enzymatic function, and then discuss a unique mechanism that contributes to the control of start of DNA synthesis in virions. I will also highlight the potential importance of organization of the initiation complex in a dimeric genome context, and the role of nucleocapsid during initiation and extension.
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RNA Innovation Seminar Series | |
Upcoming Affiliated Seminars | | |
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HMS Initiative for RNA Medicine Seminar Series
"Small and Large Machine Learning Models to Decipher the Translational Control of Gene Expression"
Mihaela Zavolan, M.D., Ph.D.,
Professor in Computational Biology/Genomics
Biozentrum, University of Basel
Switzerland
Tuesday, February 6, 2024 | 3:00 – 4:00 PM EST
To Join Virtually Click This Link
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Penn Institute for RNA Innovation Seminar Series
"RNA binding protein-RNA landscapes in health and disease"
Eugene Yeo, Ph.D.
University of California San Diego (UCSD)
Professor of Cellular and Molecular Medicine
Director for UCSD's Center for RNA Technologies and Therapeutics
Tuesday, February 6, 2024, 4 PM ET Zoom Registration
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For more information and to view the full schedule of upcoming U-M Oral Defenses, please visit the Rackham Graduate School Oral Defenses website. | |
From our sponsor: Lexogen RNA Expertise Blog Series | |
Yan Zhang's Lab Article in Molecular Cell | |
John Prensner Publishes Findings on New Treatment for Medulloblastoma | |
Scientist Will Test a Cancer-Hunting mRNA Treatment | | |
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Stran Therapeutics has figured out a way to turn the molecule on and off in certain tissues to more precisely treat tumors.
Read the full story in WIRED by Emily Mullin, January 22, 2024.
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Nils Walter & Adrien Chauvier publish new review article - and it's about time... literally! | | |
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Center for RNA Biomedicine Co-Director Nils Walter, Ph.D. is excited about sharing some news about yet another fascinating role RNA plays in gene regulation – and it’s about time… literally.
In a new review article, “Regulation of bacterial gene expression by non-coding RNA: It is all about time!” published January 10, 2024, in the journal Cell Chemical Biology, Walter and his colleague Adrien Chauvier, Ph.D., at the Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, discuss the vital role that speed plays in the process of non-coding RNA (ncRNA) folding in bacteria.
Read the full review article: Science Direct
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Dr. Rao's Michigan Answer: Finding New Hope for People with Vision Loss | | |
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"Unmasking the Power of RNA: From Structure to Medicine"
The 8th annual symposium will take place on Friday, March 8, 8:30 a.m. - 5:00 p.m. in the A. Alfred Taubman Biomedical Science Research Bldg., Kahn Auditorium at 109 Zina Pitcher Place in Ann Arbor, Michigan. Speakers include:
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Drew Weissman, M.D., Ph.D., University of Pennsylvania, 2023 Nobel laureate for Physiology or Medicine for his work on mRNA vaccines
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Victoria D'Souza, Ph.D., Harvard University
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Brenton R. Graveley, Ph.D., University of Connecticut
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Leemor Joshua-Tor, Ph.D., Cold Spring Harbor Laboratory
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Peter Todd, M.D., Ph.D., University of Michigan
Full Symposium Program Now Available
REGISTER TODAY
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HIRM 2024 Symposium, April 25, 2024 - Registration Open! | | |
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2024 Symposium
HIRM 10 Year Anniversary Symposium
Thursday, April 25, 2024
Joseph B. Martin Conference Center
77 Avenue Louis Pasteur
Boston, MA 02115
Registration & Poster Session is Open
Submit a Poster Email: glee8@bidmc.harvard.edu
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RNA Society Annual Meeting May 28 - June 2, 2024 | |
Exciting News! RiboClub 25th / RiboWest 20th / TREnD 8th Anniversary Celebration in Ottawa: RNA Canada 2024: The future of RNA technology | | |
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Our members' publications are available through Altmetric. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights. Bold denotes CRB member.
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Chauvier A, Walter NG. Regulation of bacterial gene expression by non-coding RNA: It is all about time! Cell Chem Biol. 2024 Jan 18;31(1):71-85. doi: 10.1016/j.chembiol.2023.12.011. Epub 2024 Jan 10. PMID: 38211587.https://doi.org/10.1016/j.chembiol.2023.12.011 | |
Wilhelm CA, Mallik L, Kelly AL, Brotzman S, Mendoza J, Anders AG, Leskaj S, Castillo C, Ruotolo BT, Cianfrocco MA, Koutmos M. Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. J Biol Chem. 2023 Oct 6:105327. doi: 10.1016/j.jbc.2023.105327. Epub ahead of print. PMID: 37806495. https://doi.org/10.1016/j.jbc.2023.105327 | |
Kharytonchyk S, Burnett C, Gc K, Telesnitsky A. Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements. J Virol. 2023 Sep 28;97(9):e0081823. doi: 10.1128/jvi.00818-23. Epub 2023 Sep 8. PMID: 37681957; PMCID: PMC10537674. https://doi.org/10.1093/nar/gkad866 | |
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The Department of Molecular Genetics in the College of Arts and Sciences at The Ohio State University invites applications for the position of Ohio Eminent Scholar in Molecular Genetics, an endowed, tenure-track position at the Associate or Full Professor level. The Ohio Eminent Scholars (OES) Program, created by the Ohio General Assembly and administered by the Ohio Board of Regents, aims to enhance the national eminence of selected outstanding academic programs at Ohio universities by attracting internationally recognized scholars. Applications are sought from those with a distinguished track record of investigating fundamental biological questions in any system.
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University of Michigan BIBC Tenure Track Faculty Search
The University of Michigan has launched a Tenure Track Faculty Search for the BioInnovations in Brain Cancer Initiative (BIBC), led by Center for RNA Biomedicine Faculty Member Dr. Maria G. Castro and Dr. Steven Schwendeman. Learn more.
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The University of California Irvine (UCI), Department of Ophthalmology
Full-Time Position
Inviting applicants focused on the development of genetic engineering and genome editing technologies. Learn more.
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Postdoctoral Research Fellow and Graduate Research Assistants
Dr. Guizhi (Julian) Zhu Lab | University of Michigan
Multiple full-time openings for Postdoctoral Research Fellow and Graduate Research Assistants. Learn more.
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Research Technician and Post-Doctoral Research Fellow | Fred Hutchinson Cancer Center | The Lapointe Lab
Seeking to fill two positions: Research Technician and Post-Doctoral Research Fellow. Learn more.
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Research Technician - Yadavalli Lab
Seeking full-time technician or research scientist to perform cutting-edge research in RNA biology using high-throughput sequencing methods. Learn more.
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Postdoctoral Position - Maquat Lab
A postdoctoral position is open. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology. Learn more.
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Postdoctoral Position - Cooperman Laboratory
Seeking postdoctoral student with a strong interest in understanding the mechanism and regulation of cytoplasmic eukaryotic protein synthesis. Learn more.
| | For complete details on current openings and how to apply for these positions, visit the Recruitment Opportunities page on our website | | | | |
