The RNA Transcript, February 21, 2022 |
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Dr. Rao works at both sides of the research spectrum. On one end, he studies the basic RNA transcription mechanisms in pluripotent stem cells that become either retinal cells, or specialized cells such as cones and receptors. On the other end, as a clinician, he collaborates with the Neural Stem Cell Institute, in Rensselaer, NY, in a clinical trial for advanced macular degeneration. The team creates and implants differentiated stem cells that become retina cells in these patients. Read more >>
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RNA Symposium "Data Blitz" Abstracts (Due 3/1) |
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University of Michigan RNA students, postdocs, and junior faculty are invited to submit an abstract for our Annual Symposium. Six applicants will be selected to present their research in a "Data Blitz" (8-min talk with 2-min Q&A).
Abstract deadline: Monday, March 1st, 2022
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Pfizer is seeking proposals for the advancement of RNA therapeutics and the development of the next generation of RNA medicines
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Submissions invited for novel target concepts and therapeutic strategies amenable to RNA based approaches (mRNA, circular RNA, gene editing), in the following areas of interest:
- Cellular reprogramming:
- Cancer vaccines
- Infectious Disease Vaccines
- Chronic or Rare Kidney Disease (Focal Segmental Glomerulosclerosis, IgA Nephropathy, Alport Syndrome, or Autosomal Dominant Polycystic Kidney Disease)
- Rare Liver Diseases and Rare Neuromuscular Diseases
- Repeat Expansion Diseases (e.g. Huntington’s disease, Friedreich’s ataxia, ALS, myotonic dystrophy)
- Preference given to targets not amenable to small or large molecule intervention
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U-M Life Sciences Institute Research Seminar |
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"Tackling disease-associated biomolecules: from RNA therapeutics to single-molecule detection"
Monday, February 21, 2022
9:00 am - 10:00 am
Forum Hall, Palmer Commons
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U-M Department of Chemistry Seminar |
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"Activity-based chemical probes for RNA modifying enzymes"
Tuesday, February 21, 2022
4:00 pm - 5:15pm
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----Wednesday, February 23, 2022
----4:00 pm - 5:00 pm
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"Hyperactive translation programs during cardiac remodeling"
"Unexpected interactions with the integrator complex"
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NIH National Center for CryoEM Access and Training: CryoEM Current Practices Webinar
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"Mechanisms driving molecular innovation: Cryo-EM studies of CRISPR-associated transposons"
Thursday, February 24, 2022
12:00 pm - 1:00 pm
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"Machine learning in cryo-EM"
Friday, February 25, 2022
10:00 am - 11:00 am
Life Sciences Institute - LSI Library
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U-M Department of Molecular, Cellular and Developmental Biology Seminar |
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"Chromatin, transcription regulation in ethylene response and drought stress"
Friday, February 25, 2022
12:00 pm - 1:00 pm
Biological Sciences Building - 1060
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U-M BioInnovations in Brain Cancer Faculty Candidate Seminar |
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"Small circular mRNA (circRNA) vaccines for cancer immunotherapy and beyond"
Friday, February 25, 2022
12:00 pm - 1:00 pm
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U-M Center for RNA Biomedicine Seminar |
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"Translating the cancer genome: dark matter proteins"
Boston Children’s Cancer and Blood Disorders Center
Harvard Medical School
Monday, February 28, 2022
4:00 pm - 5:00 pm
BSRB, ABC Seminar rooms ( hybrid) |
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Co-Hosts: Department of Computational Medicine & Bioinformatics, and Department of Pediatric Oncology |
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Chemistry-Biology Interface (CBI) Program Symposium |
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Keynote speakers:
Abstract Submission Due: Friday, February 25th
March 24-25, 2022
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures, Khun Zaw Latt, Jurgen Heymann, Joseph H. Jessee, Avi Z. Rosenberg, Celine C. Berthier, Arnon Arazi, Sean Eddy, Teruhiko Yoshida, Yongmei Zhao, Vicky Chen, George W. Nelson, Margaret Cam, Parimal Kumar, Monika Mehta, Michael C. Kelly, Matthias Kretzler, Kidney International Reports (2022) 7, 289–304, DOI: 10.1016/j.ekir.2021.11.005
The identification of monocyte subsets and podocyte expression signatures in the urine samples of subjects with FSGS suggests that urine cell profiling might serve as a diagnostic and prognostic tool in nephrotic syndrome. Furthermore, this approach may aid in the development of novel biomarkers and identifying personalized therapies targeting particular molecular pathways in immune cells and podocytes.
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