Boosting Resolution: Electric Fields in Protein Crystallography | | Image source - Figure 1 (Adapted) from Khakurel et al. (2025). European Biophysics Journal. https://doi.org/10.1007/s00249-025-01731-5. Published under a Creative Commons Attribution 4.0 International License. | | In a paper in the European Biophysics Journal, Khakurel et al. (2025) explore a novel approach to enhance resolution in X-ray protein crystallography. Their method involves applying a high-voltage electric field to protein crystals after crystallization. The study demonstrates that this application of an electric field can improve crystal diffraction quality and thus enhance resolution. The authors also show that the protein structure remains largely unperturbed up to a certain electric field threshold. This "on-the-fly" resolution enhancement offers a promising avenue for improving the analysis of protein crystals. | | Supporting Crystallography Innovation | | | | The study by Khakurel et al. (2025) exemplifies the ongoing pursuit of enhanced techniques in X-ray crystallography. This research aligns with MiTeGen's mission to empower scientists with cutting-edge tools and technologies. We are dedicated to providing the research community with the resources necessary to push the boundaries of structural biology. Our broad portfolio of crystallography tools is designed to support both established methodologies and the development of novel approaches, ultimately accelerating scientific discovery. | | Instruct-ERIC Funded Access to Structural Biology Technologies | | | | Instruct-ERIC is providing funding to both academic and commercial scientists within their member countries and organizations, granting access to vital structural biology technologies. This funding encompasses advanced equipment like NMR, cryo-EM, and X-ray, as well as essential sample preparation and biophysical techniques. Applications are accepted continuously, offering flexibility for researchers. The next submission deadline is April 24th. Don't miss this opportunity to advance your research with state-of-the-art resources. Explore the possibilities and submit your proposal today. | | New Product - FIB Autogrid Rings and C-clips | | | | Nanosofts FIB Autogrid Rings and C-Clips are designed to streamline your focused ion beam (FIB) sample preparation for cryo-EM. These precision-engineered components ensure secure and stable mounting of autogrids, enhancing the efficiency and reliability of your workflow. With easy handling and robust construction, these rings and clips are essential for researchers seeking high-quality cryo-EM data. Discover how our FIB Autogrid Rings and C-Clips can optimize your sample preparation process. Click below to learn more. | | ACA Survey - Availability of Structural Science Infrastructure in the US | | | | The US National Committee for Crystallography of the American Crystallographic Association and the RCSB PDB are conducting a vital survey to assess the current state of structural science infrastructure across the United States. This initiative aims to pinpoint strengths and weaknesses in available resources, directly informing future workshops and seminars. Your input will help stakeholder organizations prioritize improvements and ensure the community has access to the tools and support needed for cutting-edge research. Click below to participate in the survey. | | New Product - X-Ray Silicon Nitride Windows | | | | |
SiMPore’s X-ray Silicon Nitride Windows offer exceptional transmission and minimal background scattering, which is ideal for sensitive X-ray experiments. These single-window designs provide robust and ultra-thin support for samples, enhancing data quality and resolution.
Perfect for researchers demanding precision, these windows ensure reliable performance in diverse applications. Click the button below to discover how these Silicon Nitride Windows can elevate your X-ray analysis.
| | Learn How Your Purchases Help Support Scientific Events | | Did you know that a percentage of each purchase you make with us directly supports scientific events? At MiTeGen, we're committed to fostering the growth of structural biology and related fields. That's why we dedicate a portion of our resources to sponsoring a variety of scientific gatherings throughout the year. Your purchases enable us to provide vital financial and in-kind assistance, ensuring these events thrive and connect researchers. By choosing MiTeGen, you're not just acquiring high-quality products; you're actively investing in the advancement of scientific discovery. We're proud to partner with you in facilitating knowledge sharing and propelling the future of science. | | FEBS Workshop 2025: Time-resolved spectroscopy meets time-resolved crystallography is May 6-8 in Pecs, Hungary. Lectures and research presentations will address topics such as time-resolved spectroscopy, serial and time-resolved crystallography at synchrotrons and XFELs, software development and more. We are sponsoring this workshop. | | The 12th International Workshop on X-ray Radiation Damage to Biological Samples is June 3-5 in Villigen, Switzerland. The workshop will address the essential questions and challenges of radiation damage to biological samples during their examination with ionizing radiation. In addition, it will cover various X-ray and electron scattering techniques. We are sponsoring this workshop. | | Events, Workshops and Conferences | | | | |
If you are looking for more events, please visit our events page. It lists conferences, workshops, symposiums, user meetings, and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research, and more.
| | Industry Resources and News | | |
Here is a small selection of industry resources and news for your browsing.
-
Paper at Acta Cryst F, The first report of structural analysis of a nucleic acid using crystals grown in space - Learn More
-
Paper at Acta Cryst D, Useful experimental aspects of small-wedge synchrotron crystallography for accurate structure analysis of protein molecules - Learn More
-
Paper at Acta Cryst D, Has AlphaFold3 achieved success for RNA? - Learn More
-
The ICDD has announced the winners of the Ludo Frevel Crystallography Scholarship, Learn More
-
From the CCDC blog, How Your Structure Is Curated in the CSD – The Journey of a CSD Entry - Learn More
-
From the CCDC blog, The CCDC and Durham University Awarded Innovate UK Grant to Advance Sustainable Medicines Manufacturing through Digital Particle Engineering - Learn More
-
Article at IUCrJ, Small but mighty: the power of microcrystals in structural biology - Learn More
-
Preprint at bioRxiv, SLICK: A Sandwich-LIke Culturing Kit for in situ Cryo-ET Sample Preparation - Learn More
-
Article at Research Institute of Molecular Pathology (IMP), FakET: new method advances electron microscopy with AI simulations - Learn More
-
Article in Nature, Structure of a human AMPA receptor with TARP auxiliary subunit - Learn More
-
Paper at Acta Cryst D, Slice'N'Dice: maximizing the value of predicted models for structural biologists - Learn More
-
Preprint at bioRxiv, The graphene-based affinity cryo-EM grid for the endogenous protein structure determination - Learn More
-
Preprint at bioRxiv, Foam film vitrification for cryo-EM - Learn More
-
Article at ANSTO website, Photographer captures images inside the main ring of the Australian Synchrotron - Learn More
-
Paper at Synchrotron JSR, Present and future structural biology activities at DESY and the European XFEL - Learn More
-
Paper at Synchrotron JSR, Macromolecular crystallography at SPring-8 and SACLA - Learn More
-
Canadian Light Source and CISR are collaborating to develop a plan to serve the future needs of the Canadian synchrotron radiation community, and they want your input - Learn More
-
Find beamline proposal deadlines from around the world at Lightsources.org - Learn More
| | Experience the MiTeGen Difference: Dedicated Support Every Step of the Way | | At MiTeGen, we prioritize your research and value your time. We're committed to providing proactive and responsive customer service, ensuring you have the support you need, when you need it. From pre-order inquiries to post-shipment follow-ups, our team is dedicated to addressing your questions and concerns promptly. We believe in anticipating your needs and resolving issues before they arise, allowing you to focus on your research. Have a question about our products, services, or your order? Contact us today; we're here to assist you. | | Have your lab be the first to know. Follow us on social media! | | | | |
