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Dear Researcher,
Neurofilaments are type IV intermediate filament proteins found in the cytoplasm of neurons, and they are primarily composed of three essential proteins: NF-L (Light), NF-M (Medium), and NF-H (Heavy). They are thought to be mainly responsible for providing structural support for axons and regulating axon diameter, which influences nerve conduction velocity.
Recently, the detection of neurofilament protein in the blood and CSF, in particular NF-L protein, has sparked much interest in NF-L as a biomarker to identify CNS injury and degeneration. Antibodies to neurofilament proteins are used primarily to identify neuronal cells and their processes in cell culture and in sectioned material. Biosensis' antibodies can be useful for visualizing the neurofilaments in many neurological diseases, such as Lou Gehrig's disease, giant axon neuropathy, Charcot-Marie Tooth disease, and many others.
Biosensis offers a range of validated neurofilament antibodies from Chicken, Mouse and Rabbit hosts.
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