SHARE:  
Ready Set Research 2021 Email Header_2.png

November 23, 2022

Dear Colleagues,

 

Dear Colleagues,

Welcome to the November 2022 edition of the department's research update. There are several new grant awards to announce this month, which is great news, and congratulations to all these recipients. You'll see again how we manage to cover the whole range of basic science to translational to clinical research projects.

 

Obtaining research funding from outside agencies is an important transition point. It marks the beginning of a new period of productivity for the investigator, but it comes after usually years of preparatory work and smaller experiments. Often it can be difficult to spot opportunities for research among the pressures of clinical and teaching responsibilities, but we always want to be encouraging residents and junior faculty to explore their research ideas. It's an important part of working in an academic environment, and a way of investing in our future. To that end, we'll be having some evening sessions over the coming weeks to help residents and junior faculty get oriented and engaged in research projects. If you haven't already heard about these meetings and would like to be involved, please do drop me a line.


Chris Connor

Awards & Grants

Recently Funded Awards

Awardee: Dr. Robert Edwards


Project title: CTA: Prospective Study to Evaluate a Digital Regimen for Fibromyalgia Management – POSPER-FM

Funding Agency/Sponsor: Swing Therapeutics, Inc.


Project title: PRROPS: Pathways of Risk and Resilience for Overlapping Pain and Sensitization

Funding Agency/Sponsor: Trustees of Boston University/NIH

Awardee: Dr. Sungwhan Oh

Project title: Supplement: Contribution of phytochemicals to gut symbiont colonization and synthesis of immunomodulatory sphingolipids

Funding Agency/Sponsor: NIH-NCCIH

Awardee: Dr. Robert J. Yong

Project title: CTA: A Phase 3, multicenter, randomized, double-blinded, placebo-controlled study, to evaluate the safety and efficacy of SB-01 for injection for the treatment of lumbar degenerative disc disease

Funding Agency/Sponsor: Spine BioPharma, LLC

Awardee: Dr. Vesela Kovacheva


Project title: IGNITE AWARD: Novel, Closed-loop Drug Infusion Automation System Utilizing Machine Learning: Proof of Concept Algorithm to Maintain Stable Hemodynamics in Patients Presenting for Cesarean Delivery

Funding Agency/Sponsor: Brigham and Women’s Hospital – Internal Funds


Project title: Personalized postpartum hemorrhage Prediction using Machine Learning and Polygenic Risk Scores

Funding Agency/Sponsor: NIH

Awardee: Dr. Jingjing Gao

Project title: RNAi Gene Therapy Targeting Microlial CD33 for Alzheimer’s Disease

Funding Agency/Sponsor: Alzheimer’s Association

Awardee: Dr. Matthew Spite

Project title: Critical Mediators of Inflammation Resolution and Immune Memory in Atherosclerosis

Funding Agency/Sponsor: Vanderbilt University/NIH

Awardee: Dr. Robert Jamison

Project title: CTA: Efficacy of the Quell Wearable Device for Treatment of Central Sensitization-related Pain Among Persons with Chronic Overlapping Pain Conditions

Funding Agency/Sponsor: NeuroMetrix, Inc.

More than 70 researchers from across the Mass General Brigham healthcare system have been named to the annual Highly Cited Researchers™ 2022 list from Clarivate. Congratulations to Investigators from our Department!

Omid Farokhzad, MA, MD, MBA

Charles Serhan, PhD

Jinjun Shi, PhD

Wei Tao, PhD

Announcements

On the13th of September 2022, Dr. Serhan was honored at the "Synthèse de Lipides Bioactifs" laboratory in Montpellier in a workshop to celebrate enzymatic and non-enzymatic metabolites of PUFAs.

Chris Connor is the Principal Investigator on the new five-year NIH grant R35 GM145319, "Pan-neuronal functional imaging and anesthesia". This continues his work on imaging the basic mechanism of action of anesthetics in genetically-modified C.elegans (as published in Anesthesiology) and on reverse-engineering the hallmarks of anesthesia in the human EEG (as published in Anesthesia & Analgesia). They aim to bring about a convergence of these two approaches to explain the effects of volatile anesthetics on human unconsciousness.

 

The paper describing, finally, the internal workings of the BIS algorithms was published in the October print issue of A&A, Open Reimplementation of the BIS Algorithms for Depth of Anesthesia, Anesth Analg 2022;135(4):855-864.

 

BWH Anesthesia Research Retreat

Missed the BWH Anesthesiology Annual Research retreat?! You can find the video of Chad Brummett's Keynote lecture, all the rapid-fire presentations, as well as Dr. Rathmell's pictures of the retreat in Microsoft Teams, BWH Anesthesia Department under the Research tab in files: Research Retreat 2022.


This year's poster award winners (pictured above) were: Mikayla Flowers (Dr. Schreiber accepting on her behalf), Swetharajan Gunasekar, Ryan Yip, and Agustina Mena.

Featured Investigator Interview

Kathy Chen, MD

Dr. Chen is an attending anesthesiologist, who specializes in regional anesthesia here at Brigham and Women’s Hospital in the Department of Anesthesiology, Perioperative and Pain Medicine. She grew up in Maryland and Texas, received a B.S. in Biochemistry at the University of Maryland at College Park, and worked for two years at the NIH before attending the University of Vermont for Medical school after much encouragement from her research mentors. Dr. Chen returned to Maryland for her internship to be closer to family before joining BWH for her anesthesiology residency and fellowship in regional anesthesia. She was awarded ‘Distinguished Resident’ (2020) and ‘Fellow of the Year’ (2021), respectively, and she joined the BWH Anesthesia Clinical Faculty in 2021. Dr. Chen’s long-term career goal is to become an independent physician-scientist and leader in the field of academic anesthesiology with a focus on how to personalize and optimize a patient’s experience with regional anesthesia.

Dr. Chen first became interested in science and research in high school. She was accepted to a Summer Intramural Research Training Award (IRTA) at the National Institutes of Health (NIH) in 2005 under the direction of Dr. Joshua Farber, MD, studying the role of CXCL16 and prostate cancer. Dr. Chen found research incredibly enjoyable and continued to pursue her research interests in college in a bioorganic research lab studying electron transfer in DNA. She was awarded a Howard Hughes Medical Institute (HHMI) Undergraduate Research Fellowship between 2008-2010. Post-college, Dr. Chen was deciding between medicine and research and was accepted to the NIH Post-baccalaureate IRTA program to work with Dr. Amy Klion, MD in a translational research laboratory, studying hypereosinophilia. She ultimately decided to pursue a medical degree with the hopes of becoming a physician-scientist. After deciding to pursue a career in Anesthesiology, Dr. Chen has combined her concerns for opioid use disorders, her interest in medical education for patients and trainees, and the advances in regional anesthesia in hopes of providing safe multimodal anesthesia and analgesia, to patients undergoing surgical procedures.

During residency, she was mentored by Dr. Vesela Kovacheva, where she helped extract hemodynamic data on patients undergoing cesarean section with spinal anesthesia. She also reviewed how anxiety and anesthesia may be related, publishing a scoping review titled “Less Stress, Better Success: A Scoping Review on the Effects of Anxiety on Anesthetic and Analgesic Consumption.” She was also mentored by Dr. Alex Arriaga to pursue her interest in medical education through a mixed-methods research project looking at data-driven didactics and how providing data with residents could be helpful. This work was published in the Journal of Clinical Anesthesia titled “Education based on publicly-available keyword data is associated with decreased stress and improved trajectory of in-training exam performance.” Under the mentorship of Dr. Kristin Schreiber, she has published a narrative review in Anaesthesia titled “The role of regional anaesthesia and multimodal analgesia in the prevention of chronic post-surgical pain.” Her research and interest in regional anesthesia ultimately led her to pursue a fellowship in Regional Anesthesia and Acute Pain.

Dr. Chen loves what she does and states, “if there is a way to help relieve a person’s perioperative pain especially with a regional anesthetic technique, I want to.” During her fellowship, she conducted a randomized trial in healthy volunteers to assess how different combinations and doses of local anesthetics could affect pressure pain in a human model of compartment syndrome. She recently published her original research in Regional Anesthesia and Pain Medicine titled “Impact of Varying Degrees of Peripheral Nerve Blockade on Experimental Pressure and Ischemic Pain: Adductor Canal and Sciatic Nerve Blocks in a Human Model of Compartment Syndrome Pain.”

Stemming from the qualitative data looking at how healthy volunteers from the compartment syndrome study experience nerve blocks, Dr. Chen’s current project is looking at whether or not patients with high or low pain catastrophizing may benefit from titrated sedation versus intraprocedural reassurance and education when receiving a nerve block. Can we help improve the experience by looking at how people experience procedural pain? She hopes this will provide clinical changes to how we deliver regional anesthesia to our patients as we continue to personalize medicine for individuals receiving surgery. Dr. Chen is passionate and cares a great deal about leading projects to help address these issues in addition to teaching others. When Dr. Chen does get a chance to take some time off, she loves spending time with her family and friends as well as travelling and trying all kinds of food. 

Finding Funding

8deb3453-36e6-4195-be1f-16d0dbe95579 image

Are you considering submitting a grant?

Please reach out to Rachel Abrams for a list of required documents and to get the process started.

Featured Opportunities

BRIGHAM-BASED


BRI Centers, Programs, Initiative Awards

Amount: $1,000 - $10,000

Deadline: rolling basis

Eligibility details here


BRI Microgrants

Amount: $500 - $1,000

Deadline: Applications accepted on a rolling basis

Apply Here


MGB Collaborative Grant Application

Details: https://covidinnovation.partners.org/funding/


COVID-19 Funding opportunities

https://covidinnovation.partners.org/funding/


Brigham–Wyss Diagnostics Accelerator (DxA)

The Brigham–Wyss Diagnostics Accelerator aims to create new diagnostic technologies through deep collaborations driven by unmet diagnostic needs.

More details here.



DEPARTMENTAL


Anesthesiology Department Seed Funding

Deadline: Rolling

Funding: up to $10,000 

Eligibility: Lecturer, Instructor, Assistant, or Associate Professor at the time of award funding

  • Goal: Support clinical, translational, or basic science research and project development
  • Prerequisites: 
  • Grantee should have a mentoring plan (senior mentor or mentoring team in area of proposed investigation)
  • Grantee should have a career development plan

Up to five seed grants will be awarded in 2022. Grant recipients are required to present their work to the Research Leadership Committee before the start of the project and to the Department at the conclusion of their grant.

Helpful Resources

For guidance and advice on the research process and resources, contact Sarah Corey.


For a Department of Anesthesiology Biostatistical consult, please follow this link or send an email to Kara Fields.


Partners Pulse Login Page for access to training/learning modules


Perioperative Data Group

(requires Partners login to access)


Research Navigator Login Page


Committee on Human Research (IRB) resources

(requires Navigator login to access)


New Support Services | MGB Human Research Affairs - IRB:


MGB IRB | Office Hours | Mondays | 10:00AM – 1:00PM | Zoom

Do you have a quick question that you would like to run by an IRB Specialist? Join the MGB HRA/IRB Office Hours: Drop in any time between 10am and 1pm on Mondays to get your questions answered.

Join on Zoom here: https://partners.zoom.us/j/84612060129

 

MGB IRB | Consult Service

Would you like in-depth, individualized support for your new or existing IRB protocol? Complete the REDCap form and one of our IRB Specialists will contact you within 2 business days to arrange a time to discuss.

 

MGB IRB | Determinations for “Not Human Subject Research” (NHSR) Including Quality Improvement (QI) Research

Are you looking for a NHSR determination or trying to determine if your study falls under QI? Complete the REDCap form and an IRB Specialist will review your case and provide the necessary documentation. Visit the IRB Services page for additional information.

 

IRB Helpline: 857-282-1900 / IRB Mailbox: irb@partners.org

Publications

Click here to view our department's publications from August- November 2022