The RNA Transcript, October 31, 2022

News

Introducing the 2022-2023 RNA Student Postdoc Council

The 2022-2023 RNA Council is comprised of seven graduate students and three postdocs across U-M. The objective of the RNA Student Postdoc council is to work collaboratively across disciplines, build a scientific community, and generate ideas and activities that advance RNA research and education across the University of Michigan.

The Council was created at the recommendation of our Executive Committee. While the group has financial support from the Center, it has also secured an ‘RNA Salon’ grant from The RNA Society. These grants provide additional funds to support new and exciting initiatives created by the RNA Council.

Last year, the council met for its first Pub Science event as well The RNA Function, a trainee networking event. The Council has created U-M RNA Resources in the form of an RNA Skill Share program and launched a Technique Demo video series, a series of videos that explain RNA techniques, the first one is about Total RNA Extraction.

Melissa J. Moore, chief scientific officer at Moderna recommended for honorary degree at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement.

Three leaders in the fields of international finance, higher education and medical research are being recommended for honorary degrees at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement.

Moore’s contributions in medical research have been fundamental in the fight against COVID-19. From 2016-21 she led the early-stage research teams developing Moderna’s platform technologies in mRNA design and delivery. These technologies were foundational for Moderna’s ability to rapidly create a highly effective vaccine against SARS-CoV-2.

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U-M Department of Biological Chemistry

Single Particle Cryo-EM of TRPV1: From Atomic Structures to Gating Mechanism

Yifan Cheng, UCSF

Tuesday, November 1, 2022

12:00 - 1:00 p.m.

Medical Science Unit I - 5330 MS I  

U-M Oral Dissertation Defense

Computational Tools for Protein-Protein Interaction Prediction and Analysis

Eric Bell, Advisor: Peter Freddolino

Tuesday, November 1, 2022

3:00 - 4:00 p.m.

Palmer Commons, Forum Hall

U-M Center for Cell Plasticity and Organ Design (COPD)

International Symposium and Poster Session

PDF flyer

Wednesday, November 2, 2022

10:00 a.m. - 6:00 p.m.

event details and registration

RNA Collaborative Seminar host: Harvard Initiative for RNA Medicine

U-M Oral Dissertation Defense

Development and Discovery of Novel Inhibitors of Mycobacterium tuberculosis RNA Polymerase for the Treatment of Tuberculosis

Shireen Ashkar, Advisor: George Garcia

Friday, November 4, 2022

4:00 - 5:00 p.m.

CCCB 0420

U-M Human Genetics

Gene Discovery and the Promise of Precision Medicine in Epilepsy Heather Mefford, Pediatric Neurological Disease Research, St. Jude Children’s Research Hospital

Monday, November 11, 2022

12:00 - 2:30 p.m.

BSRB, Kahn Auditorium

U-M Medical School

ROMS Virtual Information Session

The Research Operations, Management & Strategy (ROMS) Fellowship is a two-year, paid, full-time position at the U-M Medical School designed to transition biomedical trainees from the bench to careers in research operations and administration through a series of unit rotations, hands-on learning experiences, and direct mentorship from leaders in the field.

Monday, November 14, 2022

1:00 - 2:00 p.m.

event details and registration

U-M Michigan Institute for Data Science (MIDAS)

Annual Data Science and AI Summit

Don't miss the kick-off of The Eric and Wendy Schmidt AI in Science program, with faculty vision talks, showcase of U-M data science and AI research organizations, and lots of networking opportunities!

November 14-15, 2022

Rackham Building

event details and registration

Job Opportunities

Join the University of Michigan Center for RNA Biomedicine! 

A fabulous community of faculty, students & researchers. We have two open positions in our team:

RNA Center Program Manager: https://careers.umich.edu/job_detail/225431/rna-center-manager

Administrative coordinator: https://careers.umich.edu/job_detail/225397/administrative-coordinator

Stephanie Moon Lab (U-M) seeking postdoc

to lead a project on molecular mechanisms of aging & neurodegeneration with state-of-the-art microscopy & RNA biology

APPLY HERE

Carine Tisné lab (Paris, FR) seeking postdoc in RNA maturation

Postdoctoral position (2 years) in the group “RNA biogenesis, architecture and interactions” led by Carine Tisné in the Institute of Physico-chemical Biology (IBPC) to work on RNA maturation APPLY HERE

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.

Below are recent highlights.

Grayeski, P. J., Weidmann, C. A., Kumar, J., Lackey, L., Mustoe, A. M., Busan, S., Laederach, A., & Weeks, K. M. (2022). Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA. Nucleic acids research, 50(17), 9689–9704. doi.org/10.1093/nar/gkac739

Magnuson, B., Bedi, K., Narayanan, I. V., Bartkowiak, B., Blinkiewicz, H., Paulsen, M. T., Greenleaf, A., & Ljungman, M. (2022). CDK12 regulates co-transcriptional splicing and RNA turnover in human cells. iScience, 25(9), 105030. doi.org/10.1016/j.isci.2022.105030

Pham, V. V., Gao, M., Meagher, J. L., Smith, J. L., & D'Souza, V. M. (2022). A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Communications biology, 5(1), 819. pubmed.ncbi.nlm.nih.gov/35970937

Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688