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Paola Arlotta, Ph.D.
Golub Family Professor of Stem Cell and Regenerative Biology, Harvard University
Chair of the Department of Stem Cell and Regenerative Biology; Associate Member, Stanley Center for Psychiatric Research, Broad Institute
Dr. Paola Arlotta is a professor of stem cell and regenerative biology at Harvard University, and Chair of HSCRB. She is a principal faculty member at the Harvard Stem Cell Institute, an institute member at the Broad Institute, and an associate member of the Stanley Center for Psychiatric Research at the Broad Institute.
Focusing on the developing cerebral cortex, the Arlotta lab has had a long-standing interest in discovering the mechanistic principles that govern the establishment and maintenance of cellular diversity and its integration into working networks that subserve cortical function. While mice are instrumental for this basic work, the cortex has diverged dramatically in primates, and there is limited knowledge of development of the human cortex. Motivated by understanding how our own cortex develops and how human neurodevelopmental disease emerges, the lab has built on their basic program in the mouse to instruct, validate and study human cortical development in vitro, within 3D cortical organoids of unprecedented complexity and reproducibility.
Collectively, the Arlotta lab research program explores the interface between development and engineering of the neocortex, to gain fundamental understanding of both the principles that govern normal cortical development and of previously-inaccessible mechanisms of human neurodevelopmental disease.
Dr. Arlotta received her M.S. in biochemistry from the University of Trieste, Italy, and her Ph.D. in molecular biology from the University of Portsmouth in the UK. She subsequently completed her postdoctoral training in neuroscience at Harvard Medical School.
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