CCMBM Summer Update
The Core Center for Musculoskeletal Biology & Medicine (CCMBM) defines itself by emphasizing musculoskeletal-specific education and services that are critical to its members but not available elsewhere in the university system.
|
|
Fig. 1. The CCMBM fosters a collaborative research environment. Lifetime analysis of publications by CCMBM investigators, comprising the X and Y axes, indicates co-authorship with a heatmap, with a 28% increase in the current cycle of the NIH P30, which coincides with establishing the CCMBM.
|
|
CCMBM leadership, faculty, and staff, spent much of the spring hard at work on the center's P30 renewal application and progress report. Thank you for your support of the application in completing the surveys and providing biosketches customized for the CCMBM. Now that it has been submitted, we wanted to share some of the most exciting facts and figures from the report. |
|
CCMBM membership grew from 114 to 161 (41%). |
|
Grant funding to CCMBM investigators increased 2.4x from $65M to $156M. |
|
CCMBM investigators authored over 550 MSK-related research publications. |
|
The number of publications coauthored by CCMBM investigators increased by 28%. |
|
|
Osteoporosis is a major public health concern acting as a leading cause of morbidity and mortality in our aging population and affecting over 200 million people worldwide. The financial burden from the costs of osteoporotic fractures is increasing at alarming rates. As current therapies for osteoporosis have numerous shortcomings, the development of new osteogenic therapies is imperative. Cell-mediated therapy using mesenchymal stem cells (MSCs) holds great promise for skeletal disorders. However, its reported clinical outcomes have been suboptimal, requiring a more precise understanding of the molecular and epigenetic regulatory mechanisms for MSC differentiation.
|
|
|
Earlier this month, the inaugural cohort of STRETCH mentors and scholars met with CCMBM staff and UC LEADS representatives to officially launch their research projects. Scholars and mentors represent a network of MSK research spanning 6 of the UC campuses: Berkeley, Davis, Los Angeles, Merced, Riverside, San Francisco.
The STRETCH program stimulates collaboration among scientists by supporting students throughout a two-year research experience that incorporates two academic years and one summer of research at the home campus, and a second summer of research at another UC.
Learn more about the program here. |
|
TEAM 1: Fibroadipogenic Progenitors as Mediators of Muscle Fibrosis
|
|
STRETCH Scholar
Sonali Feeley
UC Los Angeles
|
|
Mentor
Brian Feeley, MD
UC San Francisco
|
|
Mentor
Thomas Rando, MD, PhD
UC Los Angeles
|
|
TEAM 2: Assessing Spinal Movement Quality in Lower Back Pain |
|
STRETCH Scholar
Miriam Contreras Castillo
UC Riverside
|
|
Mentor
Jeannie Bailey, PhD
UC San Francisco
|
|
Mentor
Grace O'Connell, PhD
UC Berkeley
|
|
Mentor
Elena Kokkoni, PhD
UC Riverside
|
|
|
TEAM 3: Studies in "Osteoimmunology" |
|
STRETCH Scholar
Rida Mirza
UC Merced
|
|
Mentor
Gabriela Loots, PhD
UC Davis
|
|
Mentor
Jennifer Manilay, PhD
UC Merced
|
|
L-R: Victor Cheuy, PhD with Best Slam Talk & Postdoc/Resident Poster winner Steven Garcia, MD. |
|
This year, the NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted attendees in person and online for their annual retreat. Co-sponsored with the UCSF Department of Orthopaedic Surgery and REACH, A Picture of Pain: Advances in Management and Treatment drew over 150 attendees to join the 23 invited speakers and moderators during February 28-March 1, 2023.
The first day of the retreat opened with a talk from keynote speaker Kate Nicholson, JD, Founder and Executive Director of the National Pain Advocacy Center (NPAC) titled “Advocacy, Equity, and the Lived Experience of Pain.” This was followed by a panel discussion featuring members of the Integrated Pain Team at the San Francisco VA Medical Center and a slam talk competition featuring five UCSF trainees. Orthopaedic Surgery Resident Steven Garcia, MD, took home this year's prize for Best Slam Talk.
|
|
|
|
Fueling MSK Health and Discovery with Data Science, High Tech, and Digital Health
Mark your calendars for the CCMBM/Department or Orthopaedic Surgery Spring Scientific Retreat scheduled for March 12-13, 2024. Location will be at UCSF Mission Bay Campus, Genentech Hall. Event details will be forthcoming as we draw closer to the retreat.
|
|
|
|
MD/PhD Student
Alliston Lab, Department of Orthopaedic Surgery
Award: JIC Travel Award
February 2023 - Orthopaedic Research Society Annual Meeting
|
|
|
|
Professor of Medicine and Dermatology
School of Medicine
Project: "The impact of abaloparatide on stem cell function during fracture repair"
Award: RAP Pilot & Feasibility (REAC)
|
|
|
|
Postdoctoral Scholar
Fields Lab, Department of Orthopaedic Surgery
Project: "Biochemical mechanisms affecting T1ρ relaxation times in the intervertebral disc"
Award: Tools & Technology Grant
|
|
|
|
Postdoctoral Scholar
Kazakia Lab, Department of Radiology and Biomedical Imaging
Project: "Machine learning methods for denoising and fusion of mask musculoskeletal images”
Award: JIC Grant Development Award
|
|
|
|
Professor of Preventative and Restorative Dental Science
School of Dentistry
Project: "Sustainable partnership through correlative workflows between the BBCMC and the BIDC imaging facilities"
Award: RAP Pilot & Feasibility Grant (COIA)
|
|
|
|
Postdoctoral Scholar
Fields Lab, Department of Orthopaedic Surgery
Award: JIC Travel Award
March 2023 - The Minerals, Metals & Materials Society (TMS) Annual Meeting
|
|
|
|
Assistant Professor of Medicine
SFVAMC Staff Physician
Project: "Bone marrow fat and skeletal health in type 2 diabetes"
Award: RAP Pilot & Feasibility Grant (CCMBM)
|
|
|
|
Clinical Fellow
Rheumatology, Department of Medicine
Award: JIC Travel Award
May 2023 - SPARTAN Annual Meeting
|
|
|
|
Assistant Professor of Radiology
Department of Radiology and Biomedical Imaging
Project: "Integration of markerless motion correction and high-temporal resolution technologies for fast, robust, sub-millimeter gSLIDER fMRI at 3T"
Award: RAP Pilot & Feasibility Grant (Academic Senate)
|
|
|
|
DUE FRIDAY!
Application deadline: June 30, 2023, 5:00pm PST
CCMBM is pleased to announce the CCMBM Fall 2023 Junior Investigator Travel Award, which is intended to support the travel of trainees to develop expertise, network, or acquire skills in a field at a scientific conference that the applicants may otherwise be unable to attend. The award is particularly designed to encourage travel to a conference where the trainee may not be presenting an abstract, but where interactions with other attendees and participation in conference activities can serve as a springboard for trainees to transition to the next stages in their scientific careers.
|
|
|
|
Awards Given on a Rolling Basis - Apply Today!
We have three more awards available in this grant year and will be awarding them on a rolling basis until all funds have been used.
The Grant Development Award provides funding for a junior CCMBM member to host a meeting (e.g., lunch or dinner) with 2-3 UCSF faculty members who are outside of the trainee’s current lab to:
1) brainstorm/solicit informal feedback on a study idea or research direction
2) learn about the latest methods and techniques used in related fields
3) identify potential collaborators
4) promote inter-disciplinary MSK research
5) expand the trainee’s professional network
|
|
|
|
Submission deadline: October 2, 2023, 2:00pm PST
The Resource Allocation Program (RAP), an umbrella consortium of UCSF funders that coordinates multiple intramural research funding opportunities, is now accepting applications for the Fall 2023 Cycle. Review the grant-specific descriptions/instructions for the grant mechanism you are applying, not the funding agency. Funding agencies will select the awardees by choosing the proposals that best fulfill their programmatic goals. Simultaneous consideration of each application by multiple funding agencies enhances funding likelihood. Funding results will be available by December 2023. See CCMBM Funding Opportunities for the RFA.
|
|
|
|
Recognizing the need for collaboration of MSK scientists with experts outside of the MSK field, we are providing support to MSK Center members to host a meal for a creative and enjoyable in-person networking meeting to stimulate these interactions and to further develop new research ideas and plans to fund them. Faculty, staff, and trainees who are MSKC/CCMBM members are encouraged to apply to host an event.
|
|
Core Center for Musculoskeletal Biology and Medicine (CCMBM), 513 Parnassus Avenue, S-1161, San Francisco, CA 94143 |
|
|
|
|
|
|
