The RNA Transcript, September 19, 2022 | |
Explore Nascent RNA with Bru-seq technologies | |
The University of Michigan Bru-seq Lab is a core facility that provides nascent RNA sequencing services. We serve researchers from the University of Michigan, and other institutions in the United States and around the world.
Bru-seq lab Core Services include:
- Total RNA and nascent Bru-RNA isolation
- cDNA library preparation
- Paired-end 150bp Next-Generation Sequencing
- NGS data processing
- Data storage
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U-M Center for Cell Plasticity and Cell Design (CPOD) | | |
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Chromatin at the nexus of epithelial development, differentiation, and cancer
Brian Capell, University of Pennsylvania
Tuesday, September 20, 2022
4:00 - 5:00 p.m.
BSRB, ABC with zoom option
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U-M Drug Discovery 2nd Annual Symposium | | |
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The second Annual U-M Drug Discovery Symposium aims to highlight success stories from the U-M drug discovery community. The symposium allows faculty and trainees to share best practices and network with others involved with drug discovery research.
Wednesday, September 21, 2022
9:00 a.m. - 4:00 p.m.
event details and registration
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RNA Collaborative Seminar, hosted by The NCI RNA Biology Initiative | |
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Wednesday, September 21, 2022
4:00 - 5:00 p.m.
Zoom link
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Re-wiring of RNA methylation by oncometabolites in kidney cancer
Pedro Batista
AGO2 unchained: in vivo roles in the miRNA pathway and beyond
Joana Vidigal
Moderator: Sandra Wolin
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Structure and Function of a Bacterial Histone Lysine Methyltransferase in Pathogenesis: How Bacteria Read and Write Histone Modifications
Raymond Trievel, Biological Chemistry
Friday, September 23, 2022
10:00 - 11:00 a.m.
LSI Library
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U-M RNA Innovation Seminar | | |
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Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ
David Shechner, University of Washington
Monday, September 26, 2022
4:00 - 5:00 p.m.
BSRB, ABC with zoom option
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U-M DCMB 10th Anniversary Symposium and Celebration | | |
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Science Talks and the 8th Annual Gilbert S. Omenn Lecture
Data Science and Medicine in the Age of Open Data, Open Code, and Open Access: From Protein Structure Prediction to COVID Origins
Holden Thorp, Ph.D., Editor-in-Chief, Science
Thursday, September 29, 2022
1:15 - 6:30 p.m.
event details and registration
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NCCAT CryoEM Current Practices Webinar | | |
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Conformational Change of Methylenetetrahydrofolate Reductase in the Allosteric Regulation: Crystal Structure of Eukaryotic MTHFR in Complex with S-Adenosylmethionine
Kazuhiro Yamada, Markos Koutmos Lab
Friday, September 30, 2022
10:00 - 11:00 a.m.
LSI Library
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U-M Bioinnovations in Brain Cancer | | |
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Sep 30 – Oct 1, 2022
Ann Arbor, MI
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U-M Oral Dissertation Defense | | |
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Development and Analytical Characterization of Lipid-Based Nanoparticles
Minzhi Yu, advisors: Anna Schwendeman and Steve Schwendeman
Monday, October 3, 2022
1:00 - 2:00 p.m.
NCRC Building 10-G065
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Novel Structure of a Type I Polyketide Synthase Reductive Cassette
Tyler McCullough, Janet Smith Lab
Friday, October 7, 2022
10:00 - 11:00 a.m.
LSI Library
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Midwest Oligonucleotide Therapeutics Symposium | | |
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The Midwest Symposium on Oligonucleotide Therapeutics is a grassroots meeting in Indianapolis supported by an Oligonucleotide Therapeutics Society (OTS) Local Delivery Grant.
October 8 – 9, 2022
Indianapolis, IN
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25th anniversary screening of GATTACA with Panel Discussion | | |
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Co-sponsored by Neurology, Human Genetics, and the Center for RNA Biomedicine
Monday, October 10, 2022
6:30 - 9:00 p.m.
Michigan Theatre
Ann Arbor, MI
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RNA Society of North Carolina Symposium | | |
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The symposium will feature world-class speakers, talks from submitted abstracts, and many great opportunities for networking. Abstract deadlines are Sept 16th (to be considered for talks) and Sept 26th for posters.
October 13–14, 2022
Durham, NC
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The "structural" journey of a ribonucleoprotein complex: From molecules to droplets
Rishav Mitra, James Bardwell Lab
Friday, October 14, 2022
10:00 - 11:00 a.m.
LSI Library
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Rustbelt RNA Meeting 2022 | | |
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October 14–15, 2022
Cleveland OH
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Scientist/Sr Scientist RNA Structural Biology
Join Arrakis Therapeutics on it's mission to bring powerful new RNA-targeted small molecule (rSM) medicines to millions of patients.
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Job Responsibilities
- Design and prepare RNA constructs for investigation of RNA and RNA-ligand complexes by X-ray crystallography, atomic force microscopy and other structural biology techniques
- Perform structural study experiments, analyze, interpret, and effectively communicate results to project teams
- Contribute to multiple projects in parallel in collaboration with cross-functional teams to inform development of RNA-targeting small molecules
- Interface with CROs, academic collaborators and RNA Biochemistry team • Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences
- Contribute to Arrakis’ scientific publications and patent applications
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights.
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McLean, E. K., Nye, T. M., Lowder, F. C., & Simmons, L. A. (2022). The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria. Annual review of microbiology, 76, 461–480. doi.org/10.1146/annurev-micro-102521-014450 | |
Pham, V. V., Gao, M., Meagher, J. L., Smith, J. L., & D'Souza, V. M. (2022). A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Communications biology, 5(1), 819. pubmed.ncbi.nlm.nih.gov/35970937 | |
Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688 | | | | | |
