Tips to Maximize your Results with Respen-A™ |
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Welcome to our Respen-A™ newsletter, a way for us to share tips on how to maximize the benefits of the Respen-A™, to feature upcoming events, and to introduce you to some of the people whose lives have been changed due to this Homeopathic Treatment! Please read on, and share... |
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UPDATES!
CORRECTIONS/CLARIFICATIONS...
In our February 2023 newsletter, under updates, we shared that wearing the PST disc all day and overnight could cause lower back pain. We want to clarify that statement. It is only when you are wearing the PST disc together with the Respen-A™ disc, which some parents find works best for their child, that lower back pain can happen. This is only because the PST disc clears phenols out of the way and makes the MAO-A, as activated by the Respen-A™, that much more effective. Because of this added effectiveness, the Respen-A™ pushes more calcium into the bones. Therefore, if you are only supplementing 2000 mg calcium carbonate daily, you will be depleting more calcium than you are replacing. If you increase your calcium supplementation by 200 mg to 400 mg of elemental calcium daily, then that should replace the extra calcium depletion, and lower back pain will not occur. PLEASE SEE INFO UNDER ASK ELAINE FOR THE PARTICULARS REGARDING ELEMENTAL CALCIUM.
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I'm here to help...
Elaine likes to refer parents to me for advice as my son was one of the first two children to use Respen-A™. Together, my son, Tyler (now 18), and I have had years of experience. Having spoken with well over one hundred parents, I believe that the most common topic covered is that parents of autistic kids have no hope after trying SO many things that they'd hoped would work.
While I was lucky enough to free my son from the trap of autism with the very first- and only- treatment we tried, Respen-A™, it had taken me over a year to take him in to be diagnosed to begin with, a year AFTER I'd been advised by a pre-school teacher and two friends to do so. I was just so exhausted as a mom with two toddlers to even consider adding something else to my plate.
Having had my own experience of a diagnosis of Multiple Sclerosis, that was actually 100% Lyme Disease, and decades of people telling me what I could do to cure it, easily having spent over $75,000 towards that endeavor without any results, I know how parents feel. I had lost hope by the middle of 2018 and was ready to resign myself to in-home care and being bedridden. Then I learned of someone new in our valley who had gotten rid of Lyme disease in himself and others. Still in despair, I waited four months before booking an appointment, but optimism won out. Seeing this practitioner was the first day of my new life; Western Medicine labels dissolved, and my Lyme disease was GONE nine months later.
I'm here to tell you that, with Respen-A™, it is o.k. to hope again. You might not see instant results like I did with my son, but then again you may. Some parents see one gain a day, others one a week. Even for us, things continued to get better and better. Sometimes we had stumbling blocks, too. I've always felt that, if I'd only seen one gain, it would be totally worth it to continue using Respen-A™.
I recommend writing down every positive change you see. Call Elaine, or me, always (we are your lifelines!), with any question or concerns. We'll know what is missing or needed based on your results. The journey is worth it! Just look at the two videos of my son, Tyler, link below, for proof. The video is a combination of him on the couch having a conversation with me, and him after not using the Respen-A™ for 2 days. The stark differences show full life vs. being stuck in the trap of autism.
Please let me know how your journey goes!
(submitted by Kerri McCormick)
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THAT'S A GOOD QUESTION...Ask Elaine
Elaine, you've said that calcium must have something to bind to. Therefore, the label should specify how much elemental calcium is in each serving size. The front of the label of the calcium that I’ve been using now reads 600 mg per tablet. The back of the label just reads calcium, and one tablet per serving size. I don’t see 'elemental calcium' anywhere on the label.
Several different kinds of calcium compounds are used in calcium supplements. Each compound contains varying amounts of calcium — referred to as elemental calcium. Elemental calcium is the necessary component considered when replacing the 2000 mg of calcium that is pushed out of your body, each day, when using Respen-A™. Common calcium supplements may be labeled as:
- Calcium carbonate (40% elemental calcium)
- Calcium citrate (21% elemental calcium)
- Calcium gluconate (9% elemental calcium)
- Calcium lactate (13% elemental calcium)
If the label does not reference 'elemental calcium' then use the above percentages to calculate that based on the form of calcium you choose.
The two main forms of calcium supplements are carbonate and citrate. Calcium carbonate is least expensive and therefore often a good first choice. Other forms of calcium in supplements include gluconate and lactate. As you can see from the above chart, calcium carbonate will be the easiest form to use because of the amount of elemental calcium that each tablet contains. You'd typically be swallowing 8 tablets per day. IF you prefer calcium lactate, you would need to swallow 73.25 tablets EACH DAY!
In addition, some calcium supplements are combined with vitamins and other minerals. For instance, some calcium supplements may also contain vitamin D or magnesium. Check the ingredient list to see which form of calcium your calcium supplement is, and what other nutrients it may contain. This information is important because vitamin D at over 400 iu's per day will inhibit MAO-A. Also, if magnesium is included, it is usually at greater than a 1:4 ratio to the calcium, which means you would have a greater chance of diahrrea.
When looking at calcium supplements, remember to consider these factors:
Amount of calcium
Elemental calcium is important because it's the actual amount of calcium in the supplement. It's what your body absorbs for bone growth and other health benefits. If you are using Respen-A™, you will need 2000 mg of elemental calcium per day to replace what the Respen pushes out. The Supplement Facts label on calcium supplement is helpful in determining how much calcium is in one serving. As an example, calcium carbonate is 40% elemental calcium, so 1,250 milligrams (mg) of calcium carbonate contains 500 mg of elemental calcium. Be sure to note the serving size (number of tablets) when determining how much calcium is in one serving.
Tolerability
Calcium supplements cause few, if any, side effects. But side effects can sometimes occur, including gas, constipation and bloating. In general, calcium carbonate is the most constipating, but because magnesium is a necessary component to make calcium work, the 1:4 ratio in relation to calcium resolves this issue.
What forms of caLcium are preferred for use with Respen-A™?
Calcium Carbonate. Not only is it the least expensive but it has the most elemental calcium, which means the fewest number of tablets to supplement daily.
What forms of magnesium are preferred for use with Respen-A™?
If a parent wants to use a different form of magnesium other than magnesium oxide, I would ask, why? Magnesium oxide has the oxide ion, which is needed by MAO-A to make the electron transport chain work. The oxide ion pulls the hydrogen down the electron transport chain to make water for the cells. If you’re worried about becoming dehydrated, removing this oxide ion would be a major concern!
Can I use an ubiquinol spray to support the mitochondria?
Ubiquinol naturally occurs in the body at the cellular level, but it is no good unless you make adequate ATP. Ubiquinol is like the janitor in the cell. It binds to flawed proteins to recycle them. The body makes flawed proteins. That’s just the way it is, kind of like an assembly line gone wrong. These flawed proteins then litter the cell, like trash. To get the trash recycled, you need ATP. You need MAO-A to make ATP. If you don’t have your MAO-A working in the body, then you are compounding the problem. Excess ‘trash’ in the cells causes them to swell. Supplementing with ubiquinol is worthless and expensive. Your body already makes it, and as long as you have the MAO-A activated, then it can do its job. Activating MAO-A also allows the mitochondria to functioning properly. See Elaine's article and Have You Heard, below, for more support.
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Mitochondria and MAO-A
I would like to share what we have learned from our research, as it supports the research done by Dr. Naviaux. We, too, have found that the root of autism lies at the mitochondria, specifically deficient monoamine oxidase-A (MAO-A) activity. MAO-A is genetically expressed as a high or low activity allele on the X-chromosome. The low activity MAO-A allele has been shown to be associated with ASD. Those with a low activity allele are more susceptible to inhibition of the MAO-A activity by environmental factors. MAO-A activity is inhibited by stress, lipid peroxidation, high estrogen, heavy metals such as aluminum, mercury, cadmium and chronic high copper levels.
There are two isoforms of MAO; MAO-A and MAO-B. MAO-A metabolizes histamine, serotonin and norepinephrine, and MAO-B metabolizes dopamine. Interestingly, research in 1986 by Palmer et al has shown that these monoamine aldehyde metabolites are physiologically active. Thus, instead of the catecholamines and indoleamines being the active neurotransmitter, it is more likely that the aldehyde metabolites are the active agonist on the post synaptic receptors. MAO-A metabolizes; histamine into the active H2 agonist, telemethylimidazoleacetaldehyde; serotonin into its active aldehyde, 5-HIAL; and norepinephrine into its active aldehyde, DOPEGAL. Medicine has assumed that, for instance, low levels of the serotonin excreted metabolite 5-HIAA in the urine indicates low serotonin levels, but research actually shows that 5-HIAA levels do not indicate serotonin concentrations but rather reflect MAO-A activity.
When the ratio of MAO-A:MAO-B is decreased, it results in mitochondrial dysfunction by inhibiting the alpha-ketoglutarate dehydrogenase enzyme and the NADH dehydrogenase enzyme. Inhibition of the alpha-ketoglutarate dehydrogenase results in impaired Acetyl CoA production. This results in increased conversion of pyruvate to alanine. Increased alanine levels inhibit MAO-A activity. Inhibition of NADH dehydrogenase results in impaired transfer of electrons to the electron transport chain. Inhibited NADH dehydrogenase activity also results in decreased oxidation of NADH to NAD resulting in decreased superoxide ion production which is needed to pull the electrons down the electron transport chain. Inhibition of NADH dehydrogenase results in lactic acid production. Increased levels of lactic acid and the decreased oxygen consumption by the mitochondria can trigger the cell danger response. The increase in lactic acid results in increased calcium influx resulting in mast cell hypersensitivity, inflammation and cell destruction. This increase in calcium influx also explains the increased risk of seizures in the ASD population.
This scientific rationale is the basis for our development of the treatment, Respen-A™. Respen-A™ is a homeopathic dilution of reserpine which has been shown to double the activity of MAO-A. Respen-A™ has been prescribed as a compounded treatment to over 900+ ASD patients and no adverse side effects. A small study of ASD patients (N=9), average age 13.5 years, showed significant improvement in ATEC scores (p<0.001) using the Respen-A™ for 3 months.
So the next question to ask is why the rapid increase in ASD? I hypothesize that it is multi-factorial, but what sets up the “perfect storm” for the development of autism is the use of epidurals during childbirth coupled with inheriting the low activity MAO-A allele. Let me explain the basis of my hypothesis. As mentioned above, MAO-A metabolizes serotonin into its active aldehyde, 5-HIAL. If MAO-A activity is decreased, the serotonin in the nerve synapses will build up, and increased serotonin concentrations in the nerve synapses inhibit oxytocin neuron growth. Note that studies have shown an increased risk of autism in the offspring of mothers who used antidepressants during their pregnancy. In utero, as the neurohypophyseal system grows, it produces vasopressin, which is converted to oxytocin as it travels down the neurohypophyseal plexus. The longer the neurohypophyseal system grows, the more oxytocin is produced. When the oxytocin reaches a specific concentration, it tells the neurohypophyseal plexus to stop growing. This is not supposed to happen until about 7-10 days postpartum. Note that research has shown that ASD patients have an immature neurohypophyseal plexus. When a mother receives an epidural during childbirth, almost always they are administered Pitocin (synthetic oxytocin), and this is usually continued through the delivery stage. The anesthetics used in the epidurals, Bupivacaine and more recently Ropivacaine, compete with Pitocin for breakdown by the Cytochrome p450 3A4 enzyme in the liver. Note that boys genetically have less of the Cyp450 3A4 enzyme than girls. This competition for the Cyp450 enzyme results in Pitocin remaining at higher levels longer which could become high enough to trigger the neurohypophyseal system to stop growing resulting in decreased oxytocin neuron growth and production. The use of epidurals and rate of autism mirrored each other until 1996 when autism spiked drastically. Interestingly, 1996 is when Ropivacaine came on the market and became the most used anesthetic in the epidurals. Ropivacaine requires twice as much Cyp450 3A4 enzyme activity to metabolize it as does Bupivacaine. Research shows that MAO-A is integral in the neurochemical architecture of the neurohypophyseal system. The hypothalamus-neurophypophyseal system is involved with releasing oxytocin during stress and to maintain homeostasis.
Besides the environmental factors mentioned above that inhibit MAO-A activity, I have also identified some parasites that inhibit the gene expression of MAO-A.
Submitted by Elaine DeLack
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Have you Heard?
A decrease in the MAO-A activity can decrease the mitochondrial complex II activity (reduced flavin adenine dinucleotide (FADH)) as it is dependent on the MAO-A activity (Heron et al, 2001). Inhibition of mitochondrial complex II results in an accumulation of dopamine’s metabolite HVA (Cakala et al, 2006). HVA is elevated in ASD patients (Gillberg & Svennerholm, 1987).
Potential Adverse Reactions: The only side effect that has been reported with the use of Respen-A™ in children with ASD has been increased motor activity, such as hyperactivity particularly if used in conjunction with some antidepressants, which has been resolved by discontinuing or decreasing the antidepressants or reducing the dose of Respen-A™.
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FREE one month supply of Respen-A™ to New Users!
Elaine is offering one month of Respen-A™, FREE to new users. This is a $50 savings!
We want every parent to experience the joy of recovering their child from autism, ADD/ADHD, anxiety, depression, bipolar disorder, and more, so tell your friends and people you know about this special offer!
You'll pay for shipping (shipped USPS Priority Mail in the U.S.A.). Order ships upon payment.
Please help us help others by telling your friends about this opportunity to try Respen-A™, FREE, and help us to change the face of autism! Tell them to send their request for this offer to Elaine at elaine.delack@gmail.com.
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DID YOU KNOW...
If you are using Puritan pride calcium 600 mg, then you will need to supplement eight tablets in order to replace 1920 mg of elemental calcium, daily.
If you are using NOW brand calcium powder, then you will need to supplement 4 teaspoons daily In order to get 1920 mg of elemental calcium.
If you are using Spring Valley calcium carbonate 600 mg then you will need to supplement tablets in order to replace 1920 mg of elemental calcium, daily.
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Did you know that we are offering 3 months of FREE RESPEN-A™?
How to get it: send us a before and after video of you or your child on Respen-A™ that we can post on our www.respen-a.com website under testimonials, and on our Facebook page.
This offer is valid WORLD-WIDE. Simply upload your video to YouTube or Vimeo, then send us the link at elaine.delack@gmail.com.
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TOGETHER, WE CAN
CHANGE THE FACE OF AUTISM!
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Please stay tuned for our June 2023 Newsletter! |
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| MedDEV-OTC Inc. | 425-870-9366 | elaine.delack@gmail.com | www.respen-a.com |
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