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CCMBM Cores:
Featured Services
The Core Center for Musculoskeletal Biology & Medicine (CCMBM) defines itself
by emphasizing musculoskeletal-specific education and services that are critical to its members but not available elsewhere in the university system.
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"The expertise provided by the CCMBM Skeletal Biology and Biomechanics (SBB) Core Director, Dr. Wenhan Chang, has been instrumental in publishing several important studies in the journals of Bone and Nature Cell Biology. My lab has also piloted a new study with the help of the SBB Core’s expertise on bone and murine tooth morphogenesis and the Ex Vivo µCT Service that is available to all CCMBM members."
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Looking for a novel way to rapidly and quantitatively evaluate gene expression? The Nanostring nCounter fills the gap between qPCR and RNAseq by analyzing up to hundreds of transcripts at a time with small amounts of RNA. Nanostring uses fluorescent color-coded barcode probes and single molecule imaging to detect and count hundreds of unique transcripts in a single reaction at high sensitivity (< 1 copy per cell). Starting with 50 - 100ng total RNA, no enzymatic processing steps are required for gene expression analysis. The probes hybridize to approximately 100 bases, and can be multiplexed to detect up to 800 different targets in a single reaction. Pre-built CodeSets are commercially available, as well as custom UCSF Skeletal Biology custom CodeSets that survey 94 or 627 mouse genes implicated in musculoskeletal biology, including bone, cartilage, tendon and muscle.
For more info on the custom UCSF codesets, please see our website. For inquiries, please contact Chia-Ling Tu.
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The UCSF Department of Orthopaedic Surgery Grand Rounds are held on Wednesday mornings at 7:30am.
Watch the recordings from this year's 2021-2022 Grand Rounds Lecture Series and subscribe for updates.
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Did you miss our last seminar, scientific retreat, or technical workshop? Or are you looking for imaging equipment or skeletal biology standard operating protocols? Members have access to workshops, seminars and retreat session recordings, protocols, and archived newsletters on the CCMBM Members Only Site. Never miss out on all things related to the Center!
For login assistance or questions on the members only site, inquire with Mary Tran.
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The Imaging Core is offering service discounts to Early Stage Investigator and Trainee members. The Epidemiology, Biostatistics and Study Design Core is also offering up to 6 hours of free UCSF Clinical and Translational Institute (CTSI) consultation time for all CCMBM members. Please contact each Core to utilize these member discounts.
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May 18, 10:00-11:00am; Virtual Event
Fiona Powrie, PhD, Professor of Musculoskeletal Sciences, University of Oxford
Translating immunology into new therapies for Inflammatory Bowel Disease
Hosted by the UCSF Biomedical Sciences Graduate Program
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May 20, 12:10-1:00pm; CS-0101
Kevin Magnaye, PhD, Postdoctoral Scholar, Department of Medicine, UCSF
Maternal stress and depression relate to neonatal gut microbiota dybiosis
Cherry Leung, PhD, MSN, CPNP, Assistant Professor, Community Health Systems, UCSF
Associations among gut microbiota and depressive symptoms of adolescents
Hosted by BCMM
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May 20-21; Hilton San Francisco, Financial District
The UCSF Spine Symposium is an annual two-day CME event emphasizing pioneering trends in diagnostic and therapeutic strategies for patients suffering from spinal disorders. The course is designed for neurosurgeons, orthopedists, nurses, physical therapists, physiatrists, anesthesiologists, pain specialists as well as primary care providers.
Hosted by the Department of Neurological Surgery and the Department of Orthopaedic Surgery
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May 23, 9:00-10:00am; N-225
Alexander Rudensky, PhD, Chair, Immunology Program, Director, Ludwig Center at Memorial Sloan Kettering Cancer Center
Hosted by ImmunoX
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May 24, 10:00-11:00am; Virtual Event
Alexis Villani, Graduate Student, Bondy-Denomy Lab, Microbiology and Immunology, UCSF
Elucidating the mechanism of heritable Restriction Endonuclease inactivation (iREN) in Pseudomonas
Hosted by Integrative Microbiology Program
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May 24, 7:00-8:30pm; Virtual Event
Sergio Baranzini, PhD, Professor of Neurology, UCSF Weill Institute for Neurosciences
The Gut-Brain Axis - Gut Microbiome Influences on Neurological Disease
Hosted by BCMM and Osher Mini Medical School
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Application deadline May 24, 11:59 PM EDT
This is an exclusive opportunity for Early Career Investigators to join a cross-disciplinary global research team that tackles a major challenge in human health and disease. Applicants must have obtained their doctorate in science and technology and be involved in active research for 10 or fewer years. In addition, candidates must hold an independent, tenure-track, or equivalent faculty position at a university, private research institution, academic medical center, or national government laboratory. Apply today for this career-defining experience.
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May 25, 7:30am; N-225
Charles Nelson, MD, Chief, Joint Replacement Service, Professor of Orthopaedic Surgery, Hospital of the University of Pennsylvania
Optimizing Outcomes During Revision Total Hip Replacement
Hosted by UCSF Department of Orthopaedic Surgery
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May 25, 4:00pm; Virtual Event
Connie Cepko, PhD, Bullard Professor of Genetics and Neuroscience, Department of Genetics, Harvard Medical School
Mechanisms of Fate Determination in the Vertebrate Retina
Hosted by UCSF Biomedical Sciences Graduate Program
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June 3, 12:30-2:00pm (PT) / 3:30-5:00pm (ET)
Courtney Mazur, PhD, Research Fellow, Wein Lab, Endocrine Unit, Massachusetts General Hospital/Harvard Medical School
Trafficking of mRNA to Osteocyte Dendrites
Janet Lee, MD, MPH, MAS, Assistant Professor of Pediatrics and of Medicine, UCSF
Skeletal Considerations in Transgender and Gender Diverse Youth Receiving Gender-Affirming Medical Therapy
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ACKNOWLEDGING THE CCMBM
If you have received a CCMBM grant, used one of our cores, or formed a collaboration at one of our events that led to a publication, please acknowledge our Center in related publications and presentations. We suggest stating:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number P30AR075055. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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