This email newsletter describes our efforts to substantially reduce cancer deaths.
CCN website
For the website primer tab, we have added an overview page for the infection section. It now lists all the infection topics. New topics include:
Other topics are pending and will be added over the next several months.
Updated grants page
We offer several grants of up to $25,000 - the next deadline is 30 September 2022.
Requirements: proposal should be up to 500 words and include CVs of principal investigators. Email Dr. Pernick at Nat@PathologyOutlines.com.
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Premalignant states for glioblastoma or Hodgkin lymphoma: we welcome your proposals to identify premalignant states for glioblastoma multiforme or Hodgkin lymphoma, based on molecular, not histologic, patterns. As described at Arch Pathol Lab Med 2018;142:558, complexity theory suggests that these states likely exist, even if there is no histologic evidence
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Efficacy of large combinations of therapies to substantially reduce cancer deaths for aggressive lung, colon, pancreatic or breast malignancies, by targeting different aspects of tumor cells, microenvironmental features (vasculature, stroma, extracellular matrix and inflammation) and systemic features (chronic inflammation, immune system dysfunction, hormonal activity, germline changes). See Strategic plan to reduce cancer deaths
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Better understanding of and possibly treatment for physiologic changes associated with cancer deaths shortly after diagnosis. See Curing Cancer Blog - How cancer kills
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Strategies to markedly improve cancer prevention behavior, such as implementing the American Code Against Cancer or other substantial changes to health related behavior
Combinations of therapy:
This article discusses one of our Grants topics - the advantages of combinations of therapy for treatment. These combinations typically work not due to synergy, but because they provide populations of patients, with heterogeneous drug sensitivities, multiple chances to benefit from at least one drug.
LinkedIn and Twitter accounts
Cancer Moonshot updates:
This factsheet discusses President Biden's Cancer Moonshot program, which has a similar goal as our strategic plan to substantially reduce cancer deaths.
What do you think are the important questions that we need to answer or understand in order to substantially reduce cancer deaths?
Here is our current list:
- How can we emphasize the drive to be healthy so that more Americans incorporate healthy habits into their lifestyle?
- Adult cancers are due to decades of systemic changes involving inflammation, the immune system and other networks - how can we most effectively target these changes to reduce cancer deaths?
- What types of prevention activities are likely to bring about the largest reduction in cancer deaths (even if we don’t yet know precisely how to accomplish them)?
- What are potential mechanisms for the large number of pancreatic cancers and the smaller number of lung cancers with no risk factors?
- How can we better detect premalignancy in the lung and pancreas?
What is your cancer plan?
What ideas do you think are most important to consider in order to substantially reduce cancer deaths? All ideas are welcome, however crazy they may sound. Send your thoughts to Nat@PathologyOutlines.com.
Updates to Cancer blog
Latest versions of our documents
(we are working on making these documents easier to navigate):
