RNA Symposium this Friday! |
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Join us this Friday in-person or by zoom for amazing opportunities to connect and collaborate with the U-M RNA research community.
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National Institute of Child Health and Human Development
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Massachusetts Institute of
Technology
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Yale University School of Medicine
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Rosalind Franklin University of Medicine and Science
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SIX U-M DATABLITZ PRESENTERS |
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Graduate Student
Neurology
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Assistant Professor
Human Genetics
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Graduate Student
Bioinformatics
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Assistant Professor
Urology
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Graduate Student
Biological Chemistry
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Assistant Professor
Biological Chemistry
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U-M SCSAP Monthly Seminar Series |
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Integration of single-cell and spatial-seq to gain novel insights into inflammatory skin diseases
Monday, March 21, 2022
1:00 pm - 2:00 pm
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Survival to DNA Damage in Damage-Independent Replication Fork Arrest
Tuesday, March 22, 2022
12:00 pm - 1:00 pm
5150 Biological Sciences Bldg
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----Wednesday, March 23, 2022
----4:00 pm - 5:00 pm
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“The role of PIWI proteins and piRNAs in the eternal life of planarian stem cells”
"U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies"
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U-M DCM&B Tools and Technology Seminar |
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Accelerating structural biology: machine learning tools in cryo-EM
Thursday, March 24, 2022
1:00 pm - 2:00 pm
2036 Palmer Commons
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U-M Taubman Institute Technology Talk |
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The Human Proteome Project: >90% Predicted Proteins Confidently Identified and Advances in Proteo-Genomic Analyses of Cancers
Thursday, March 24, 2022
5:00 pm - 6:00 pm
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U-M RNA Innovation Seminar Series |
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Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease
Monday, March 28, 2022
4:00 pm - 5:00 pm
BSRB, ABC Seminar rooms ( hybrid) |
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Pfizer is seeking proposals for the advancement of RNA therapeutics and the development of the next generation of RNA medicines |
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Submissions invited for novel target concepts and therapeutic strategies amenable to RNA based approaches (mRNA, circular RNA, gene editing), in the following areas of interest:
- Cellular reprogramming:
- Cancer vaccines
- Infectious Disease Vaccines
- Chronic or Rare Kidney Disease (Focal Segmental Glomerulosclerosis, IgA Nephropathy, Alport Syndrome, or Autosomal Dominant Polycystic Kidney Disease)
- Rare Liver Diseases and Rare Neuromuscular Diseases
- Repeat Expansion Diseases (e.g. Huntington’s disease, Friedreich’s ataxia, ALS, myotonic dystrophy)
- Preference given to targets not amenable to small or large molecule intervention
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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RiPCA: An Assay for the Detection of RNA-Protein Interactions in Live Cells, Rosenblum, S. L., & Garner, A. L. (2022) Current Protocols, e358 (2). DOI: 10.1002/cpz1.358
Increasing interest in studying and modulating the interactions between RNAs and their RNA-binding proteins has indicated the need for enabling technologies. Existing means of detecting RNA-protein interactions (RPIs) are often limited to biochemical or post-lysis methods or cell-based methods that require the addition of an RNA-based affinity tag, such as the MS2 hairpin, precluding them from use in detecting small or highly processed RNAs. Taking advantage of bioorthogonal chemistry- and split-luciferase-based technologies, we developed an assay for the detection of RPIs in live cells. This article details the protocol and design considerations for RiPCA, or RNA interaction with Protein-mediated Complementation Assay.
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