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Calculating alternative interventions for cancer and infection with quantum physics concepts |
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A team co-led by Cleveland Clinic radiation oncologist Jacob Scott, MD, DPhil and Case Western Reserve University theoretical biophysicist Michael Hinczewski, PhD recently published findings from a new study that demonstrates, for the first time, how quantum physics concepts can assist in the development of novel drug interventions for cancer and bacterial infections. ( Iram, S., Dolson, E., Chiel, J., 2020, Nat Phys).
The team, which includes collaborators at the University of Maryland and the Institut Curie in Paris, has shown how ideas from quantum physics, such as principles of quantum control, can be translated and applied to biological problems. Their work developing a mathematical algorithm that can be used to design and speed-up specific interventions to prevent or overturn drug resistance opens the door for the potential of an entirely new area of study: quantum-inspired biological control.
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Powerful push to use AI for cancer immunotherapy |
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From The Daily: For artificial intelligence (AI) tools being developed at Case Western Reserve University to have impact in the fight against cancer, they’re going to have to be validated in rigorous human clinical trials.
That validation may be a step closer following two recent agreements among bioengineering pioneer Anant Madabhushi, PhD, a longtime collaborator at New York University, and select large pharmaceutical companies: |
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- In April, Madabhushi entered into a contract with AstraZeneca, a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of diseases in three therapy areas—oncology; cardiovascular, renal and metabolism; and respiratory and immunology.
- Earlier this year, Madabhushi inked a similar deal with United States-based Bristol-Myers Squibb Company, a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
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“This is an important step in not only validating our research, but in further advancing efforts to get the right treatment to the patients who will benefit the most,” said Madabhushi, the F. Alex Nason Professor II of Biomedical Engineering at Case Western Reserve and director of the Center for Computational Imaging and Personalized Diagnostics (CCIPD). “We have shown that our AI, our computational-imaging tools, can have the potential to predict an individual cancer patient’s response to immunotherapy.” Dr. Madabhushi is a member of the Case Comprehensive Cancer Center's Cancer Imaging Program and chair of the planning committee for the upcoming Artificial Intelligence in Oncology Symposium. |
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Immuno-Oncology Seminar Series returns for Fall 2020 |
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All members of the Case Comprehensive Cancer Center and Cleveland Clinic are invited to join us for the third round of the Immuno-Oncology Seminar Series in the fall of 2020, organized by the Center for Immunotherapy and Precision Immuno-Oncology. Each seminar will be held at 10 am ET. View the Fall 2020 seminar flyer.
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Wednesday, September 16
Memorial Sloan Kettering Cancer Center
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Thursday, October 29
Smilow Cancer Hospital
Yale Cancer Center
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Thursday, November 19
Abramson Cancer Center
University of Pennsylvania
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Thursday, December 3
Brigham and Women's Hospital
Dana-Farber Cancer Institute
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September 21-25 is National Postdoc Appreciation Week! |
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Since 2009, the National Postdoctoral Association (NPA) has sponsored National Postdoc Appreciation Day/Week to recognize the significant contributions that postdoctoral scholars make to U.S. research and discovery. This year, NPA is hosting a virtual, multi-institutional collaboration to celebrate National Postdoc Appreciation Week (NPAW) from September 21 to 25.
Events include a keynote with speakers, John Beacom, PhD and Christine Pfund, PhD, discussing best practices for mentorship and facilitated by the NPA; virtual networking; and, workshops hosted by the National Research Mentoring Network and The Postdoc Academy. |
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Do you have an awesome postdoc in your lab? Shout them out on Twitter between the 21st and 25th using #NPAW2020 and tagging us, @CaseCCC, so we can share, too! |
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VeloSano 7 Fundraising Continues through October 1 |
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To-date, the 44 members that comprise Team Case Comprehensive Cancer Center have raised $22,817 and counting for lifesaving cancer research at Cleveland's top-tier hospitals and research institutions.
Despite the shift to Virtual VeloSano, our team pressed on and remained committed to participating in their chosen activities - biking, hiking, walking and yes, even gardening. Fundraising for this year's event will continue through October 1, 2020. Thank you to our committed team members, those who have donated to the cause and all who have cheered them on!
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Case CCC COVID-19 Resource Hub |
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As the COVID-19 outbreak progresses, the Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.
To have a cancer-focused resource added to the page, please email cancer@case.edu. |
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Mon, Sept 14
Shared Resources Directors Meeting
12p Zoom
Pathology Student Seminar
Elizabeth Akinbiyi
Mears Lab
"Understanding how Post-translational Modifications Regulate the Mitochondrial Fission Machinery in Glioblastoma"
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Tues, Sept 15
MH Research-in-Progress and Seminar Series
Joshua Tobias, PhD
"Construction of mimotope-based vaccines for use in cancer immunotherapy"
SBIR/STTR Informational Webinar
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Weds, Sept 16
Immuno-oncology Seminar Series
Michael Postow, MD
Memorial Sloan Kettering Cancer Center
PRCHN Virtual Seminar Series
Erika Trapl, PhD
"The Equitable Impact of Cleveland's Tobacco 21 on Youth Access and the Use of Nicotine and Tobacco Products"
Biomedical Innovation and Entrepreneurship Club
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Thurs, Sept 17
Immunology Journal Club
Julie Zhou
Molecular Biology & Microbiology Seminar
Blessing Enya and Jacek Skowronski
"HIV Replication, DNA Repair Proteins, and HIV Vpr"
Prostate Cancer Working Group
Ian Mills
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Fri, Sept 18
Taussig Cancer Institute Grand Rounds
Sherwin Desouza, MD
8a via Teams
Cancer Center Seminar Series
Lorelei Mucci, MPH, ScD
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Mon, Sept 21
WRB Faculty Meeting with Stan Gerson
3p
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Tues, Sept 22
MH Research-in-Progress and Seminar Series
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Thurs, Sept 24
Immunology Journal Club
Carson Smith
Molecular Biology & Microbiology Seminar
Mary Ann Checkley Luttge and Benjamin Luttge
Karn Lab
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Fri, Sept 25
Taussig Cancer Institute Grand Rounds - CCF Only
M&M Conference
Sherwin Desouza, MD
8a via Teams
Cancer Center Seminar Series
Bill Nelson, MD, PhD
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Cancer Center Seminar Series
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Each Fall and Spring, the Case Comprehensive Cancer Center (Case CCC) hosts a weekly interdisciplinary seminar series addressing cutting-edge clinical, translational and basic research topics in cancer each Friday at 12 pm EST.
This series returns today, Friday, September 11 with Jennifer Cullen, PhD, MPH presenting, "History, Evolution, and Modern Opportunities in Cancer Population Sciences" on behalf of the Cancer Prevention, Control & Population Research Program. Dr. Cullen holds the The James T. Pardee - Carl A. Gerstacker Professorship in Cancer Research and is Associate Director for Cancer Population Sciences at the Case CCC.
Due to institutional health restrictions, the seminar will continue to be held available virtually via Zoom this semester. Attendees will be muted upon entry and are encouraged to submit questions via chat or audio when appropriate.
CME credit will still be available for those who attend seminars live via Zoom. Contact Kelsey Kirsch for more information. |
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VeloSano Trainee Dream Experiment Awardee Symposium Thursday, September 17, 2020, 9a via Zoom
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In 2019, the Case Comprehensive Cancer Center granted 8 trainees with VeloSano Trainee Dream Experiment Fellowships. Awardees will present their projects and outcomes to the cancer research community on Thursday September 17, 2020 at 9 am via Zoom.
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Cancer Center Seminar Series
Friday, September 18, 2020, 12p via Zoom
Our weekly seminar series will host its first external speaker, Lorelei Mucci, MPH, ScD on Friday, September 18. Dr. Mucci is professor of epidemiology at the Harvard T.H. Chan School of Public Health and leader of the Cancer Epidemiology Program at Dana-Farber/Harvard Cancer Center.
She will present, "IRONMAN: Findings and Future Directions in a Global Registry of Men with Advanced Prostate Cancer" on behalf of the Cancer Prevention, Control, & Population Research Program.
Dr. Mucci's major research focuses on the epidemiology of prostate cancer risk and progression within cohorts of men from the United States and Scandinavia, with an emphasis on biomarker studies, including circulating markers, inherited genetic susceptibility markers, as well as tumor biomarkers. Two of her specific areas of research are patho-epidemiology and twin studies of cancer.
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Registration Discount Extended: Artificial Intelligence in Oncology Virtual Symposium 2020
October 19-20, 2020
The second annual Artificial Intelligence in Oncology Symposium will bring together experts in AI and machine learning as well as clinical, industry and federal agency experts in pathology, radiology, drug discovery, and ethics and policy to speak on research developments, regulatory policy, reimbursement and ethics surrounding AI in oncology. For the health and safety of all attendees, this year's symposium will take place virtually.
Join us for four focused sessions, with international speakers and panel discussions providing unique perspectives on how AI and machine learning are impacting the major areas of radiology, pathology and -omics in the contexts of precision medicine approaches for characterizing tumors and predicting therapeutic response.
Beyond the science, attendees will be able to network and enjoy a special session highlighting some of the brightest rising stars in the field of AI in oncology, selected from abstract submissions. Submit your abstract by Friday, September 11!
Geraldine McGinty, MD, MBA, FACR will present the symposium plenary, "Fostering a Strong Ecosystem for AI in Medical Imaging." Dr. McGinty is an internationally recognized expert in imaging economics, Chair of the American College of Radiology Board of Chancellors and Chief Strategy and Contracting Officer at Weill Cornell Medicine in New York City.
Additional keynotes in drug discovery, ethics & policy and pathology will be delivered by Russ Altman, MD, PhD of Stanford University, Aashima Gupta, MS of Google, Vinay Prasad, MD, MPH of the University of California, San Francisco, and Yinyin Yuan, PhD of the Institute of Cancer Research, London. Learn more about AIO 2020 speakers.
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Case CCC Fall Clinical Research Retreat
October 28, 2020, 5-7p via Zoom
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The Case Comprehensive Cancer Center's Fall Clinical Research Retreat will be held virtually on October 28, 2020 from 5-7 pm.
The retreat theme is, "Immunotherapy in Cancer Research." The retreat will include a presentation by Leland Metheny, MD, Chair of the Case CCC Protocol Review and Monitoring Committee ( PRMC) and a keynote presentation from Timothy Chan, MD, PhD, Director of Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.
Registration is required.
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Biomedical Graduate Student Symposium (Virtual)
November 9-10, 2020
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The Biomedical Graduate Student Symposium (BGSS) is a student-run event that celebrates student research in the School of Medicine at CWRU. This event will consist of student poster presentations, student oral presentations, and a keynote address from Dr. Yasmine Belkaid, National Institute of Allergy and Infectious Diseases (NIAID). BGSS will also partner with the Career Opportunities for Trainees Series (COTS) for a career panel (details and panelists to be announced).
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Additional Upcoming Events |
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AACR Cancer Disparities Progress Report Virtual Congressional Briefing
September 16, 2020
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Please join the American Association for Cancer Research (AACR) on September 16, for a Virtual Congressional Briefing to unveil the inaugural AACR Cancer Disparities Progress Report 2020: Achieving the Bold Vision of Health Equity for Racial and Ethnic Minorities and Other Underserved Populations. The Report will undoubtedly increase public awareness and understanding of cancer health disparities and underscore the urgency of disparities research to saving more lives from this disease. It also emphasizes the vital need for continued transformative research and for increased collaboration among all stakeholders working toward the bold vision of health equity. |
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NCCN 2020 Virtual Congress: Hematologic Malignancies
October 9-10, 2020
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Attend this NCCN virtual congress to hear from world-renowned experts in the management of Hematologic Malignancies present the latest treatment advances, updates to the standard of care as recommended in the NCCN Guidelines®, and unique and challenging patient cases.
Co-chaired by Ranjana H. Advani, MD, Stanford Cancer Institute, and Andrew D. Zelenetz, MD, PhD, Memorial Sloan Kettering Cancer Center, this virtual program features presentations and interactive discussions highlighting the treatment options and supportive care for a variety of hematological malignancies.
This program is approved for AMA PRA Category 1 Credit™ for physicians and will award contact hours for nurses, pharmacists, and other health care professionals.
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NCCN 2021 Annual Conference: Call for Abstracts
Abstract Deadline: November 11, 2020
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NCCN is now accepting abstracts for consideration to be presented during the NCCN 2021 Annual Conference General Poster Session at the Rosen Shingle Creek in Orlando, Florida on Thursday, March 18 and Friday, March 19, 2021. NCCN welcomes original abstracts from investigators in the general oncology community. Submissions will be accepted from academic institutions, teaching and community hospitals, or industry. Both NCCN and non-NCCN institutions may participate.
Research may fall into the general areas below:
- Clinical Oncology (all phases)
- Pre-Clinical Oncology
- Epidemiology/Risks/Prevention
- Correlative/Genomic
- Best Practices in Implementation and Use of Clinical Practice Guidelines
- Quality Improvement
- Outcomes and Health Services Research
- Bioinformatics/Information Technology Sciences
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Sixth Computational Approaches for Cancer Workshop (CAFCW20)
Abstract Deadline: September 6, 2020
Workshop: November 13, 2020
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The National Cancer Institute Center for Biomedical Informatics and Information Technology and SC20 are seeking abstracts for presentations for the Sixth Computational Approaches for Cancer Workshop (CAFCW20). CAFCW20 is a workshop designed to bring together clinicians, cancer biologists, mathematicians, data scientists, computational scientists, engineers, developers, thought leaders, and anyone else interested in advancing computation to use in cancer care and research. This year’s topic is “AI and HPC: Overcoming Data Challenges in Cancer Research and Clinical Applications.”
A special emphasis for the CAFCW20 is the role of HPC and AI to address research challenges when data are limited by availability, variability and size. The workshop will be held in conjunction with SC20: The International Conference on High Performance Computing, Networking, Storage and Analysis in Atlanta, GA., on November 15.
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SGO 2021 Annual Meeting
Abstract Deadline: October 23, 2020
Annual Meeting: March 20-23, 2021
The Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer is a comprehensive forum for the subspecialty of gynecologic oncology. Whether you’re a physician, surgeon, researcher, allied health professional or a student in the field, you can join us to make the connections that will boost your career, see what’s new in gynecologic oncology science and research, and learn the best practices and techniques that can take your care to the next level.
The Call for Abstracts and Surgical Films for the SGO 2021 Annual Meeting on Women’s Cancer is open through October 23, 2020. Call for Late-breaking abstracts will be open December 1, 2020 through January 4, 2021.
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2020 Graft versus Host Disease Virtual Symposium
October 2, 2020
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The Meredith A. Cowden Foundation has hosted the GvHD National Symposium since 2010, focusing on cutting edge research and new treatments.
Due to COVID19 and the restrictions related to this pandemic, and the potential risks for symposium participants who may already be immunocompromised, the Foundation has decided to postpone the annual in-person meeting.
To address the continuing need to serve the community, the Foundation has decided to host a short ‘virtual’ symposium on Friday, October 2, 2020. This free, 2-hour event will consist of a clinical presentation by Dr. Dan Couriel from the University of Utah, followed by a patient-centered Q&A panel hosted by the GvHD planning committee.
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Internal LOI Deadline: September 15, 2020
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The Johnson & Johnson Scholars Program aims to fuel the development of female STEM2D leaders and feed the STEM2D talent pipeline by awarding and sponsoring women at critical points in their research careers, in each of the STEM2D disciplines: Science, Technology, Engineering, Math, Manufacturing, and Design.
The 3-year, $150,000 awards will fund one woman per discipline who has completed her advanced degree, who is working as an assistant professor and who is not yet tenured at an accredited university or design institution. The goal is to fuel the research passion of the awarded women and inspire career paths in their respective STEM2D fields.
By offering these awards, Johnson & Johnson hopes to play an influential role in STEM2D breakthroughs in the future. The award includes a J&J mentor and may include access to J&J tools.
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Internal Deadline: October 4, 2020
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The F99/K00 award is open to 3rd or 4th year PhD students, including F31 Fellowship applicants and current awardees (note that 3 rd or 4 th year students would have matriculated in 2017 or 2018). International students may also apply. Students Matriculated in a dual-degree program (e.g.) MD/PhD, DO/PhD, DDS/PhD, or DVM/PhD) are not eligible for the F99/K00 program. Projects must be clearly focused on cancer.
To apply for this award, an applicant must be nominated by their institution. As each institution is allocated only one nomination, the Case Comprehensive Cancer Center (Case CCC) requires potential applicants to assemble a pre-application.
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Deadline: October 14, 2020
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With the generous support from VeloSano Bike to Cure, the Case Comprehensive Cancer Center (Case CCC) is providing funding for Case CCC Trainee Associate Members to perform their “dream experiment.”
The experiment should catalyze highly innovative and impactful projects and help strengthen fellowship and career development grant applications. The intent of the award is to support a single or limited set of innovative experiments, not for general laboratory supplies/projects or maintenance of the trainee’s project.
Up to five (4) projects will be funded at $10,000/award. Research projects must be completed within one (1) year, with funds expended by June 30, 2021.
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Deadlines: October 21, 2020 (Young Investigator Eligibility Checklist) and November 4, 2020 (All Award Proposals)
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The Melanoma Research Alliance (MRA) is pleased to announce the Second Release of its Request for Proposals (RFP) for pre-clinical, translational, and early clinical research with the potential to produce unusually high impact, near-term advancements in melanoma prevention, detection, diagnosis, staging, and treatment.
The 2020 - 2021 award cycle, is anticipated to support at least $7.6 million in new funding. Proposals will be accepted for Established Investigator, Academic-Industry Partnership, Young Investigator, and Pilot Awards.
This Second Release includes two new Special Opportunity awards focused on Melanoma Brain Metastasis, in partnership with the Rising Tide Foundation for Clinical Cancer Research. Other Special Opportunities include:
- Pediatric Melanoma Young Investigator Award with St. Baldrick's Foundation
- UK or Israel-Based Young Investigator Award with Rosetrees Trust
- Radiation Oncology Young Investigator Award with ASTRO (US applicants only)
- Immunotherapy Young Investigator Awards supported by Bristol Myers Squibb (BMS)
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Pharmacy Times - August 24, 2020
Following the expansion of Medicaid coverage under the Affordable Care Act, individuals with low income are less likely to be diagnosed with advanced cancer, according to a team of investigators at the Case CCC in a study published in CANCER.
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Urology Times - September 9, 2020
“My thought, based on our work, is that it should be recommended for all healthy men to undergo some sort of PSA screening,” said study author Jonathan Shoag, MD, assistant professor of urology at Case Western Reserve University and member, Case CCC.
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Free Registration for the Fall 2020 NIH Virtual Seminar on Program Funding and Grants Administration |
Tuesday, October 27– Friday, October 30, 2020
No plane tickets, hotel costs, or food budgets to worry about! In fact, no registration fees either! The NIH is bringing the Fall 2020 NIH Virtual Seminar on Program Funding and Grants Administration direct to your computer…free of charge!
This event is designed to demystify the NIH grant application and review process. Be sure to check out all the networking opportunities taking place during the seminar. For instance, the Meet the Experts page highlights all of the NIH Institutes and Centers, offices and special programs offering booths filled with resources to fill your “swag bag” and times to chat with grants management, policy, review, and program officials throughout the seminar.
If you’re new to working with the NIH grants process as an investigator or administrator, this is a great way to connect and collaborate. Here’s what to expect:
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Four days of sessions with live and simu-live sessions, as well as an on-demand video library
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Three tracks designed around grants policies and programs, including case studies and Q&As
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Live chat opportunities with NIH & HHS experts on the grants process and policies
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Downloadable resources to reuse and/or share with others at your institution
- Free registration
See the latest registration and agenda updates on the seminar site. |
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Weekly NIH Funding Opportunities and Notices |
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COVID-19 Funding Opportunities and Notices |
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Use the button below to submit all your news, publications, events, announcements, lab openings and communications requests to the Case CCC Marketing and Communications team! We are here to help. |
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