The bottleneck that is the purification of oligos, peptides, mAbs and other therapeutics has been removed with YMC’s Contichrom continuous chromatography platform. Both bench jockeys and production people now have a proven means to significantly reduce time to market, resin cost and solvent / buffer consumption. Multiple GMP production sites have already employed YMC’s Contichrom systems to save million$ and accelerate product while reducing space – time for you to look into what multi-column technology can do for you.
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BioPharmGuy
Just finished the Walter Isaacson biography on Nobel-prize winner and CRISPR pioneer Jennifer Doudna. It was more like half biography, half overview on the whole CRISPR ecosystem/biotech history. Well-written and accessible even if you don't have a lot of in-depth life sciences experience. Check it out from your local library for $0, or buy it from Amazon for $21 .
Addition & Attrition
75 companies added, eight removed. Summary on the downloads page.
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Werewolf Therapeutics
Just after we hypothesized on a possible Beowulf Therapeutics last week, the real Werewolf Therapeutics filed for an IPO. They plan to use the ticker symbol HOWL. Oh snap, nicely done.
Pin Therapeutics
This company is working on protein degradation therapies. Their main product in development is targeting an aging-related disease and another, immunology. After that, things get interesting. The other three products are "Indication Agnostic". Wow, talk about aspirational - literal magic pills.
Moderna Presentation
If you have a day to to waste, maybe check out this 219-slide presentation from Moderna's Vaccines Day earlier in the week.
Elucid Bio
This company's website has a statement on the upper right area of the homepage which says "Website not compatible with Internet Explorer". Ok, well we're normal human beings, so we sure aren't using IE, but what happens when someone using IE visits the website? We checked - they see nothing but a bunch of black text on a white background telling them to download a real browser.
So that little statement on the homepage about Internet Explorer doesn't even show up when you're using Internet Explorer. How useful.
Tidal Therapeutics
Unhappy to admit it, but we had never heard of this company until this week. Not too surprising given they have no website, few employees, no prior news releases and have been operating for only 2+ years. Yet somehow in that time they managed to create $160M in value, because that's what Sanofi just paid for the business. (Plus another $310M in potential milestone payments.) Congrats to them and good luck to Sanofi. #notmymoney
Centrillion
The relaunch of their website has a countdown. Or rather, it had a countdown. It was to relaunch at midnight last night and since that didn't happen, it's now a countup.
Team Roast
We're all familiar with superstar entertainers going by one name - Madonna, Prince, Rihanna, the entire Brazilian national soccer team. But a biotech executive? That's a new one.
Repair Biotechnologies' CEO is known only as 'Reason' and has such qualifications as having founded a blog/news website that focuses on aging and having Masters degrees in Space Physics and Astrophysics. The perfect biotech CEO skillset - for heading to the moon!
It's not impossible for someone to have biotech knowledge without formal training, but if you're gonna take that leap and hire them as your CEO, maybe make sure they have a first and last name. Or at least something that sounds like a name, not the title of a libertarian magazine.
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Featured Company
YMC Process Technologies
YMC has a lot to offer. First off, if you're currently purifying peptides or oligos, they can help increase yield while also reducing solvent usage with their next-gen HPLC system. Not only that, as your process grows they have services to help you move from batch to continuous production. They're a big enough company to have the technology/know-how, but small enough to actually listen to customers. Check them out to see what they can do for your process.
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J&J Clot Nightmare
The CDC in the US has recommended a pause on usage of the J&J Covid vaccine due to rare blood clotting events (cerebral venous sinus thrombosis, CVST) in women aged 18-48. Roughly 7 million doses of vaccine have been administered to US adults, so a very rough estimate would be that maybe 500 thousand women in the 18-48 age range have received them.
Assuming half the CVST events went unreported, this would yield a 1 in 42,000 chance a woman receiving the J&J vaccine had this event. Though very rare, it may be prudent to move women 18-48 towards alternative vaccines until secondary factors are identified.
Unfortunately this rare side effect is going to scare many people from the J&J vaccine and provide fodder for social media demagogues to convince anyone who was already on the fence that all vaccines are bad. Terrible news for the world. Wise Uncle Derek goes into detail answering questions about this ordeal. Craig Spencer MD, briefly explains the upside on Twitter.
Chinese Vaccines
The director of China's CDC stated that Chinese Covid vaccines do not have very high efficacy. The communist party quickly instructed him to walk back his comments, which party propaganda outlets duly disseminated.
As a rule you should believe negative news and be skeptical of positive news out of a Chinese government official.
This reality is a big problem for China, but probably more so for the countries to which they have distributed vaccines. China can control Covid with draconian government measures, Argentina not so much.
The good news is the vaccines are almost certainly safe - it's very easy to get that info when you have a billion citizens. China still has a very low disease burden, so for now any research into newer vaccines will have almost no chance of completing domestic clinical trials. It's clearly still a good thing that China has few Covid cases. But what does it mean for next year? Who knows.
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Featured Job
Studylog - Software Trainer (Application Scientist) - East Coast / West Coast
Studylog is looking for a Software Trainer (Application Scientist) with a passion for animal research and training to instruct users of our world-class software. In this position you will represent the standards and quality of Studylog Systems, Inc. when training new users on Studylog software remotely and in labs and offices around the world. Join our small team making world-class software! Opening requires that you are familiar with Studylog's software.
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Go Big or Go Home
Back in 2006, the secret service seized fake $1 million bills that a church was using in a junk mail campaign. The ministry founder did not see how impersonating a $1 million bill could be a problem since they have never existed.
Cut to last week when two women in Tennessee received a similar bill in the mail and tried to buy "a few gift cards" at the Dollar Tree. Were they expecting $999,550 in ones as change? Unbelievable. Actually...totally believable.
One of the woman explained to police she was going to spend the gift cards on care packages for the homeless. If only there were a store nearby selling low-cost items, she could have skipped that annoying gift card step altogether.
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