Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal
Pengfei Ding, Siarhei Kharytonchyk, Alexis Waller, Ugonna Mbaekwe, SapnaBasappa, Nansen Kuo, Heather M. Frank, Christina Quasney, Aaron Kidane, Canessa Swanson, Verna Van,
Mitali Sarkar, Emily Cannistraci, RidhiChaudhary, Hana Flores, Alice Telesnitsky, Michael F. Summers. Proceedings of the National Academy of Sciences Jul 2020, 202008519;
Our findings suggest a sequential NC binding mechanism for Gag-genome assembly and identify a potential RNA Achilles’ heel to which HIV therapeutics may be targeted.