October 2019 We are excited to present the research community with the second edition of the Science Spotlight new sletter. It features publications from Brigham researchers in high-impact journals and funding updates from the prior month. In September there were: 19 papers led by Brigham researchers published in top-tier journals 4 research briefs 6 press releases 13 tweets about new research 106 awards and $99,096,603 awarded in new grants

Coapting Cost and Clinical Outcomes in Transcatheter Intervention for Secondary Mitral Regurgitation Bonow RO, Mark DB, O'Gara PT. Circulation . 2019 Sep 29. doi: 10.1161/CIRCULATIONAHA.119.043408.

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Metabolomic adaptations and correlates of survival to immune checkpoint blockade Li H, Bullock K, Gurjao C, Braun D, Shukla SA, [et al.] Giannakis M. Nat Commun. 2019 Sep 25;10(1):4346. doi: 10.1038/s41467-019-12361-9.

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Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Garo LP, Ajay AK, Fujiwara M, Beynon V, Kuhn C, [et al.] Murugaiyan G. Cell  Rep. 2019 Sep 24;28(13):3353-3366.e5. doi: 10.1016/j.celrep.2019.07.065 .

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From Focal Lipid Storage to Systemic Inflammation: JACC Review Topic of the Week. Libby P, Hansson GK. J Am Coll Cardiol. 2019 Sep 24;74(12):1594-1607. doi: 10.1016/j.jacc.2019.07.061.

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Li-Fraumeni syndrome presenting as precursor B lymphoblastic leukemia mimicking intravascular large B-cell lymphoma. Khatri SS, Kim AS. Blood . 2019 Sep 19;134(12):993. doi: 10.1182/blood.2019001407.

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Emapalumab for the treatment of relapsed/refractory hemophagocytic lymphohistiocytosis. Vallurupalli M, Berliner N. Blood . 2019 Sep 19. pii: blood.2019002289. doi: 10.1182/blood.2019002289.

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Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia. Lucena-Araujo AR, Coelho-Silva JL, Pereira-Martins DA, Silveira DR, Koury LC, [et al.] Rego EM. Blood . 2019 Sep 19;134(12):951-959. doi: 10.1182/blood.2019000239.

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Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials. Marston NA, Giugliano RP, Im K, Silverman MG, O'Donoghue ML, [et al.] Sabatine MS. Circulation . 2019 Sep 18. doi: 10.1161/CIRCULATIONAHA.119.041998.

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Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial. Bergmark BA, Bhatt DL, McGuire DK, Cahn A, Mosenzon O, [et al.] SAVOR-TIMI 53 Steering Committee and Investigators. Circulation . 2019 Sep 17;140(12):1004-1014. doi: 10.1161/CIRCULATIONAHA.119.040144.

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Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Kant S, Craige SM, Chen K, Reif MM, Learnard H, [et al.] Keaney JF Jr. Nat Commun. 2019 Sep 17;10(1):4223. doi: 10.1038/s41467-019-11982-4.

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White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study. Cetin-Karayumak S, Di Biase MA, Chunga N, Reid B, Somes N, [et al.] Kubicki M. Mol Psychiatry. 2019 Sep 11. doi: 10.1038/s41380-019-0509-y

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Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis. Aibana O, Huang CC, Aboud S, Arnedo-Pena A, Becerra MC, [et al.] Murray MB. PLoS Med. 2019 Sep 11;16(9):e1002907. doi: 10.1371/journal.pmed.1002907. eCollection 2019 Sep.

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Transcatheter Aortic Valve Replacement in Low-Risk Patients. Tang GHL, Verma S, Bhatt DL. Circulation . 2019 Sep 9;140(10):801-803. doi: 10.1161/CIRCULATIONAHA.119.041111.

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Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Circulation . 2019 Sep 9;140(10):846-863. doi: 10.1161/CIRCULATIONAHA.119.040563

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Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, [et al.] Shivdasani RA. Nat Med. 2019 Sep 9. doi: 10.1038/s41591-019-0573-5.

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ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis. Yang JS, Hsu JW, Park SY, Lee SY, Li J, [et al.] Hsu VW. Nat Commun. 2019 Sep 6;10(1):4068. doi: 10.1038/s41467-019-11932-0.

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Teamwork makes the dream work in thrombopoiesis. Asquith NL, Machlus KR. Blood . 2019 Sep 5;134(10):791-792. doi: 10.1182/ blood .2019002306.

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Fluorodeoxyglucose Uptake in Atheroma: Not So Simple. Libby P, Bhatt DL, Di Carli M. J Am Coll Cardiol. 2019 Sep 3;74(9):1233-1236. doi: 10.1016/j.jacc.2019.07.009.

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Are Phosphodiesterase-5 Inhibitors a New Frontier for Prevention of Colorectal Cancer? Jovani M, Chan AT. Gastroenterology . 2019 Sep;157(3):602-604. doi: 10.1053/j.gastro.2019.07.017. Epub 2019 Jul 13.

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