September 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and research metrics from the prior month. The gold colored buttons denote COVID-19 related publications.

In August there were: 40 papers led by Brigham researchers published in top-tier journals 42 tweets about new research 2 press releases 7 research briefs 56 awards with $32,984,967 in new grants

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Luoma AM, Suo S, Williams HL, Sharova T, Sullivan K, [et al.] Wucherpfennig KW. Cell. 2020 Aug 6;182(3):655-671.e22. doi: 10.1016/j.cell.2020.06.001. Epub 2020 Jun 29.PMID: 32603654

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Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease. Shan Z, Li Y, Baden MY, Bhupathiraju SN, Wang DD, [et al.] Hu FB. JAMA Intern Med. 2020 Aug 1;180(8):1090-1100. doi: 10.1001/jamainternmed.2020.2176.PMID: 32539102

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Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Jiang C, Lian X, Gao C, Sun X, Einkauf KB, [et al.] Yu XG. Nature. 2020 Sep;585(7824):261-267. doi: 10.1038/s41586-020-2651-8. Epub 2020 Aug 26.PMID: 32848246

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Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury. Renthal W, Tochitsky I, Yang L, Cheng YC, Li E, [et al.] Woolf CJ. Neuron. 2020 Aug 14:S0896-6273(20)30570-5. doi: 10.1016/j.neuron.2020.07.026. Online ahead of print.PMID: 32810432

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Astrocyte Crosstalk in CNS Inflammation. Linnerbauer M, Wheeler MA, Quintana FJ. Neuron. 2020 Aug 30:S0896-6273(20)30643-7. doi: 10.1016/j.neuron.2020.08.012. Online ahead of print.PMID: 32898475

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Assessment of Deaths From COVID-19 and From Seasonal Influenza. Faust JS, Del Rio C. JAMA Intern Med. 2020 Aug 1;180(8):1045-1046. doi: 10.1001/jamainternmed.2020.2306.PMID: 32407441

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Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology Yang HS, White CC, Klein HU, Yu L, Gaiteri C, [et al.] De Jager PL. Neuron. 2020 Aug 5;107(3):496-508.e6. doi: 10.1016/j.neuron.2020.05.010. Epub 2020 Jun 10.PMID: 32526197

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Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial. Okereke OI, Reynolds CF 3rd, Mischoulon D, Chang G, Vyas CM, [et al.] Manson JE. JAMA. 2020 Aug 4;324(5):471-480. doi: 10.1001/jama.2020.10224.PMID: 32749491

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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, [et al.] Tullius SG. Nat Commun. 2020 Aug 27;11(1):4289. doi: 10.1038/s41467-020-18039-x.PMID: 32855397

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Intracellular pH controls WNT downstream of glycolysis in amniote embryos. Oginuma M, Harima Y, Tarazona OA, Diaz-Cuadros M, Michaut A, [et al.] Pourquié O. Nature. 2020 Aug;584(7819):98-101. doi: 10.1038/s41586-020-2428-0. Epub 2020 Jun 24.PMID: 32581357

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Gastrointestinal synthetic epithelial linings. Li J, Wang T, Kirtane AR, Shi Y, Jones A, [et al.] Traverso G. Sci Transl Med. 2020 Aug 26;12(558):eabc0441. doi: 10.1126/scitranslmed.abc0441.PMID: 32848090

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APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival. Lee SH, Kang J, Ho A, Watanabe H, Bolshakov VY, Shen J. Neuron. 2020 Aug 27:S0896-6273(20)30642-5. doi: 10.1016/j.neuron.2020.08.011. Online ahead of print.PMID: 32891188

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Airborne Transmission of SARS-CoV-2: Theoretical Considerations and Available Evidence. Klompas M, Baker MA, Rhee C. JAMA. 2020 Aug 4;324(5):441-442. doi: 10.1001/jama.2020.12458.PMID: 32749495 No abstract available.

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Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB. Cell Metab. 2020 Aug 4;32(2):243-258.e6. doi: 10.1016/j.cmet.2020.05.017. Epub 2020 Jun 8.PMID: 32516575

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Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Lim D, Sreekanth V, Cox KJ, Law BK, Wagner BK, [et al.] Choudhary A. Nat Commun. 2020 Aug 13;11(1):4043. doi: 10.1038/s41467-020-17725-0.PMID: 32792475

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Microbial RNAs Pressure Piezo1 to Respond. Matute JD, Duan J, Blumberg RS. Cell. 2020 Aug 6;182(3):542-544. doi: 10.1016/j.cell.2020.07.015.PMID: 32763186

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Monogenic and polygenic inheritance become instruments for clonal selection. Loh PR, Genovese G, McCarroll SA. Nature. 2020 Aug;584(7819):136-141. doi: 10.1038/s41586-020-2430-6. Epub 2020 Jun 24.PMID: 32581363

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An Examination of Medical Malpractice Claims Involving Physician Trainees. Myers LC, Gartland RM, Skillings J, Heard L, Bittner EA, [et al.] Mort E. Acad Med. 2020 Aug;95(8):1215-1222. doi: 10.1097/ACM.0000000000003117.PMID: 31833853

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False Negative Tests for SARS-CoV-2 Infection - Challenges and Implications. Woloshin S, Patel N, Kesselheim AS. N Engl J Med. 2020 Aug 6;383(6):e38. doi: 10.1056/NEJMp2015897. Epub 2020 Jun 5.PMID: 32502334

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Sex, Gender, and Precision Medicine-Reply. Bartz D, Joffe H, Manson JE. JAMA Intern Med. 2020 Aug 1;180(8):1129-1130. doi: 10.1001/jamainternmed.2020.1620.PMID: 32511691 No abstract available.

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Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types. Khalsa JK, Cheng N, Keegan J, Chaudry A, Driver J, [et al.] Shah K. Nat Commun. 2020 Aug 6;11(1):3912. doi: 10.1038/s41467-020-17704-5.PMID: 32764562

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KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence. Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, [et al.] Simas JP. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22443-22451. doi: 10.1073/pnas.2004809117. Epub 2020 Aug 20.PMID: 32820070

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Assessment of Variation in State Regulation of Generic Drug and Interchangeable Biologic Substitutions. Sacks CA, Van de Wiele VL, Fulchino LA, Patel L, Kesselheim AS, Sarpatwari A. JAMA Intern Med. 2020 Aug 31. doi: 10.1001/jamainternmed.2020.3588. Online ahead of print.PMID: 32865564

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Effects of Interleukin-1β Inhibition on Incident Hip and Knee Replacement: Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial. Schieker M, Conaghan PG, Mindeholm L, Praestgaard J, Solomon DH, [et al.] Ridker PM. Ann Intern Med. 2020 Aug 4. doi: 10.7326/M20-0527. Online ahead of print.PMID: 32744862

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Disparities in United States hospitalizations for serious infections in patients with and without opioid use disorder: A nationwide observational study. Kim JH, Fine DR, Li L, Kimmel SD, Ngo LH, [et al.] Herzig SJ. PLoS Med. 2020 Aug 7;17(8):e1003247. doi: 10.1371/journal.pmed.1003247. eCollection 2020 Aug.PMID: 32764761

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Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae. Ma KC, Mortimer TD, Hicks AL, Wheeler NE, Sánchez-Busó L, [et al.] Grad YH. Nat Commun. 2020 Aug 17;11(1):4126. doi: 10.1038/s41467-020-17980-1.PMID: 32807804

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Global health and data-driven policies for emergency responses to infectious disease outbreaks. Kozlakidis Z, Abduljawad J, Al Khathaami AM, Schaper L, Stelling J. Lancet Glob Health. 2020 Aug 10:S2214-109X(20)30361-2. doi: 10.1016/S2214-109X(20)30361-2. Online ahead of print.PMID: 32791118

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Insurance Coverage after Job Loss - The Importance of the ACA during the Covid-Associated Recession. Agarwal SD, Sommers BD. N Engl J Med. 2020 Aug 19. doi: 10.1056/NEJMp2023312. Online ahead of print.PMID: 32813967

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The protein kinase Akt acts as a coat adaptor in endocytic recycling. Hsu JW, Bai M, Li K, Yang JS, Chu N, [et al.] Hsu VW. Nat Cell Biol. 2020 Aug;22(8):927-933. doi: 10.1038/s41556-020-0530-z. Epub 2020 Jun 15.PMID: 32541877

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Association Between Number of In-Person Health Care Visits and SARS-CoV-2 Infection in Obstetrical Patients. Reale SC, Fields KG, Lumbreras-Marquez MI, King CH, Burns SL, [et al.] Bateman BT. JAMA. 2020 Aug 14:e2015242. doi: 10.1001/jama.2020.15242. Online ahead of print.PMID: 32797148

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Human γδ T cells recognize CD1b by two distinct mechanisms. Reijneveld JF, Ocampo TA, Shahine A, Gully BS, Vantourout P, [et al.] Van Rhijn I. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22944-22952. doi: 10.1073/pnas.2010545117. Epub 2020 Aug 31.PMID: 32868441

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Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, [et al.] Quintana FJ. Nat Neurosci. 2020 Aug 10. doi: 10.1038/s41593-020-0700-0. Online ahead of print.PMID: 32778795

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Making the Call. Stuart JC. N Engl J Med. 2020 Aug 13;383(7):e46. doi: 10.1056/NEJMp2014108. Epub 2020 Jun 16.PMID: 32543794

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Seasonal Influenza Vaccination. Solomon DA. JAMA. 2020 Aug 14. doi: 10.1001/jama.2020.14772. Online ahead of print.PMID: 32797144

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Community Health Centers and Covid-19 - Time for Congress to Act. Kishore S, Hayden M. N Engl J Med. 2020 Aug 20;383(8):e54. doi: 10.1056/NEJMp2020576. Epub 2020 Jun 26.PMID: 32589372 No

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Influenza in the COVID-19 Era. Solomon DA, Sherman AC, Kanjilal S. JAMA. 2020 Aug 14. doi: 10.1001/jama.2020.14661. Online ahead of print.PMID: 32797145

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Using serological data to understand unobserved SARS-CoV-2 risk in health-care settings. Kucharski AJ, Nilles EJ. Lancet Infect Dis. 2020 Aug 3:S1473-3099(20)30579-X. doi: 10.1016/S1473-3099(20)30579-X. Online ahead of print.PMID: 32758436

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Challenges of "Return to Work" in an Ongoing Pandemic. Barnes M, Sax PE. N Engl J Med. 2020 Aug 20;383(8):779-786. doi: 10.1056/NEJMsr2019953. Epub 2020 Jun 18.PMID: 32558484

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Regulatory Decision-making on COVID-19 Vaccines During a Public Health Emergency. Avorn J, Kesselheim A. JAMA. 2020 Aug 31. doi: 10.1001/jama.2020.17101. Online ahead of print.PMID: 32870268

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From Icebox to Tinderbox - A View from the Southern Border. Cuneo CN, Janeway H. N Engl J Med. 2020 Aug 5. doi: 10.1056/NEJMp2009985. Online ahead of print.PMID: 32757518

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**Please visit the new MGB web page for COVID funding opportunities that provides a central database for researchers to view open and competitive funding announcements***

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