MAY 19, 2020


Publications

Recent high-impact publications from Rogel Cancer Center members.
A DEEPER LOOK INTO OUR RESEARCH
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Senior study author Jolanta Grembecka, Ph.D., left, with co-first author Hongzhi Miao, M.S. Photo by Leisa Thompson
“It’s extremely gratifying to see research we began here a decade ago, when I started at U-M as an assistant professor, taking tangible steps toward addressing this unmet medical need for leukemia patients,” - Jolanta Grambecka, Ph.D.

Drs. Pasca di Magliano, Bednar & Frankel. Photo by Leisa Thompson
In mouse models, the work uncovers a new potential target to improve immunotherapy approaches to the deadly disease.
BASIC SCIENCES
Publications from members of the Cancer Biology, Cancer Genetics, Cancer Hematopoiesis and Immunology and Developmental Therapeutics programs
McCool, K.; Freeman, Z. T.; Zhai, Y.; Wu, R.; Hu, K.; Liu, C. J.; Tomlins, S. A.; Fearon, E. R.; Magnuson, B.; Kuick, R.; Cho, K. R. Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts. Cancer Res (2020) 80:877-889. PMID: 31806642. PMCID: PMC7024672.

Ruan, S.; Lin, M.; Zhu, Y.; Lum, L.; Thakur, A.; Jin, R.; Shao, W.; Zhang, Y.; Hu, Y.; Huang, S.; Hurt, E. M.; Chang, A. E.; Wicha, M. S.; Li, Q. Integrin beta4-targeted cancer immunotherapies inhibit tumor growth and decrease metastasis. Cancer Res (2020) 80:771-783. PMID: 31843981. PMCID: PMC7024642.

Klossowski, S.; Miao, H.; Kempinska, K.; Wu, T.; Purohit, T.; Kim, E.; Linhares, B. M.; Chen, D.; Jih, G.; Perkey, E.; Huang, H.; He, M.; Wen, B.; Wang, Y.; Yu, K.; Lee, S. C.; Danet-Desnoyers, G.; Trotman, W.; Kandarpa, M.; Cotton, A.; Abdel-Wahab, O.; Lei, H.; Dou, Y.; Guzman, M.; Peterson, L.; Gruber, T. A.; Choi, S. M.; Sun, D.; Ren, P.; Li, L. S.; Liu, Y.; Burrows, F. J.; Maillard, I.; Cierpicki, T.; Grembecka, J. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest (2020) 130:981-997. PMID: 31855575. PMCID: PMC6994154.
Navaratna, T.; Atangcho, L.; Mahajan, M.; Subramanian, V.; Case, M.; Min, A.; Tresnak, D.; Thurber, G. M. Directed Evolution Using Stabilized Bacterial Peptide Display . J Am Chem Soc (2020) 142:1882-1894. PMID: 31880439.
Panwalkar, P.; Pratt, D.; Chung, C.; Dang, D.; Le, P.; Martinez, D.; Bayliss, J. M.; Smith, K. S.; Adam, M.; Potter, S.; Northcott, P.; Mascarenhas, L.; Shows, J.; Pawel, B.; Margol, A.; Huang, A.; Judkins, A. R.; Venneti, S. S WI/SNF complex heterogeneity relates with polyphenotypic differentiation, prognosis and immune response in rhabdoid tumors. Neuro Oncol (2020) In process. PMID: 31912158.

Qu, S.; Worlikar, T.; Felsted, A. E.; Ganguly, A.; Beems, M. V.; Hubbard, R.; Pepple, A. L.; Kevelin, A. A.; Garavaglia, H.; Dib, J.; Toma, M.; Huang, H.; Tsung, A.; Xu, Z.; Cho, C. S. Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy. J Immunother Cancer (2020) In process. PMID: 31940590. PMCID: PMC7057529.

Nessler, I.; Khera, E.; Vance, S.; Kopp, A.; Qiu, Q.; Keating, T. A.; Abu-Yousif, A. O.; Sandal, T.; Legg, J.; Thompson, L.; Goodwin, N.; Thurber, G. M. Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models. Cancer Res (2020) 80:1268-1278. PMID: 31941698. PMCID: PMC7073300.

Comba, A.; Dunn, P. J.; Argento, A. E.; Kadiyala, P.; Ventosa, M.; Patel, P.; Zamler, D. B.; Nunez, F. J.; Zhao, L.; Castro, M. G.; Lowenstein, P. R. FYN tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates anti-glioma immune responses. Neuro Oncol (2020) In process. PMID: 31950181.
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