A team of Animal Science faculty were recently awarded a $400,000 grant by the USDA National Institute of Food Agriculture to study the respiratory microbiome and metatranscriptome of beef cattle and their influences on bovine respiratory disease (BRD).
The four-year study, which focuses on what is widely considered the most common and costly disease facing beef producers, will have work conducted across multiple Arkansas Agriculture Experiment Stations in Batesville, Savoy and Hope. The group, consisting of Jiangchao Zhao, Beth Kegley, Jeremy Powell, Jung Ae Lee-Bartlett, John Richeson (West Texas A&M University) and Sarah Capik (Texas A&M AgriLife Research), looks to use the grant money to validate their study.
“This funding is very exciting and timely,” said Zhao. “It will allow our strong interdisciplinary team to investigate the correlations between the bovine respiratory microbiome and BRD with a longitudinal design and multi-location cross-validation.”
Through this research, Zhao and the group hope to validate their study and allow their findings to be used to help predict BRD in calves using the samples obtained from the nasal swabs. The results of these nasal samples could lead directly towards helping beef cattle producers save money and maintain a healthier stock overall. For example, a young calf whose nasal swab comes back clean would not need to be exposed to expensive BRD treatments. However, if a calf’s nasal swab is showing predictive signs of BRD, then it could be diagnosed and treated heavily at a very young age, thus greatly increasing its likelihood of growing up healthier.
“We hope to develop an accurate panel of nasal microbiome biomarkers that could be used to predict and diagnose the onset of BRD with a fast and non-invasive nasal swab sampling method,” said Zhao. “We would also better understand the pathobiology of BRD and hopefully identify some probiotics that could be used to prevent and/or treat BRD to reduce the cost and load of antibiotic treatment.”
This is a four-year project starting from August 1, 2019 to July 31, 2023, with two animal trials for two consecutive years (180 cattle each year). This large animal study with a longitudinal design, multi-location and multi-year cross-validation is expected to have a big impact on the beef cattle industry.
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