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William R. Huckle, Editor
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Boston, MA
Postponed until Summer 2021
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Vascular Biology 2020
An exciting virtual event
October 26-29, 2020
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Vascular Biology Publications Alert Now Available by Subscription
The NAVBO Vascular Biology Publications Alert will now be available to non-members for a $55 a year subscription. If you would like to receive this alert, but are not a member, please contact Danielle at membership@navbo.org.
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Shop at Amazon?
Help Support NAVBO
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Partner Network Advantage on the NAVBO Job Board
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Why post your job on NAVBO's career center rather than going directly to the larger job networks?
Pricing on the mass job boards can vary, but to get a job noticed you typically have to sponsor it for $5 - $10 per day, which can add up quickly especially since you also pay for each click the job gets. When you add it all together, you could be spending up to $45 per day on your job posting. But, when posting a job on NAVBO's career center, you simply pay a flat fee! The Premium package includes our Exclusive Extended Partner Network - which means the jobs are broadcast to sites like ZipRecruiter and Jobs2Careers and more for a flat fee.
With special member pricing, you can post a job for as low as $300 with this Partner Network. You never pay for each click, just the flat fee on the NAVBO career center. In addition, the Premium package includes a 60-day job posting making it a great value. The Premium packages also offer features like having your company's logo featured on the career center homepage, having your job appear first in search results, and more.
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Your data privacy and security are important to NAVBO. To that end, we have updated our privacy policy to reflect recent privacy and security regulation implementations and changes.
Please review our policy as time permits so you have a complete understanding of the data we have, why we have it, and how we use it.
Part of the updates relate directly to the European Union's new General Data Protection Regulation (GDPR) that went into place May 25. The GDPR seeks to improve the transparency of data usage and give end users more control over their own data. We believe these changes are important and will be compliant with the GDPR regulations.
Contact NAVBO if you have any questions or to
change your communication preferences.
Please note, you can unsubscribe to this newsletter at anytime by clicking on the SafeUnsubscribe in the footer.
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A special thank you to Srinivas Allanki (PhD Scholar, Stainier Lab, Max Planck Institute for Heart and Lung Research) for creating this fantastic logo for our online events!
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Seeking Nominations for NAVBO Awards
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Submit a Nomination for the NAVBO Meritorious Awards
The NAVBO Meritorious Awards Committee is currently seeking nominations for our two most prestigious awards - the
Earl P. Benditt Award which recognizes an individual who has made an outstanding discovery or developed a concept that has been seminal to our understanding of vascular biology or pathology; and the Judah Folkman Award in Vascular Biology, for an individual who is mid-
career (between 3 and 15 years of their first
faculty appointment) and has made a significant impact on the field of vascular biology through his/her original research accomplishments.
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Upcoming Webinars
Sara Nunes de Vasconcelos of the Toronto General Research Institute will present a webinar titled,
Therapeutic Vascularization for Tissue Regeneration on July 9 at 1:00pmET. Plan to join us!
Our August 13 webinar on
Lymphatic Development, will be very special! Organized by NAVBO Member, Kazuhide Okuda of the Peter MacCallum Cancer Centre, this session will feature Natasha Harvey of the University of South Australia and Jonathan Astin of the University of Auckland. The session will be held on Thursday evening at 8pm so that our colleagues in Asia and Australia can tune in live! Registration for this session will open soon.
Special Webinars on COVID-19
Here are the links to the recordings of our webinars on COVID-19:
The COVID-19 Pericyte Hypothesis (June 10)
Current Understanding of COVID-19 Pathology (May 8)
A special thank you to Ke Yuan of Boston Children's Hospital for organizing these sessions and the presenters: Christer Betsholtz, Uppsala University; Zorina Galis, NHLBI/NIH; Vinicio de Jesus Perez, Stanford University; and Bill Muller, Northwestern University.
Join us!! NAVBO Webinars are free to current NAVBO Members. Non-members can attend for $25 per webinar. Hint:
Join NAVBO!
And don't forget you can watch recorded webinars as well - go to
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Special Seminar at Northwestern
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This seminar is limited to 300 attendees, but the recording will be made available. The password is 2468 and the Meeting ID is 926 6194 0026. Click the flyer above for the link. Special thanks to Dr. Guillermo Oliver for bringing this to our attention and sharing it with the NAVBO Community.
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Register for the meeting
Submit Your Abstract
Very excited to be joined by:
The Microcirculatory Society
and the
American Society for Investigative Pathology
Plans are still underway for the program within this new format, but all speakers have agreed to participate, and the existing sessions will all take place! Tentative meeting dates are October 26-29, 2020.
Look for some exciting opportunities - Poster Discussions, Evening Discussions (perfect for our friends in Asia and Australia), Networking Discussions and more.
We recognize that you may not be able to register at this time, but please do submit an abstract! The deadline is August 3, 2020.
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Spotlight on Trainees - New NAVBO Program
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Emerging Scientists Series - Add Your Profile!! 
Take advantage of this opportunity to showcase your work for would be employers. Join Cody on our web site!
We have heard from a number of people that both graduation ceremonies and thesis presentations have been cancelled and/or reformatted for remote participation. Coupled with the temporary halt in in-person conferences, this situation may be making it more challenging for trainees to network, promote their science, and search for their next position. To address this, NAVBO will offer online opportunities for our trainee members.
The new Emerging Scientists Series will offer trainees the opportunity to showcase their thesis research in short research highlight talks. This new resource will serve as a place for trainees to share their work with employers that are hiring and searching for a new recruit with vascular biology research experience. Postdocs - looking for your first faculty position? You can use this service as well.
If you are a trainee that has just defended your thesis, or a postdoc seeking your first faculty position and are interested in this opportunity, please contact membership@navbo.org
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Call for Trainee Member Volunteers
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NAVBO Communications Committee is Seeking New Members!
   
Calling all Tweeters, Instagrammers, those that are LinkedIn and FaceBooking! Also, some web site savvy people!
If you are interested in being a part of this committee that focuses on NAVBO's communication to its members and the vascular biology community at large, please contact
info@navbo.org
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Development in Cardiovascular Disease - July 15 at 1:00pmET
Webinars included are:
Please review their recorded webinars prior to the live discussion on June 15
The session will be moderated by Nicholas Chavkin, University of Virginia
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June 22-July 1, 2020
 Did you miss the first two days of camp? No worries!
Join us for sessions on Bioengineering/Matrix Biology and Inflammation and gain access to the recordings on Development and Signaling. Students and other trainees should plan to join us!
Three-hour sessions will be held on Monday and Wednesday afternoons (1:00pm eastern time) and will include three lectures each, plus presentations by abstract authors.
Talks will be presented by:
*Masanoria Aikawa, Brigham and Women's Hospital
*Michelle Bendeck, University of Toronto
*Ondine Cleaver, UT Southwestern Medical Center
*Anne Eichmann, Yale University
Gabriele Fredman, Albany Medical College
Zorina Galis, NHLBI/NIH
*Courtney Griffin, Oklahoma Medical Research Foundation
Karen Hirschi, Yale School of Medicine
Lucy Liaw, Maine Medical College
*Bill Muller, Northwestern University
*Stefania Nicoli, Yale University
*Wayne Orr, LSU Health Science Center in Shreveport
Amber Stratman, Washington University in St. Louis
Mary Wallingford, Tufts Medical Center
Hiromi Yanagisawa, University of Tsukuba, Japan
*indicates organizers
Registration is free!! Hope you can join us!
Consider making a donation to NAVBO when you register
Important: If you are already registered for Summer Camp, check your email for important information. We are moving the sessions to a different webinar platform. We will be using GoToWebinar
(this is what we use for our monthly webinars and Journal Clubs)
. If you register anew, you will receive the correct links in your confirmation email. Follow the link above.
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Transitioning to the New Normal: Leaders' Lessons on Reopening Labs and Doing Science in a Pandemic
The COVID-19 pandemic forced research in most academic labs throughout the world to grind to a halt over the past three months. Now, as we emerge from quarantines and labs gradually reopen, PIs and trainees are learning to navigate largely uncharted paths of doing science in a pandemic. How do you hire a postdoc who cannot travel to your lab? As a trainee, how do you check out a lab that you can't visit? Without in-person conferences, what opportunities are there to network? How are labs re-opening safely? How do you train new students and staff when physical distancing is required? Can unspent grant funds be carried over?
Seven NAVBO Leaders -
Michelle Bendeck
(University of Toronto), Ondine Cleaver (UT Southwestern), Zorina Galis (NHLBI), William Huckle (Virginia Tech), Bill Muller (Northwestern University), Kristy Red-Horse (Stanford University) and Linda Shapiro (University of Connecticut)
- recently participated in an online discussion to share their experiences and advice on these topics and more. From virtual lab tours to training via Facetime to resources for online networking (including the NAVBO Emerging Scientist Series and NAVBO Happy Hours*), their Leaders' Lessons on transitioning to the new normal can be watched here.
* Happy Hours are Friday's at 5:00pm ET (no happy hour on June 26 or July 3)
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Welcome to our New Members:
Daniel Castranova,
NICHD/NIH
Xiaowen Chen,
University of Pennsylvania
Sandro Da Mesquita, University of Virginia
Colin Evans, Northwestern University
Dymonn Johnson, Washington University School of Medicine
Maziar Rahmani, National Institutes of Health
Bakary Samasa,
NICHD/NIH
Camilla Ferreira Wenceslau, The University of Toledo College of Medicine
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| Recent Publicatons by NAVBO Members |
Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage Using iDISCO+ and Light Sheet Fluorescence Microscopy
Journal of Visualized Experiments
The lymphatic system associated with the central nervous system (CNS) includes the lymphatic vasculature that spins around the brain, the spinal cord, and its associated LNs. The CNS-associated lymphatic system is involved in the drainage of CSF macromolecules and meningeal immune cells toward CNS-draining LNs, thereby regulating waste clearance and immune surveillance within CNS tissues. Read more
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Platelet factor 4 is a biomarker for lymphatic-promoted disorders
Journal of Clinical Investigation Insight
Genetic or acquired defects of the lymphatic vasculature often result in disfiguring, disabling and, occasionally, life-threatening clinical consequences. Advanced forms of lymphedema are readily diagnosed clinically, but more subtle presentations often require invasive imaging or other technologies for a conclusive diagnosis. Read more
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Altered Lipid Domains Facilitate Enhanced Pulmonary Vasoconstriction after Chronic Hypoxia
American Journal of Respiratory Cell and Molecular Biology
Chronic hypoxia (CH) augments depolarization-induced pulmonary vasoconstriction through superoxide-dependent, Rho kinase-mediated Ca2+ sensitization. Nicotinamide adenine dinucleotide phosphate oxidase and EGFR (epidermal growth factor receptor) signaling contributes to this response. Read more
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Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling
American Journal of Respiratory Cell and Molecular Biology
Pulmonary vasoconstriction resulting from intermittent hypoxia (IH) contributes to pulmonary hypertension (pHTN) in patients with sleep apnea (SA), although the mechanisms involved remain poorly understood. Read more
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Hepatic Vein Blood Increases Lung Microvascular Angiogenesis and Endothelial Cell Survival-Toward an Understanding of Univentricular Circulation
Seminars in Thoracic and Cardiovascular Surgery
To improve our understanding of pulmonary arteriovenous malformations in univentricular congenital heart disease, our objective was to identify the effects of hepatic vein and superior vena cava constituents on lung microvascular endothelial cells independent of blood flow. Read more
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CSR seeks to advance racial equity in grant application review
In her
June 12 "Review Matters" column, Noni Byrnes, Director of the Center for Scientific Review at the NIH, addresses racial disparities in NIH R01 award rates between White and Black applicants. While acknowledging that many secondary variables confound isolating the effect of race in the peer review process, Dr. Byrnes forcefully argues that "...implicit bias exists in all of us as individuals, and the CSR peer review process, with 18,000 unique individuals serving as reviewers, is not immune from these biases." She describes initiatives the CSR intended to mitigate bias and thus better fulfill the Center's mission of providing a review process that is fair, independent, and free from inappropriate influences.
Evidence grows for prominent role for the vasculature dysfunction in COVID-19
Inspired in part by a
recent review
from NAVBO member Peter Carmeliet and his Belgian and Chinese colleagues implicating damage to the endothelium as an essential contributor to the initiation and propagation of severe COVID-19 disease, attention has become more sharply focused on the vasculature as a trigger for the coronavirus's
life-threatening 'second phase.'
Other
research published in the NEJM
notes a marked increase in the prevalence of alveolar capillary microthrombi and intussusceptive angiogenesis detected at autopsy in patients with COVID-19 compared to those with influenza. Vessels leakage and microthrombi formation in turn spark inflammation throughout the body and fuel the acute respiratory distress syndrome associated with most COVID-19 patient deaths.
Seeking the new normal (for now) in conducting basic research
Chemical & Engineering News
has interviewed researchers and safety experts about their efforts to ensure workers' health and safety as the broad research community moves, with due deliberation, to
resume activities after closures
and quarantines.
While universities and public and private research institutes are keen to get back to work at full speed, what lab work will look like going forward remains to be seen. Pharmaceutical businesses were designated as essential under Department of Homeland Security guidelines and could remain operating, albeit under tightened safety protocols. However, most academic and government labs closed, except for work related to SARS-CoV2 and its associated COVID-19 illness.
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Frontiers in Cardiovascular Medicine
Special Research Topics
Putting Engineering Back In Vascular Tissue Engineering To Advance Basic Science and Clinical Applications
Topic Editors: Jessica Wagenseil (Washington University in St. Louis) and W. Lee Murfee (University of Florida).
This topic is sponsored by NAVBO
Vascular tissue engineering (VTE) can be characterized as the creation of replacement vessels. Over the past 30 years, approaches have incorporated different combinations of extracellular matrix scaffolds, cells and biological active chemical cues. Challenged by the goal to recapitulate the complexity of big or small vessels, the clinical use of in vitro tissue engineered vessel replacements is still limited. With research more often focusing on reductionist materials science or cell biology characterization of vessel-like constructs, an opportunity has emerged to re-apply engineering approaches to guide the next step in VTE.
Submit your manuscript by October 17, 2020
What do we know about COVID-19 implications for cardiovascular disease?
The coronavirus epidemic causes major cardiovascular complications. Underlying mechanisms, however, remain incompletely understood. Frontiers in Cardiovascular Medicine invite you to submit your article on this topic. We consider all types of manuscripts: fundamental basic science reports, translational or clinical studies, review articles and methodology papers.
Submit your manuscript by August 28, 2020
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This month we are highlighting the lab of Dr. Marlene Rabinovitch, who is a Professor at the Stanford University School of Medicine. Find out more about Dr. Rabinovitch's lab at
