HIRN 2020
Annual Investigator Meeting
To ensure the success of the HIRN Annual Investigator Meeting
,
we have made the decision to
host
a virtual meeting
this fall given the uncertainties stemming from the COVID epidemic
. We are actively working on modifying the meeting logistics
, and
wanted to share the following preliminary information with you, as we recognize this may impact travel plans and scheduling:
Dates
: Wednesday September 30
th
through Friday October 2
nd
with online activity limited to 4-5 hours per day.
Abstracts
: Deadline has been
extended
to
Friday, July 10
th
. Abstracts must be submitted via the
submission link
Presentations
: We will follow a format similar to the American Diabetes Association (ADA) with pre-record presentations in advance of release during the meeting.
Consortium Meetings
: The consortium meetings will not occur in parallel with the Investigator Meeting. Please contact the
HIREC
if you have any questions.
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HIRN Emerging Leaders in T1D
"HIRN Emerging Leaders in T1D” is a new competitive announcement to provide support and protected time for senior postdoctoral fellows seeking to pursue studies that will enhance their transition toward independent research careers. This opportunity is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial that is itself comprised of a clinical trial intervention.
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Save the Date!
Promoting the resources developed in HIRN is an important way to interact with the scientific community and ensure that precious investments are fully leveraged. A new webinar series has been created, open to the public, for those within or outside of HIRN to learn more about the reagents,
datasets, technologies, pipelines,
and protocols within this Network. Please save the data for our inaugural webinar on the development and use of Adeno-Associated Virus (AAV) vectors scheduled for July 24, 2020 at 11:00 PST. Additional meeting information coming soon.
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Resource Browser Release (Version 2.93)
The
HIRN Resource Browser
now has over one thousand entries! We are committed to making sure your resources are discoverable by others in the diabetes research community and beyond. The latest version (version 2.9.3) has an emphasis on enabling interoperability with user-defined computational workflows. Furthermore, the user interface has been revamped to streamline presentation of data and provide insightful usage/impression metrics. Helpful guides have also been added to describe the data input and output procedures. If you have resources not currently registered in the Resource Browser, let us know at
,
contact us
and we can provide assistance in loading your data.
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As many of you are aware, islet distributions from the Integrated Islet Distribution Program (IIDP) and other major islet distributors were paused in March due to concerns over the COVID-19 pandemic. As of June 2020, the IIDP has authorized its islet production centers to resume islet isolations for pancreata obtained from donors that were tested and confirmed as negative for COVID-19. Islet distributions will resume shortly, and we expect to return to full production levels by July unless the COVID-19 pandemic causes new laboratory closures.
The Alberta Diabetes IsletCore officially re-opened on May 25 following approval from our Institution, completion of COVID-19-specific staff training, and implementation of strict safety measures. All pancreas donors within Canada are screened and tested for COVID-19. Our human islet isolation program will only be accepting donors with: No travel in the last 14 days; No known COVID-19 exposure in the last 14 days; and Negative COVID-19 test results in 2 independent samples. Please don't hesitate to contact either Dr. Jocelyn Manning Fox or Dr. Patrick MacDonald if you have any questions, or if you would like to obtain any samples from our biobank.
Remarkable, one of HIRN’s partner programs, nPOD, remained open during the COVID-19 pandemic. Indeed, in its 14 years of operations, despite hurricanes, flooding, and now COVID-19, nPOD has never totally suspended its operations in terms of case recoveries from organ donors. As a result of this, nPOD was able to recover a series of new cases that should be of interest to the diabetes research community, including those within the HIRN. Importantly, nPOD is currently in the process of testing for COVID-19 on all organ donor cases received since October 2019 to ensure all samples are safe for investigator distribution.
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IIDP Islet Award Initiative
The
Integrated Islet Distribution Program (IIDP)
is now accepting applications for the August 1
st
, 2020 due date for the Islet Award Initiative (IAI) submissions. This initiative, generously supported by JDRF, will provide investigators new to the human islet field with up to 100,000 IEQs without the need for a subscription fee. We are excited to announce that we expect to be able to fund 5-6 awards this cycle. Interested investigators should visit the
IIDP website
for more details about the program, application instructions, and eligibility criteria or contact the
IIDP
directly by email at with any questions.
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American Diabetes Association
COVID-19 and Diabetes Research Award
PAR-20-140
Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
- Application due date: Standard dates apply
- Foreign applications are allowed
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NIH Requests for Applications (RFAs)
PAR-20-140
Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
- Application due date: Standard dates apply
- Foreign applications are allowed
RFA-DK-19-026
New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)
- Application due date: November 3, 2020
- Foreign applications not allowed
RFA-DK-19-027
Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)
- Application due date: October 3, 2020
- Foreign applications not allowed
F31 PAR-19-378
: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
- Application due date: Standard dates apply
- Foreign applications allowed
F32 PAR-19-379
: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
- Application due date: Standard dates apply
- Foreign applications allowed
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Program Director for Diabetes Epidemiology
If you are an epidemiologist with diabetes or diabetes relevant research experience and are seeking an exciting career opportunity, we may be the right place for you. The Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH has a position available for a program director (Health Science Administrator) for diabetes epidemiology research. Applicants must be U.S. Citizens.
Program Director for Diabetes Behavioral Science
If you are a clinical health psychologist with diabetes or diabetes relevant clinical/behavioral research experience and are seeking an exciting career opportunity, we may be the right place for you. The Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH has a position available for a for a program director (Health Science Administrator) for diabetes behavioral research. Applicants must be U.S. Citizens.
Physician to Oversee Diabetes Clinical Studies
If you are a physician scientist with the knowledge and insight to identify important scientific opportunities and to participate in the design and oversight of multi-center and single center clinical trials or observational diabetes studies and are seeking an exciting career opportunity, we may be the right place for you. The Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH has a position available for a Physician with expertise in diabetes and clinical research. Applicants must be U.S. Citizens.
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New Job Openings in Research & Academia
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We are seeking a highly motivated individual for a postdoctoral position in the Department of Pathology at the Children’s Hospital of Philadelphia. Our laboratory focuses on using human embryonic stem cell and iPS cell models to study human pancreatic development and diabetes. The NIH funded position aims to use the human ES/iPS system to study monogenic forms of diabetes using genome engineered stem cell lines. Applicants must have a PhD or MD degree in the biological or physical sciences. Prior laboratory experience in cell culture, basic molecular biology, and flow cytometry is preferred. The position is available Fall of 2020, with some flexibility for a later start date.
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Postdoctoral Associate
The Department of Microbiology and Immunology at the University of Miami, Miller School of Medicine is seeking a highly motivated, ambitious, creative, and dynamic postdoctoral research fellow to join Dr. Serafini’s, NIH-funded, translational group for projects in immunology, targets discovery, and in vivo targeted delivery of therapeutics and imaging reagents.
Ph.D. or other doctoral degree in molecular biology, endocrinology, immunology, or similar fields or M.D. Prefer proven experience in molecular biology and RNA. Good knowledge of aptamer technology and beta cell biology.
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Postdoctoral positions in the Kulkarni Lab at
Joslin Diabetes Center, Harvard Medical School
. Applications are invited for prospective Post-Doctoral Fellows to train in the Kulkarni Lab. The position is available immediately for a period of 2 years with the possibility of extending for a third year based on available funds and performance of the Fellow. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in exciting projects focused on defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis. Successful candidates should have a strong background in molecular biology, cell biology and biochemistry. It is strongly preferable to have prior experience in bioinformatics and the ability to interrogate “omics” and sequencing datasets. Prospective candidates should possess skills in handling human islets and undertake animal studies. It would be an advantage to be able to undertake rodent islet isolation, and perform immunostaining.
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Current Job Openings in Research & Academia
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Faculty Position
The
Lilly Diabetes Center of Excellence (LDCE)
at the Indiana Biosciences Research Institute (IBRI) is recruiting promising young investigators to start their own independent laboratories under excellent research conditions. The LDCE is recruiting high-potential Principal Investigators (PIs) at the IBRI in Indianapolis, Ind., who are interested in pancreatic beta cell research, particularly related to iPSC-derived beta cells and the crosstalk between beta cells and the immune system in type 1 diabetes (T1D).
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Faculty Position
The Department of Pathology, Immunology and Laboratory Medicine,
University of Florida Diabetes Institute
is seeking creative and highly motivated individuals for the position of Postdoctoral Associate under the direction of Dr. Todd Brusko. The Postdoc will be engaged in studying novel pathways regulating the differentiation and pathogenicity of T cells, the function of regulatory T cell biology in autoimmunity.
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Faculty Position
The
Diabetes Center of Excellence at the University of Massachusetts Medical School
invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment.
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Faculty Position
The Diabetes Clinical Research Program (DCRP) at
Benaroya Research Institute
seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement.
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The
University of Miami Miller School of Medicine
Department of of Microbiology and Immunology is accepting applications for Assistant and Associate Professor level for investigators with research interests related to immunotherapy of cancer, autoimmunity, or infectious diseases. Applicants should have a Ph.D., M.D. or equivalent, at least 3 years of postdoctoral training.
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Postdoctoral Position
The
laboratory
of Dr. Seung Kim at the Stanford University School of Medicine and the Stanford Diabetes Research Center has an immediate opening for a post-doctoral fellow to work on one or more projects involving organ regeneration and development, stem cells, and diseases like diabetes mellitus. Applicants with skills or interest in developmental biology, cell and stem cell biology, immunology, genetics, physiology and/or bioinformatics are especially encouraged to apply. Previous experience working with mice, mammalian cell culture, statistical and computational methods for analyzing genome-scale data sets or large imaging files is an asset, but not required.
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Postdoctoral Position
Two postdoctoral fellow positions at the Indiana Biosciences Research Institute are available in the IBRI Diabetes Center. We are looking for highly motivated researchers to join the IBRI in the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens.
The selected candidate will participate in a team working with primary human and rodent islets, animal models of diabetes and human beta cell lines, and advanced molecular biology techniques. A strong understanding of beta cell biology and/or molecular biology is important. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the lab.
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project " U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, " where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies.
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Postdoctoral Position
We are looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging.
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Postdoctoral position in the Lab of Dr. Sangeeta Dhawan at the
Beckman Research Institute
at
City of Hope
, in Los Angeles county, CA to study the epigenetic regulation of pancreatic beta cell mass. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable.
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Postdoctoral position in the Lab of Dr. Doris Stoffers in the
Institute for Diabetes, Obesity, and Metabolism
within the
Perelman School of Medicine
at the
University of Pennsylvania
. A PhD is required; experience in genetic mouse models, islet physiology, advanced molecular techniques, high throughput sequencing methodologies and bioinformatics, proteomics, metabolomics is helpful.
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Postdoctoral Position
The
Lab of Dr. Abdelfattah El Ouaamari
at
Rutgers University/Robert Wood Johnson Medical School
is recruiting self-driven, creative and organized candidates with a PhD in neuroscience, biochemistry or molecular and cellular biology. The candidate must possess skills in manipulating and assessing neuronal activity.
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Laboratory Assistant
One Laboratory Assistant position at the Indiana Biosciences Research Institute is available in the IBRI Diabetes Center. We are looking for highly motivated laboratory assistant to join the IBRI in the iPSC Core Facility coordinated by Dr. Decio Eizirik. This Core aims to differentiate pancreatic beta cells and other cell types departing from iPSC cells. The selected candidate will participate in a team working with iPSC derived beta cells, functional studies and advanced molecular biology techniques. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the iPSC Core.
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