A team of Salk Institute researchers led by President
Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment. The all-star interdisciplinary team will investigate mechanisms underlying Alzheimer's disease and aging-related cognitive decline and uncover new therapies. This bold venture will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics.
The lab of Professor
Reuben Shaw showed that late-stage cancers can trigger the enzyme AMPK's cellular recycling signal to cannibalize pieces of the cell, supplying large lung tumors with the nutrients they need to grow. The work, which appeared in
Cell Metabolism, suggests that blocking AMPK in some conditions could stop the growth of advanced tumors in the most common type of lung cancer.
Researchers report new methods to identify Alzheimer's drug candidates that have anti-aging properties
Old age is the greatest risk factor for many diseases, including Alzheimer's disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. Professor
Dave Schubert,
Salk Senior Staff Scientist Pamela Maherand colleagues have identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice. The work was published in
Trends in Pharmacological Sciences.
Clodagh O'Shea receives Allen Distinguished Investigator award to study genome
Professor
Clodagh O'Shea, a Howard Hughes Medical Institute Faculty Scholar, has been selected as a recipient of The Paul G. Allen Frontiers Group's Allen Distinguished Investigator (ADI) program. She will be awarded $1.5 million over three years to conduct research into how DNA and its associated proteins (known collectively as chromatin) are packaged in the nucleus of cells.
Salk mourns the passing of
Salk Professor Melvin Cohn, titan of immune system biology and a pioneering researcher in the field of gene regulation. Cohn passed away on October 23, 2018, in San Diego, California, at the age of 96.
Terrance Sejnowski talks about his new book
on the "How to Start a Deep Learning Revolution" episode of the podcast Brain Inspired. Listen to podcast »
Satchin Panda's recent research on time-restricted diets is featured in a Q&A with India'sScroll.In Read article »
The sixth season of the Salk Science & Music Series continues at 4:00 p.m. on Sunday, December 9, 2018, with a performance by
world-renowned pianist
Alessio Bax along with a short scientific talk by Salk Assistant Professor
Graham McVicker. Enjoy a musical program from Marcello, Rachmaninoff, Dallapiccola and Liszt. Be amazed and inspired!
The 2018
Salk Cancer Center team featured 45 riders/walkers/runners and volunteers who joined together in support of leading-edge cancer research
--- more than than 3,000 people participated overall.
Pedal the Cause awards research grants to cross-institutional teams of physicians and scientists from San Diego's top cancer institutions. It is one of the largest stand-alone cancer fundraising events in San Diego. Donations will be accepted until December 9.
