August 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and research metrics from the prior month. The gold colored buttons denote COVID-19 related publications.

In July there were: 56 papers led by Brigham researchers published in top-tier journals 35 tweets about new research 8 press releases 2 research briefs 92 awards with $100,976,525 in new grants

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, [et al.] Jonigk D. N Engl J Med. 2020 Jul 9;383(2):120-128. doi: 10.1056/NEJMoa2015432. Epub 2020 May 21.PMID: 32437596

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Coffee, Caffeine, and Health. van Dam RM, Hu FB, Willett WC. N Engl J Med. 2020 Jul 23;383(4):369-378. doi: 10.1056/NEJMra1816604.PMID: 32706535 Review.

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Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. Gupta S, Hayek SS, Wang W, Chan L, Mathews KS, [et al.] Leaf DE; STOP-COVID Investigators. JAMA Intern Med. 2020 Jul 15:e203596. doi: 10.1001/jamainternmed.2020.3596. Online ahead of print.PMID: 32667668

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Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers. Wang X, Ferro EG, Zhou G, Hashimoto D, Bhatt DL. JAMA. 2020 Jul 14:e2012897. doi: 10.1001/jama.2020.12897. Online ahead of print.PMID: 32663246

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The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study. Brown JM, Siddiqui M, Calhoun DA, Carey RM, Hopkins PN, Williams GH, Vaidya A. Ann Intern Med. 2020 Jul 7;173(1):10-20. doi: 10.7326/M20-0065. Epub 2020 May 26.PMID: 32449886

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Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older. Orkaby AR, Driver JA, Ho YL, Lu B, Costa L, [et al.] Djousse L. JAMA. 2020 Jul 7;324(1):68-78. doi: 10.1001/jama.2020.7848.PMID: 32633800

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Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Vaduganathan M, Claggett BL, Jhund PS, Cunningham JW, Pedro Ferreira J, [et al.] McMurray JJV, Solomon SD. Lancet. 2020 Jul 11;396(10244):121-128. doi: 10.1016/S0140-6736(20)30748-0. Epub 2020 May 21.PMID: 32446323 Clinical Trial.

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A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, [et a.] Peduzzi P; STRIDE Trial Investigators. N Engl J Med. 2020 Jul 9;383(2):129-140. doi: 10.1056/NEJMoa2002183.PMID: 32640131 Clinical Trial.

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Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, [et al.] Kamatani Y. Nat Genet. 2020 Jul;52(7):669-679. doi: 10.1038/s41588-020-0640-3. Epub 2020 Jun 8.PMID: 32514122

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Women's Representation Among Members and Leaders of National Medical Specialty Societies. Jagsi R, Means O, Lautenberger D, Jones RD, Griffith KA, [et al.] Chatterjee A. Acad Med. 2020 Jul;95(7):1043-1049. doi: 10.1097/ACM.0000000000003038.PMID: 31625994

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RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares. Orange DE, Yao V, Sawicka K, Fak J, Frank MO, [et al.] Darnell RB. N Engl J Med. 2020 Jul 16;383(3):218-228. doi: 10.1056/NEJMoa2004114.PMID: 32668112

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Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications. Tarazona OA, Pourquié O. Dev Cell. 2020 Jul 20;54(2):282-292. doi: 10.1016/j.devcel.2020.06.035.PMID: 32693060 Review.

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Airborne Transmission of SARS-CoV-2: Theoretical Considerations and Available Evidence. Klompas M, Baker MA, Rhee C. JAMA. 2020 Jul 13. doi: 10.1001/jama.2020.12458. Online ahead of print.PMID: 32658248 No abstract available.

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Relationships as the Backbone of Feedback: Exploring Preceptor and Resident Perceptions of Their Behaviors During Feedback Conversations. Ramani S, Könings KD, Ginsburg S, van der Vleuten CPM. Acad Med. 2020 Jul;95(7):1073-1081. doi: 10.1097/ACM.0000000000002971.PMID: 31464736

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Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona. Blume JE, Manning WC, Troiano G, Hornburg D, Figa M, [et al.] Farokhzad OC. Nat Commun. 2020 Jul 22;11(1):3662. doi: 10.1038/s41467-020-17033-7.PMID: 32699280

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An ecological framework to understand the efficacy of fecal microbiota transplantation. Xiao Y, Angulo MT, Lao S, Weiss ST, Liu YY. Nat Commun. 2020 Jul 3;11(1):3329. doi: 10.1038/s41467-020-17180-x.PMID: 32620839

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A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. Guo Y, Rist PM, Daghlas I, Giulianini F; International Headache Genetics Consortium; 23andMe Research Team, Kurth T, Chasman DI. Nat Commun. 2020 Jul 6;11(1):3368. doi: 10.1038/s41467-020-17002-0.PMID: 32632093

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AHR is a Zika virus host factor and a candidate target for antiviral therapy. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, [et al.] Quintana FJ. Nat Neurosci. 2020 Aug;23(8):939-951. doi: 10.1038/s41593-020-0664-0. Epub 2020 Jul 20.PMID: 32690969

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Blame. Gay E. N Engl J Med. 2020 Jul 2;383(1):9. doi: 10.1056/NEJMp2000393.PMID: 32609978

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Diagnosing and Treating Systemic Racism. Evans MK, Rosenbaum L, Malina D, Morrissey S, Rubin EJ. N Engl J Med. 2020 Jul 16;383(3):274-276. doi: 10.1056/NEJMe2021693. Epub 2020 Jun 10.PMID: 32521155

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Menopausal Hormone Therapy and Long-term Breast Cancer Risk: Further Data From the Women's Health Initiative Trials. Minami CA, Freedman RA. JAMA. 2020 Jul 28;324(4):347-349. doi: 10.1001/jama.2020.9620.PMID: 32720989

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Factors Influencing Physician Practices' Adoption of Behavioral Health Integration in the United States: A Qualitative Study. Malâtre-Lansac A, Engel CC, Xenakis L, Carlasare L, Blake K, [et al.] Friedberg MW. Ann Intern Med. 2020 Jul 21;173(2):92-99. doi: 10.7326/M20-0132. Epub 2020 Jun 2.PMID: 32479169

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Just-in-time postnatal education programees to improve newborn care practices: needs and opportunities in low-resource settings. Subramanian L, Murthy S, Bogam P, Yan SD, Marx Delaney M, [et al.] Semrau KEA. BMJ Glob Health. 2020 Jul;5(7):e002660. doi: 10.1136/bmjgh-2020-002660.PMID: 32727842

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siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice. Tao W, Yurdagul A Jr, Kong N, Li W, Wang X, [et al.] Shi J. Sci Transl Med. 2020 Jul 22;12(553):eaay1063. doi: 10.1126/scitranslmed.aay1063.PMID: 32718990

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Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, [et al.] Gladyshev VN. Cell Rep. 2020 Jul 28;32(4):107949. doi: 10.1016/j.celrep.2020.107949.PMID: 32726638

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Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hypertension: a retrospective cohort study. Maron BA, Brittan EL, Hess E, Waldo SW, Barón AE, [et al.] Choudhary G. Lancet Respir Med. 2020 Jul 27:S2213-2600(20)30317-9. doi: 10.1016/S2213-2600(20)30317-9. Online ahead of print.PMID: 32730752

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Regulatory approval characteristics of antimicrobial versus non-antimicrobial products, 1984-2018: an evaluation of Food and Drug Administration flexibilities. Darrow JJ, Najafzadeh M, Stefanini K, Kesselheim AS. Lancet Infect Dis. 2020 Jul;20(7):e159-e164. doi: 10.1016/S1473-3099(20)30197-3. Epub 2020 Jun 2.PMID: 32502431 Review.

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Understanding Debriefing: A Qualitative Study of Event Reconstruction at an Academic Medical Center. Sweeney RE, Clapp JT, Arriaga AF, Muralidharan M, Burson RC 2nd, [et al.] Fleisher LA. Acad Med. 2020 Jul;95(7):1089-1097. doi: 10.1097/ACM.0000000000002999.PMID: 31567173

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Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Hatabu H, Hunninghake GM, Richeldi L, Brown KK, Wells AU, [et al.] Lynch DA. Lancet Respir Med. 2020 Jul;8(7):726-737. doi: 10.1016/S2213-2600(20)30168-5.PMID: 32649920

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Trauma-Informed Medical Education (TIME): Advancing Curricular Content and Educational Context. Brown T, Berman S, McDaniel K, Radford C, Mehta P, Potter J, Hirsh DA. Acad Med. 2020 Jul 14. doi: 10.1097/ACM.0000000000003587. Online ahead of print.PMID: 32675789

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Multifaceted deregulation of gene expression and protein synthesis with age. Anisimova AS, Meerson MB, Gerashchenko MV, Kulakovskiy IV, Dmitriev SE, Gladyshev VN. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15581-15590. doi: 10.1073/pnas.2001788117. Epub 2020 Jun 23.PMID: 32576685

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Food insecurity as a risk factor for preterm birth: a prospective facility-based cohort study in rural Haiti. Richterman A, Raymonville M, Hossain A, Millien C, Joseph JP, [et al.] Ivers LC. BMJ Glob Health. 2020 Jul;5(7):e002341. doi: 10.1136/bmjgh-2020-002341.PMID: 32611679

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Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease. Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, [et al.] Martineau AR.N Engl J Med. 2020 Jul 23;383(4):359-368. doi: 10.1056/NEJMoa1915176.PMID: 32706534 Clinical Trial.

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Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Moll M, Sakornsakolpat P, Shrine N, Hobbs BD, DeMeo DL, [et al.] Cho MH. Lancet Respir Med. 2020 Jul;8(7):696-708. doi: 10.1016/S2213-2600(20)30101-6.PMID: 32649918

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Hospital Investments in Housing-Banner of Change or Red Flag? Gondi S, Beckman AL, McWilliams JM. JAMA Intern Med. 2020 Jul 20. doi: 10.1001/jamainternmed.2020.2348. Online ahead of print.PMID: 32702105

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SGLT2 Inhibitor: Not a Traditional Diuretic for Heart Failure. Verma A, Patel AB, Waikar SS. Cell Metab. 2020 Jul 7;32(1):13-14. doi: 10.1016/j.cmet.2020.06.014.PMID: 32640243

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Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. Wilflingseder J, Willi M, Lee HK, Olauson H, Jankowski J, [et al.] Bonventre JV. Nat Commun. 2020 Jul 7;11(1):3383. doi: 10.1038/s41467-020-17205-5.PMID: 32636391

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NRP1 cripples immunological memory. Acharya N, Anderson AC. Nat Immunol. 2020 Jul 28. doi: 10.1038/s41590-020-0759-5. Online ahead of print.PMID: 32724188

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Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. Xiao S, Bod L, Pochet N, Kota SB, Hu D, [et al.] Kuchroo VK. Cell Rep. 2020 Jul 14;32(2):107892. doi: 10.1016/j.celrep.2020.107892.PMID: 32668241

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US Spending Associated With Transition From Daily to 3-Times-Weekly Glatiramer Acetate. Rome BN, Tessema FA, Kesselheim AS. JAMA Intern Med. 2020 Jul 20:e202771. doi: 10.1001/jamainternmed.2020.2771. Online ahead of print.PMID: 32702083

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Delayed Denosumab Injections and Fracture Risk Among Patients With Osteoporosis: A Population-Based Cohort Study. Lyu H, Yoshida K, Zhao SS, Wei J, Zeng C, [et al.] Solomon DH. Ann Intern Med. 2020 Jul 28. doi: 10.7326/M20-0882. Online ahead of print.PMID: 32716706

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Predicting erenumab adverse events with single-cell genomics. Vgontzas A, Renthal W. Lancet. 2020 Jul 11;396(10244):95-96. doi: 10.1016/S0140-6736(19)32952-6.PMID: 32653068

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Universal Masking in the Covid-19 Era. Klompas M, Morris CA, Shenoy ES. N Engl J Med. 2020 Jul 9;383(2):e9. doi: 10.1056/NEJMc2020836. Epub 2020 Jun 3.PMID: 32492295

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Converging pandemics: implications of COVID-19 for the viral hepatitis response in sub-Saharan Africa. Gupta N, Desalegn H, Ocama P, Lacombe K, Njouom R, [et. al] Kateera F. Lancet Gastroenterol Hepatol. 2020 Jul;5(7):634-636. doi: 10.1016/S2468-1253(20)30155-2.PMID: 32553140

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PRIME Time in Rheumatoid Arthritis. Gravallese EM, Robinson WH. N Engl J Med. 2020 Jul 16;383(3):278-279. doi: 10.1056/NEJMe2018218.PMID: 32668119

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COVID-19 preparedness in Malawi: a national facility-based critical care assessment. Sonenthal PD, Masiye J, Kasomekera N, Marsh RH, Wroe EB, [et al.] Rouhani SA. Lancet Glob Health. 2020 Jul;8(7):e890-e892. doi: 10.1016/S2214-109X(20)30250-3. Epub 2020 May 25.PMID: 32464111

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Adverse Effects of Low-Dose Methotrexate. Solomon DH, Sparks JA. Ann Intern Med. 2020 Jul 21;173(2):167. doi: 10.7326/L20-0525.PMID: 32687751

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Biobanks could identify medically actionable findings relevant for COVID-19 clinical care. Stergachis AB, Weiss ST, Green RC. Nat Med. 2020 Jul;26(7):991. doi: 10.1038/s41591-020-0953-x.PMID: 32541961

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Professionalism 101 for Black Physicians. AbdelHameid D. N Engl J Med. 2020 Jul 30;383(5):e34. doi: 10.1056/NEJMpv2022773. Epub 2020 Jul 14.PMID: 32663911

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Inequity in Crisis Standards of Care. Cleveland Manchanda E, Couillard C, Sivashanker K. N Engl J Med. 2020 Jul 23;383(4):e16. doi: 10.1056/NEJMp2011359. Epub 2020 May 13.PMID: 32402154

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Dystopian Diary of a Medical Resident. Vise AS. JAMA Intern Med. 2020 Jul 20. doi: 10.1001/jamainternmed.2020.2780. Online ahead of print.PMID: 32702092 No abstract available.

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How to Obtain a Nasopharyngeal Swab Specimen. Reply. Marty FM, Chen K, Verrill KA. N Engl J Med. 2020 Jul 16;383(3):e14. doi: 10.1056/NEJMc2015949. Epub 2020 May 29.PMID: 32469478

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Drug Prices, Rebates, and Discounts. Rome BN, Feldman WB, Kesselheim AS. JAMA. 2020 Jul 28;324(4):399. doi: 10.1001/jama.2020.7983.PMID: 32720997 No abstract available.

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Creating Real Change at Academic Medical Centers - How Social Movements Can Be Timely Catalysts. Morse M, Loscalzo J. N Engl J Med. 2020 Jul 16;383(3):199-201. doi: 10.1056/NEJMp2002502. Epub 2020 Jun 10.PMID: 32521157

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Differential effect of ticagrelor on irreversible harms in diabetes - Authors' reply. Bhatt DL, Steg PG. Lancet. 2020 Jul 11;396(10244):93-94. doi: 10.1016/S0140-6736(20)30479-7.PMID: 32653065 No abstract available.

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Web Exclusive. Annals On Call - Why Do Patients Develop Anemia With Chronic Inflammation? Centor RM, Vallurupalli M. Ann Intern Med. 2020 Jul 21;173(2):OC1. doi: 10.7326/A19-0034.PMID: 32687765 No abstract available.

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