The RNA Transcript, September 14, 2020 |
|
Our members' promotions:
four Associate Professors and one Professor!
|
|
The Board of Regents of May 21st, 2020, approved recommendations for new appointments and promotions for regular associate and full professor ranks on the University of Michigan. The following Center for RNA Biomedicine's members were further appointed:
Alan P. Boyle, associate professor of computational medicine and bioinformatics, with tenure; associate professor of human genetics, without tenure, Medical School -- see our "Featured Scientist"
Deepak Nagrath, associate professor of biomedical engineering, with tenure, College of Engineering and Medical School
Andrzej T. Wierzbicki, professor of molecular, cellular and developmental biology, with tenure, College of LSA
|
|
The University of Michigan Center for RNA Biomedicine involves over 155 faculty members and their labs across seven Schools and Colleges on the Ann Arbor campus. We're pleased to feature these outstanding scientists and colleagues in our weekly news. |
|
Assistant Professor, Biological Chemistry, Medical School
Research interests: In general, I’m interested in how and why bacteria make decisions. We have a love/hate relationship with bacteria: half the time we want them to make things for us, the other half, we want to kill them. Knowing how the regulatory logic of bacterial cells work, and especially how to manipulate that logic, helps us in both cases: In the synthetic biology context, we can optimize the expression of genes needed to make some biological product that we are interested in. In the infection context, we can (for example) block the expression of virulence genes to prevent disease.
|
|
“A small RNA based innate immune system”
|
|
Monday, September 21, 4:00 – 5:00 pm | U-M Center for RNA Biomedicine
“Structures of eukaryotic RNases MRP/P RNPs reveal RNA-driven protein remodeling”
Keywords: Ribozymes, RNase P, RNase MRP, ribonucleoprotein complexes, RNA-driven protein remodelling
|
|
|
Thursday, September 24, 4:00 – 5:00 pm | U-M Center for RNA Biomedicine | ZOOM
The RNA Journal Club meets to prepare for seminars and engage with their presenters. The Club studies and reviews the articles relating to upcoming talks.
In preparation for the 9/29 RNA Seminar with guest speaker Hiro Suga, we will review: "Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis" Rumit Maini, Hiroyuki Kimura, Ryo Takatsuji, Takayuki Katoh, Yuki Goto, and Hiroaki Suga https://pubs.acs.org/doi/pdf/10.1021/jacs.9b11097
|
|
Wednesday, September 23, 8:45 am–3:15 pm |
This year’s event focuses on the important role of community participants in research and the positive impact research can have on communities. Featuring national and local experts from a variety of precision health disciplines, this event will provide thought-provoking sessions from multiple perspectives.
|
|
Wednesday-Friday, September 23–25 |
"RNA Biology and Technology – The Current Pandemic and Beyond"
Keynote speakers
- Lynne Maquat, University of Rochester, Rochester
- Stanley Perlman, University of Iowa, Iowa
- Mariano A. Garcia-Blanco, UTMB, Texas
Moderation and discussion: Phillip Sharp, MIT, Cambridge
|
|
A line up of outstanding RNA scientists from the US and around the world. All times are EDT.
-
Monday, September 21, 4:00 pm, Andrey Krasilnikov, Penn State
-
Monday, September 28, 9:00 am, Hiroaki Suga, University of Tokyo, Japan
- Monday, October 5, 4:00 pm, Chase Weidmann, Washington University School of Medicine in St. Louis
-
Monday, October 19, 4:00 pm, Gene Yeo, University of California, San Diego
-
Monday, October 26, 9:00 am, Aleksandra Filipovska, University of Western Australia, Australia
-
Monday, November 9, 9:00 am, Jeff Twiss, University of South Carolina
-
Monday, November 16, 4:00 pm, Michelle Hastings, Chicago Medical School, Rosalind Franklin University of Medicine and Science
-
Monday, December 7, 4:00 pm, John Mattick, Garvin Institute of Medical Research, RNA Biology and Plasticity Lab, Darlinghurst, Australia
-
Monday, December 14, 4:00 pm, Narry Kim, Seoul National University
-
Monday, January 25, 2021, 4;00 pm, Elena Conti, Max Planck Institute of Biochemistry, Germany
|
|
Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are recent highlights.
|
|
Direct kinetic fingerprinting and digital counting of single protein molecules, Tanmay Chatterjee, Achim Knappik, Erin Sandford, Muneesh Tewari, Sung Won Choi, William B. Strong, Evan P. Thrush, Kenneth J. Oh, Ning Liu, Nils G. Walter, and Alexander Johnson-Buck, Proc Natl Acad Sci U S A. 2020;202008312. doi:10.1073/pnas.2008312117
Illustration: Kinetic fingerprinting with dynamically binding fluorescent antibodies (cyan with red glowing orb) distinguishes between the repetitive binding to a specific target protein (left) and the less repetitive nonspecific binding to other proteins (right) captured on a surface using conventional IgG antibodies (blue Y-shaped molecules, bottom). The highly specific single-molecule detection of this approach provides approximately 100-fold higher sensitivity than conventional protein detection assays such as ELISA.
|
|
Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson Guilherme, Mark Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl Bellvé, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Lee S. Weinstein, Jiandie D. Lin, Paul Cohen, Michael Czech, Cell Rep. 2020;32(5):107998. doi:10.1016/j.celrep.2020.107998
Highlights:
- Light sheet microscopy reveals nerve fibers abutting beige adipocytes in iWAT
- iWAT denervation blocks cold-induced but not adipocyte FASNKO-induced iWAT beiging
- cAMP/PKA pathway in adipocytes mediates iWAT beiging in adipocyte FASNKO mice
- Macrophages but not innervation are required for beiging in adipocyte FASNKO mice
|
|
Keywords: dyskeratosis, congenitatelomerase, TERC, PAPD5, PARN, bone marrow failure
|
|
University of Michigan Medical School
November 9–11, 2020
This recruiting event awards 20 upper-level graduate students the opportunity to explore the extensive postdoctoral research and training opportunities in biomedical sciences available at the University of Michigan.
During a three-day virtual visit, invited candidates will interview with prospective mentors, network with current postdocs, and learn about life in Ann Arbor. Applicants are selected from a national pool of candidates who expect to complete their thesis research by Summer 2021.
Applications are open until September 30, 2020. Interested candidates can visit U-M Medical School sites for more information or to apply.
|
|
|
|
SHARE YOUR NEWS AND COMMENTS
|
|
|
|
|
|
|
