HIRN WEBINAR * ALL WELCOME |
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The Human Islet Research Enhancement Center (HIREC) will be hosting a webinar on "Designing Tools and Materials to Create a Benchtop Window into the Islet-immune Interface"to highlight advancements of the Consortium of Human Islet Biomimetics (CHIB).
The goal of this public webinar is to share HIRN advancements with the scientific community.
Meeting Information:
Date: Tuesday, March 2, 2021
Time: 12:00 PM, PT | 3:00 PM, ET
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JDRF nPOD ANNUAL VIRTUAL MEETING |
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nPOD Annual Meeting
The 13th Annual Network for Pancreatic Organ Donors with Diabetes (nPOD) Scientific Meeting will be held virtually from February 22 – 24, 2021. All are welcome to participate but advance registration is required and closes on Friday, February 19 at 6:00 pm ET. Learn more about the meeting HERE.
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HPAP has produced a wealth of single-cell transcriptomics data over the years, but the latest project co-led by Vahedi, Kaestner, Naji and Faryabi groups, went further to employ four single-cell techniques (scRNA-seq, CyTOF, spatial proteomic IMC, and immunofluorescence staining) on pancreatic islets of T1D, autoantibody-positive, and non-diabetic organ donors from the HPAP. One interesting application of their multimodal analysis was the profiling of rare “Hybrid” cells that appear to be present across all donor groups. These cells exhibit gene signatures of both endocrine and exocrine cells and appear to have distinct subtypes. The group also used the multimodal approach to study MHC Class II-expressing ductal cells. While there have been other studies that confirmed MHC class II overexpression in T1D islets, theirs may be the first study to look at MHC class II presentation specifically in ductal cells and to suggest that this could potentiate immune cells in the T1D context.
To better share the results and data from the project, the Vahedi group developed a web portal where other researchers can explore expression of a gene of interest with a cell type and/or donor group of interest. Given that the study represents each cell type/subtype as a node in a dendogram, one can select any of these nodes (subtypes) that were defined, making it possible to go deeper into, for instance, the Beta-1 versus the Beta-2 subtypes or the Hybrid cell subtypes. Most other applications offer more general groupings, but this web portal shows an appreciation of cellular heterogeneity and reminds us of how much remains still in understanding the islet ecosystem, especially for T1D.
Latest version of the paper HERE
Accompanying web portal HERE (RRID:SCR_020952)
*Note that some institutional firewalls may prevent access.
→ Contact us if you have any scientific breakthroughs to share!
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Office Hours (Standing Zoom Invite) (First Thursday of the Month from 2-3pm Eastern/11am-12pm Pacific).
Password: 123456
Dial: +1 415 762 9988 (US Toll)
Meeting ID: 955 4466 1617
Learn more about:
- HIRN Resources: How to enter a new resource or search existing resources
- How to get an RRID for a resource
- How to make your protocols more widely available on protocols.io *
- How to Dockerize your pipeline/application code *
- FAIR: Is your research FAIR? Get suggestions on your output
- How to make your data more FAIR by depositing in Zenodo *
- Social Media: Learn how to self-promote your research and/or lab
- And any other HIRN-related questions you may have!
Moderators:
Human Islet Research Enhancement Center (HIREC) at City of Hope:
-Layla Rouse, MS, HIRN Program Manager
-Anh Nguyet Vu, Scientific Data Coordinator
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100 YEAR INSULIN ANNIVERSARY |
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To celebrate the 100 year anniversary of the discovery of human insulin the University of Toronto is hosting a free virtual meeting on April 14-16, 2021. Additionally, they are sponsoring Trainee & Early Career Investigator Awards. Abstracts are due March 1. The Scientific Symposium will provide comprehensive updates on the latest advances in diabetes treatment and management through a series of online educational sessions and live, online, panel discussions with the experts. To register for this event please click HERE.
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THE WHO GLOBAL DIABETES COMPACT |
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On World Diabetes Day, WHO (World Health Organization) announced the development of
the Global Diabetes Compact, a comprehensive and inclusive approach to support countries in implementing effective programmes for the prevention and management of diabetes. The Compact will bring together in one package all WHO materials for the prevention and management of diabetes, both existing and new. The Compact will be launched in April 2021. Read more HERE.
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SUMMER STUDENT INTERNSHIP |
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dkNET Summer of Data Student Internship Program
The 2021 dkNET Summer of Data Student Internship program provides students an opportunity to utilize the dkNET tools and resources in a research project and to provide feedback on their experience to the dkNET team. Don't miss this great opportunity to learn best practices to enhance rigor and reproducibility and learn the basics of good data management by following the FAIR (Findable, Accessible, Interoperable, Reusable) data principles! The program is a 6-week online program, and selected students will receive $1,000 awards. Research projects should be in the areas of the NIDDK including diabetes, obesity, nutrition, digestive, kidney, liver, urologic, endocrine, metabolic, bone, and blood diseases. Preference will be given to those projects that would most benefit from the types of services offered by dkNET, e.g., projects that involve antibodies, genetically modified organisms, and ‘omics’ data. The program is designed for both bench and bioinformatics scientists. No programming skills are required. For more information please click HERE.
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The dkNET (NIDDK Information Network) is inviting you to join them for a webinar "Population-Based Approaches to Investigate Endocrine Communication" on Friday, February 26, 2021, 11 am - 12:00 pm PST.
Mechanisms of inter-organ signaling have been established as hallmarks of nearly every pathophysiologic condition, where many exist as related and complex diseases. While significant work has been focused on understanding how individual cell types contribute and respond to specific perturbations related to common, complex disease, an equally-important but relatively less-explored question involves how relationships between organs are altered in the context of an integrated living organism. Current technical advances, such as proteomic analysis of plasma or conditioned media, have allowed for a more unbiased visualization and discovery of additional inter-tissue signaling molecules. Presenter: Dr. Marcus Seldin. Register HERE.
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Diabetes Research Centers Virtual Seminar Series
To address the disruption in seminars & scientific interactions at the onset of the Covid-19 pandemic, nine NIDDK-sponsored Diabetes Research Centers (DRCs) and three Centers for Diabetes Translational Research (CDTRs) established a weekly Virtual Seminar series. The series has been well-received and will continue. Anyone can register for the seminars, which are free and open to the public (registration required).
Speaker: Dr. Debbie Thurmond, Professor, City of Hope.
Date: March 10, 2021 at 2:00 pm Eastern.
Title: Insulin secretion and peripheral Insulin Action: Orchestrating better harmony.
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RFA-RM-21-010: Cellular Senescence Network: Consortium Organization and Data Coordinating Center (U24 Clinical Trial Not Allowed)
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Application due date: March 8, 2021
- Foreign applications are allowed
RFA-RM-21-009: Cellular Senescence Network: Technology Development and Application (UG3/UH3 Clinical Trial Not Allowed)
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Application due date: March 8, 2021
- Foreign applications are allowed
RFA-RM-21-008: Cellular Senescence Network: Tissue Mapping Centers
(U54 – Clinical Trial Not Allowed)
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Application due date: March 8, 2021
- Foreign applications are allowed
dkNET New Investigator Pilot Program in Bioinformatics: The dkNET New Investigator Pilot Program is designed to: (i) facilitate the ability of Early Stage and New Investigators with computational and bioinformatics expertise to pursue research questions in DEMD, or (ii) allow Early Stage and New PIs currently pursuing DEMD-related research to explore incorporating computational, mathematical, statistical, and/or bioinformatics approaches into their research projects.
- Award Budget: Awards are limited to $ 150,000 Direct Costs over the lifetime of the award (up to 2 years), plus applicable F&A costs to be determined at the time of award
- Application Due Date: February 26, 2021
PAR-20-140: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
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Application due date: Standard dates apply
- Foreign applications are allowed
F31 PAR-19-378: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
F32 PAR-19-379: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
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Program Director for Diabetes Behavioral Science
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking a clinical behavioral scientist to serve as Program Director for Diabetes Behavioral Science. The Program Director will play an active role in stimulating new research and managing ongoing grant portfolios focused on understanding the interaction between behavioral, psychological, and biological factors to inform development of more effective and targeted interventions to prevent and treat diabetes. Apply Here
Program Director for Health Equity in diabetes
Program Officials
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring program officials with expertise in translational research involving stem cell biology, regenerative medicine and human pathophysiology as it relates to Diabetes, Endocrinology and Metabolic Diseases. The mission of the Division of Diabetes, Endocrinology and Metabolic Diseases is to support broad-based research programs focused on both basic and clinical research in the areas of type 1 and type 2 diabetes and other metabolic diseases, including cystic fibrosis; endocrinology and endocrine diseases; obesity, neuroendocrinology, and energy balance; and development, metabolism, and basic biology of liver, fat, and endocrine tissues. DEM also provides funding for the training and career development of individuals committed to academic and clinical research careers in these areas. Apply Here
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Research Scientist
The University of Chicago beta cell/diabetes research group under the direction of Dr. Raghu Mirmira has funded openings for several postdoctoral research scientists with interest in applying/learning cell biological techniques (immunoprecipitation, immunohistochemistry, confocal imaging), mouse genetic skills, human islet biology, and immunology and inflammation research. NIH-funded research projects in the Mirmira laboratory include the study of beta cell development and function, human islet gene regulation and mRNA translation, and islet cytokine signaling in the context of type 1 diabetes. Please send your CV, cover letter, and contact information with 3 references to Dr. Mirmira.
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Research Scientist
The University of Washington Diabetes Research Center (DRC) Cell Function Analysis Core is recruiting a Research Scientist working to work on isolation of islets and other cell types using microsurgical and gradient purification techniques and cell culture; and investigating the function, bioenergetics and intracellular signaling in cells/islets from normal and diabetic models/patients using a variety of assays including sophisticated, real-time spectroscopic and imaging techniques. In addition, effort will be spent on the development of instrumentation for cell analysis that involves the design, implementation, testing and optimization of optical sensors and microfluidics. Please send your CV, cover letter, and contact information with 3 references to Dr. Sweet.
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Research Position
The laboratory of Dr. Vincent Poitout has a PhD position available for those interested in cell biology, signalling and glucose homeostasis. The laboratory is focused on pancreatic beta-cell biology and its perturbations in type 2 diabetes. The objective of this project is to explore the mechanisms whereby the pancreatic betacell increases its functional mass during puberty and their impact on glucose homeostasis in adulthood, using a combination of in vitro and in vivo approaches. The successful applicant will hold an MSc. degree in biochemistry, cell biology or physiology (or equivalent) and be eligible to the biochemistry, pharmacology or physiology programs at the University of Montreal. The candidate will receive a scholarship according to the guidelines of the Canadian Institutes of Health Research. Application to training awards from funding agencies is strongly encouraged. Please send your CV, cover letter, and contact information with 3 references to Dr. Poitout.
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Faculty Position
The Lilly Diabetes Center of Excellence (LDCE) at the Indiana Biosciences Research Institute (IBRI) is recruiting promising young investigators to start their own independent laboratories under excellent research conditions. The LDCE is recruiting high-potential Principal Investigators (PIs) at the IBRI in Indianapolis, Ind., who are interested in pancreatic beta cell research, particularly related to iPSC-derived beta cells and the crosstalk between beta cells and the immune system in type 1 diabetes (T1D). Please send your CV, cover letter, and contact information with 3 references to Dr. Eizirik.
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Faculty Position
The Diabetes Center of Excellence at the University of Massachusetts Medical School invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment. Please send your CV, cover letter, and contact information with 3 references to Dr. Harlan.
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Faculty Position
The Diabetes Clinical Research Program (DCRP) at Benaroya Research Institute at Virginia Mason (BRI) seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement. The DCRP is an international leader in type 1 (autoimmune) diabetes research. We are looking for an investigator with strong interest in clinical research and clinical trials to take a leadership role within the DCRP and work on national, regional, and local projects in type 1 diabetes. Experience in epidemiology, clinical investigation and/or clinical trials preferred; however, applicants with related research experience will be considered including work outside of type 1 diabetes. Requires an MD and a license to practice medicine in US. Please send your CV, cover letter, and contact information with 3 references to Dr. James.
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Postdoctoral Position
The Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute is seeking creative and highly motivated individuals for the position of Postdoctoral Associate under the direction of Dr. Todd Brusko. The Postdoc will be engaged in studying novel pathways regulating the differentiation and pathogenicity of T cells, the function of regulatory T cell biology in autoimmunity. Please send your CV, cover letter, and contact information with 3 references to Dr. Brusko.
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Postdoctoral Position
The laboratory of Dr. Amelia Linnemann at the Indiana University Diabetes Center has an opening for a PhD and/or MD postdoctoral research scientist with skills in cell/molecular biological techniques (immunoprecipitation, western blotting, cloning) and/or microscopy. Research projects in the Linnemann laboratory include the study of pancreatic islet dysfunction and cytokine signaling in the context of type 1 and type 2 diabetes, with a focus on autophagy and the antioxidant response. Interested applicants are encouraged to send an updated CV and names of 3 references to Dr. Amelia Linnemann, PhD, Assistant Professor, Department of Pediatrics, Indiana University School of Medicine.
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Postdoctoral Position
Pacific Northwest National Laboratory has a postdoctoral position available to join their multi-disciplinary team focused on mass spectrometry (MS) based omics analyses. This project is part of the Human Islet Research Network funded by the National Institute of Health. We are investigating the roles of alternative splicing in beta cell stress and development of type 1 diabetes. Interested candidates please send your CV, cover letter, and contact information with 3 references to Dr. Nakayasu.
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Postdoctoral Position
The University of Florida under the Stabler laboratory is seeking a creative and dedicated postdoctoral associate to join their team in working on translational research in Type 1 diabetes. The research goals for this position are in the translation of our bioactive scaffolds and coatings into preclinical models for validation and optimization. As a highly collaborative laboratory, the Associate will integrate as a part of our team, working together with members of the laboratory, as well as our extensive researcher network. The Associate will be expected to take a leadership role in the laboratory, directing research goals and timelines, mentoring students, and writing reports and publications. Interested candidates should submit a CV, a summary of future research interests and goals, and three references to Dr. Cheri Stabler.
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Postdoctoral Position
A postdoctoral research associate position is available in the Hughes Lab at the Washington University School of Medicine to study primary cilia in islet cells. The laboratory combines standard molecular and cell biology with advanced imaging techniques to explore novel roles of cilia in mouse and human islets. We have generated new cilia knockout mouse models with strong diabetic phenotypes and are looking for someone to lead the investigation of cilia-mediated signaling mechanisms in islet hormone secretion. For human studies, we have a funded project to image primary cilia in T1D pancreas which will generate important and clinically relevant findings in autoimmune diabetes. Interested candidates please email Dr. Jing Hughes. Please send your CV, cover letter, and contact information with 3 references to Dr. Hughes.
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Postdoctoral Position
Postdoctoral Scholar Positions in Microphysiological Systems (“Tissue Chips”) in the Hughes Lab. An NIH-funded postdoctoral position is available to work on the development of body-on-chip devices in the areas of pancreatic islets (Type 1 diabetes). The ideal candidate will have experience in cell culture, vascular biology, bioengineering (including COMSOL modeling), and microfluidic systems. Prior knowledge in the areas of diabetes would be an advantage, however, candidates with any combination of the above should consider applying. Please send your CV, cover letter, and contact information with 3 references to Dr. Hughes.
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Postdoctoral Position
The Arrojo e Drigo lab focuses on the mechanisms regulating post‐mitotic cell homeostasis and longevity. Many postmitotic cells can be as old as the organism, which makes them remarkably long‐lived. We study long‐lived cells in different organs and explore their developmental trajectory, structure‐function and aging patterns. Our lab uses a combination of single cell sequencing and high‐resolution light, electron and isotope microscopy platforms to overlay cell structure‐function with molecular identity, age and metabolism. Applications are invited for a postdoctoral position to study the physiology of long‐lived cells in the pancreas. Please send your CV, cover letter, and contact information with 3 references to Dr. Arrojo e Drigo.
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Postdoctoral Position
Our laboratory is studying pancreatic beta-cell biology and its perturbations in type 2 diabetes. The objectives of project are to decipher the physiological role of the fatty-acid receptor FFAR4 (GPR120) in pancreatic islet hormone release and to identify its intracellular signaling mechanisms. The successful applicant will hold a PhD or equivalent. Experience in islet biology and/or glucose homeostasis is required. Please send your CV, cover letter, and contact information with 3 references to Dr. Poitout.
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Postdoctoral Position
The Voight lab invites applications for a computational Post-Doctoral position at the University of Pennsylvania School of Medicine, within the Department of Systems Pharmacology and Translational Therapeutics and the Department of Genetics. The lab focuses on translating discoveries from human genetics data into insights about the biological basis and genetic architecture of human disease (ultimately toward developing new therapeutics targets for human disease), and understanding selection
during recent human evolution. The candidate will have a MD, PhD, or equivalent doctorate, with a strong background in one or more of the following areas: statistics, biostatistics, population genetics, human genetics, genetic epidemiology, computational biology and/or genomics, bioinformatics. Please send your CV, cover letter, and contact information with 3 references to Dr. Voight.
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Postdoctoral Position
A postdoctoral researcher position studying human islet biology is available in the laboratory of Dr. Ed Phelps. The postdoctoral researcher will work on currently funded NIH projects: R01 TBD “Mechanism and dynamics of islet GABA signaling” and HIRN UG3 DK122638 02 “Engineering a human microphysiological system for the characterization of islet-immune interactions”. A background in islet biology, neuroscience, or cell/molecular biology will beneficial to the success of the project. Please send your CV, cover letter, and contact information with 3 references to Dr. Phelps.
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We are seeking a highly motivated individual for a postdoctoral position in the Department of Pathology at the Children’s Hospital of Philadelphia. Our laboratory focuses on using human embryonic stem cell and iPS cell models to study human pancreatic development and diabetes. The NIH funded position aims to use the human ES/iPS system to study monogenic forms of diabetes using genome engineered stem cell lines. Applicants must have a PhD or MD degree in the biological or physical sciences. Prior laboratory experience in cell culture, basic molecular biology, and flow cytometry is preferred. The position is available Fall of 2020, with some flexibility for a later start date. Please send your CV, cover letter, and contact information with 3 references to Dr. Gadue.
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Postdoctoral Fellow
A fully-funded postdoctoral fellowship position is available in the Soleimanpour islet mitochondria laboratory, where we are interested on the interface of mitochondria and the ER in the development of type 1 diabetes (T1D). We are seeking highly motivated candidates (who possess a Ph.D., M.D., or equivalent degree) interested in conducting research focused on understanding molecular and genetic causes of diabetes. The fellow will be mentored in preparation of manuscripts, presentation of work at national/international meetings, and grant submissions to support their development of skills needed for the remainder of their career. Please send your CV, cover letter, and contact information with 3 references to Dr. Soleimanpour.
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Postdoctoral Fellow
Applications are invited for a Postdoctoral Fellow in Functional Genomics position that spans the laboratories of Drs. Steve Parker and Jacob Kitzman in the Departments of Computational Medicine & Bioinformatics and Human Genetics at the University of Michigan Medical School. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the noncoding portion of the genome (from GWAS), with a focus on type 2 diabetes. We accomplish this through an interdisciplinary combination of molecular/cellular and computational methods. We generate multiple high-throughput functional genomics data sets on the genome, epigenome, and transcriptome across species and in disease-relevant tissues/cells and use computational approaches to integrate and analyze this data. The applicant will help organize and lead research projects involving molecular biology, cell biology, genomics, and genetics, which involves critical evaluation and presentation of scientific literature. Please send your CV, cover letter, and contact information with 3 references to
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Postdoctoral Fellows
The Powers & Brissova research group in the Vanderbilt Diabetes Center is seeking a postdoctoral fellows to study human pancreas and islet biology with a focus on gene expression and developmental biology of single cells. We are especially interested individuals with computational or informatics
expertise, multimodal, multiplex imaging experience, or live cell imaging experience. Please send your CV, cover letter, and contact information with 3 references to Dr. Powers.
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Postdoctoral positions in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical School. Applications are invited for prospective Post-Doctoral Fellows to train in the Kulkarni Lab. The position is available immediately for a period of 2 years with the possibility of extending for a third year based on available funds and performance of the Fellow. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in exciting projects focused on defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis. Successful candidates should have a strong background in molecular biology, cell biology and biochemistry. It is strongly preferable to have prior experience in bioinformatics and the ability to interrogate “omics” and sequencing datasets. Prospective candidates should possess skills in handling human islets and undertake animal studies. It would be an advantage to be able to undertake rodent islet isolation, and perform immunostaining. Please send your CV, cover letter, and contact information with 3 references to
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Postdoctoral Associate
The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. Please send your CV, cover letter, and contact information with 3 references to Dr. Millman.
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Postdoctoral Associate
Rutgers, the State University of New Jersey, is seeking a Research Associate for the Child Health Institute of New Jersey. The position is available in El Ouaamari’s laboratory to investigate the role of the peripheral neurons in the regulation of systemic energy homeostasis in the context of obesity and diabetes. Self-driven, creative, resourceful and independent candidates with a PhD in neuroscience or neurobiology are encouraged to apply. Prior postdoctoral experience in neuroscience or related fields is required. Please send your CV, cover letter, and contact information with 3 references to Dr. El Ouaamari.
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Postdoctoral Associate
The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Cellular definition and stability of CD8 T cell exhaustion associated with response to therapy, and 3) identification of biomarkers of disease severity. The Postdoctoral Research Associate conducts independent biomedical research relevant to defining mechanisms underlying CD8 T cell exhaustion in the context of type 1 diabetes (T1D). The Postdoctoral Research Associate is a team-player who welcomes challenges and wants to grow as a translational biologist. Requires a Ph.D. in Immunology or a related field and experience in tissue culture, cellular and molecular techniques. Please send your CV, cover letter, and contact information with 3 references to Dr. Long.
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Postdoctoral Position
One postdoctoral fellow position is available at the Indiana Biosciences Research Institute are available in the IBRI Diabetes Center. We are looking for highly motivated researchers to join the IBRI in the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens. The selected candidate will participate in a team working with primary human and rodent islets, animal models of diabetes and human beta cell lines, and advanced molecular biology techniques. A strong understanding of beta cell biology and/or molecular biology is important. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the lab. Please send your CV, cover letter, and contact information with 3 references to Dr. Eizirik.
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Postdoctoral Position
We are looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging. Please send your CV, cover letter, and contact information with 3 references to
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project ” U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, ” where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The successful candidate will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff. Please send a cover letter and C.V. to Dr. Hiroyuki Nakai.
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Postdoctoral position in the Lab of Dr. Sangeeta Dhawan at the Beckman Research Institute at City of Hope, in Los Angeles county, CA to study the epigenetic regulation of pancreatic beta cell mass. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable. Please send your CV, cover letter, and contact information with 3 references to Dr. Dhawan.
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Postdoctoral position in the Lab of Dr. Doris Stoffers in the Institute for Diabetes, Obesity, and Metabolism within the Perelman School of Medicine at the University of Pennsylvania. A PhD is required; experience in genetic mouse models, islet physiology, advanced molecular techniques, high throughput sequencing methodologies and bioinformatics, proteomics, metabolomics is helpful. Please send your CV, cover letter, and contact information with 3 references to Dr. Stoffers.
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Research Associate II
The Arrojo e Drigo laboratory at Vanderbilt University, has a research assistant II position open. This position requires knowledge of laboratory procedures, record keeping, validated experience in animal handling and anatomy, animal colony management, and standard molecular biology procedures. The research assistant II will support ongoing experiments in animal procedures, molecular biology, cell culture and microscopy. Motivated individuals will have their own projects and perform animal-related research. Additional responsibilities will include maintenance of and management of transgenic animal colonies and genotyping. Please send your CV, cover letter, and contact information with 3 references to Dr. Arrojo e Drigo.
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dkNET Community Liaison
The NIDDK Information Network has an open position for a Community Liaison to provide community outreach and lead engagement with the scientific community. This position will support a range of activities linked to community-dkNET partnerships, researcher engagement and knowledge networking. The position will entail engaging with research scientists, students and trainees, government, industry and broader audiences through workshops, in-person outreach events, multimedia, social media and Web-based systems. dkNET was launched by the FAIR Data Informatics Laboratory at the University of California, San Diego to serve the needs of basic and clinical investigators in diabetes, digestive and kidney disease by addressing the challenge of connecting researchers to research resources, assisting researchers with rigor and reproducibility guidelines, supporting researchers in navigating new data sharing requirements, and providing tools in enabling data discovery and hypothesis generation. More information click HERE.
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Research Technician
A new Stem Cell and Genome Editing Core Facility situated within the Kieffer Research Group has an opportunity for a highly motivated and collaborative technician to support diverse regenerative medicine research initiatives. The candidate will assist with the day to-day operation of the Core, will generate human induced pluripotent cells (iPSCs), and will culture and differentiate human embryonic stem cells (ESCs) and iPSCs down pancreatic lineages. Please send your CV, cover letter, and contact information with 3 references to Dr. Kiefer.
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