TODAY, January 15, 2021, 12p via Zoom

Today's Cancer Center Seminar features Jae Jung, PhD presenting, "TRIM56: Intracellular DNA Sensing Pathway and Nonalcoholic Fatty Liver Disease," on behalf of the Molecular Oncology Program at noon via Zoom.

Dr. Jung is Betsy DeWindt Chair, Department of Cancer Biology and Director, Global and Emerging Pathogen Research Center at Cleveland Clinic Lerner Research Institute and member of the Case CCC's Molecular Oncology Program. Dr. Jung’s lab has shown that TRIM25 induces the K63-linked ubiquitination of RIG-I RNA sensor and TRIM56 induces the mono-ubiquitination of cGAS (cyclic GMP-AMP synthase) DNA sensor, which both are critical for cytosolic viral nucleic sensing to induce host’s anti-viral innate immunity. On the other hand, his lab has also found that TRIM56 targets and stabilizes AMP kinase pathway to regulate fatty acid synthesis. TRIM56 deficient mice develop obesity and nonalcoholic fatty liver disease (NAFLD), a condition in which excess fat is stored in the liver, leading to cirrhosis and liver cancer. This indicates that TRIM56 may link cGAS-mediated DNA sensing with NAFLD.

Friday, January 22, 2021, 12p via Zoom

Next week's Cancer Center Seminar features William Tse, MD, MBA presenting, "Development of the CD4CAR- and Dual Targeting CAR T-Cell Therapy for Hematologic Malignancies" on behalf of the Hematopoietic and Immune Cancer Biology Program.

Dr. Tse is Deputy Director of MetroHealth Cancer Center and Director, Division of Hematology/Oncology at MetroHealth Medical Center. He is also a member of the Case Comprehensive Cancer Center's Hematopoietic and Immune Cancer Biology Program.

Dr. Tse’s research interests are focused on three major areas: 1) early phase cancer therapeutics, cellular and immunotherapies for blood cancers and other non-malignant disorders; 2) laboratory-based translational researches in normal and cancer stem cell signaling profiles and pre-clinical animal models for therapeutics.

The Case Comprehensive Cancer Center Office of Community Outreach and Engagement is pleased to present the 5th Annual Cancer Disparities Symposium, Navigating Cancer Disparities: Lessons Learned and How to Move Forward.

Registration is now open for this multi-disciplinary event for researchers, clinicians, health professionals, community outreach groups, community-based organizations, patient advocates and trainees. Keynote presentations will be delivered by renowned disparities researchers and community leaders, and a poster session highlighting academic research and community programs will provide a showcase of the depth and depth of work happening in this field.

Though the symposium is happening virtually, attendees will experience the conference using Whova, our official web-based conference app, to view presentations and ask questions in real-time, as well as network with others behind the scenes.

Multidisciplinary researchers, community agencies and organizations are invited to submit abstracts for presentation at the 5th Annual Cancer Disparities Symposium. Abstracts will be divided into two tracks: Scientific Research and Community Programs. Meritorious abstracts will be selected for pre-recorded presentations. Abstracts must be submitted electronically by 5 pm ET on Friday, January 29, 2021.

Otis W. Brawley, MD, an internationally-recognized expert in cancer prevention and control, will present the symposium's Scientific Keynote His work is focused on closing racial, economic and social disparities in prevention, detection and treatment of cancer in the United States and worldwide.

Worta McCaskill-Stevens, MD, a medical oncologist nationally known for her expertise in bringing clinical trials to the community will present the Community Keynote. Dr. McCaskill-Stevens is Chief of the Community Oncology and Prevention Trials Research Group, which houses the National Cancer Institute (NCI) Community Oncology Research Program (NCORP), a community-based clinical trials network launched in 2014.

As host site for the 2021 Great Lakes Breast Cancer Symposium, the Case Comprehensive Cancer Center encourages you to mark your calendar for the symposium scheduled for May 21, 2021.

The symposium highlights ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.

This year's event features two keynote speakers:

POSTPONED to July 11-13, 2022

The Case Comprehensive Cancer Center (Case CCC) and the National Center for Regenerative Medicine (NCRM) were greatly looking forward to CSC 2020, originally scheduled for August 4-6, 2020 at Tinkham Veale University Center at Case Western Reserve University. In light of recent events surrounding the COVID-19 pandemic, the CSC planning committee has made the difficult decision to postpone the conference until July 11-13, 2022.

In its fourth year, CSC 2022 will feature renowned thought leaders in the field of cancer stem cell research. This conference is guaranteed to offer cutting-edge keynote presentations from a variety of niches within the field. Attendees will join world-class investigators for this three-day summit and network with scientists and clinicians advancing cancer stem cell research and therapeutic applications.

Join this town hall, hosted by The Steven G. AYA Cancer Fund, to learn more about the research program they are contributing to, their legacy wellness programs, their nonprofit media brand for the AYA cancer community, Elephants and Tea, and how they are helping the cancer community know they are not alone in facing cancer, and so much more!

Join thought leaders from academia, government, and industry for AACR’s 2021 COVID-19 and Cancer virtual meeting. Emerging data in basic, clinical, and epidemiologic research related to COVID-19 and cancer will be presented in a mix of keynote lectures, forums, and symposia.

Session topics include:

Breast cancer continues to be the second most common cause of cancer death in women in the United States. Results from numerous clinical trials continue to expand diagnostic/prognostic tools, therapeutic options, and supportive care strategies. Healthcare professionals need to be educated on current and emerging scientific data to make evidence-based treatment decisions and to provide optimal care for patients with breast cancer.

The NCCN 2021 Virtual Congress™: Breast Cancer with Updates from the 2020 San Antonio Breast Cancer Symposium (SABCS) will provide expert insights on the current standard of care for patients with breast cancer and include the latest clinical research updates from the 2020 SABCS to assist clinicians in formulating breast cancer management strategies.

The Genomic Medicine Institute and Center for Personalized Genetic Healthcare at Cleveland Clinic invite you to join the virtual 4th Annual International PTEN Symposium: From Patient-Centered Research to Clinical Care. They are planning an engaging day with an emphasis on advances in the diagnosis, management and treatment of patients with PTEN Hamartoma Tumor Syndrome (PHTS).

Pier Paolo Pandolfi, MD, PhD, FRCP, senior scientist at the Renown Institute for Cancer and honorary professor of molecular biology at the University of Turin, will deliver the morning keynote address. Neil Friedman, MBChB, pediatric neurologist and director of quality, outcomes, and innovation at Barrow Neurological Institute at Phoenix Children’s Hospital, will deliver the afternoon keynote address on the neurological spectrum of PHTS. Other topics include hormone use and high-risk patients, gynecological cancer risks, updates on PTEN clinical trials, and autism. Please refer to the symposium agenda for more details about this year’s speakers and topics.

The AACR Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world.

Save the date! The 13th Annual AACI Clinical Research Innovation (CRI) Meeting will be held July 13-15, 2021. Information about the meeting format, abstract submissions, and registration will be made available in early 2021.