OCTOBER 2019
NEWSLETTER
Get to know our HIRN Projects

Contact PI : Maike Sander, MD
University of California, San Diego (UG3 DK122639 )

Project Summary : All organs in the body receive their nutrients through blood vessels. The goal of this project is to mimic this process in a culture system for human islets. To this end, we have developed a culture platform growing human islets that are supported and fed by perfused human blood vessels. Under these conditions, we expect the islets to behave much more like they do in the body. We will then use this platform to test how immune cells from the blood of people with type 1 diabetes respond to human beta cells. These experiments will provide insight into the mechanisms of beta cell killing in type 1 diabetes in a culture system comprised entirely of human cells.
New Trans-Network Committee (TNC) Members

Congratulations to the recently selected new members of the HIRN
Trans-Network Committee. The TNC consists of one investigator from each consortia and representatives from the NIH NIDDK and HIRN Enhancement Center (HIREC). As a HIRN member you are encouraged to contact your TNC member at any time if you have questions or would like to learn more about HIRN!
*Contact PI
Imaging the Pancreas in Diabetes, and Benign and Mailgnant Exocrine Pancreatic Disease

Date: January 13-14, 2020
Location : Natcher Conference Center, Bethesda, MD

Strategies for Clinical Imaging in Diabetes

Date: January 15, 2020
Location : Natcher Conference Center, Bethesda, MD
NIH Requests for Applications (RFAs)

F31 PAR-19-378 : Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases  
  • Application Due Date:  Standard dates apply 
  • Foreign applications allowed

F32 PAR-19-379 : Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases 
  • Application Due Date:  Standard dates apply 
  • Foreign applications allowed

RFA-GM-19-001: Methods to Improve Reproducibility of Human iPSC Derivation, Growth and Differentiation (SBIR) (R44 – Clinical Trial Not Allowed) 
  • $500,000 in direct cost per year for 5 years
  • Application due date: January 6, 2020
  • Foreign applications are not allowed

RFA-RM-19-014: Catalyst Award In Diabetes, Endocrinology and Metabolic Diseases  
  • $500,000 in direct cost per year for 5 years
  • Application due date: December 3, 2019
  • Foreign applications are not allowed

RFA-PAR-18-886 : New Par adigms in Tissue Communication-from mediators to metabolic function (RC2 Clinical Trials Optional)
  • Letter of Intent due: Six weeks prior to application due date
  • Application due dates: October 31, 2019; June 2, 2020
  • Foreign applications are not allowed
dkNET Funding Opportunities

  • $50,000 over one year
  • Application due date: December 4, 2019
JOB OPPORTUNITIES
Visit HIRN Website to view full posting details
Postdoctoral Position

We are looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging.
Postdoctoral Position

Postdoctoral position is available in the Stanger laboratory to study the pathogenesis of autoimmune diabetes using ex vivo models. The project will involve working within a team of bioengineers, stem cell biologists, and immunologists to understand autoimmune destruction of human beta cells. A background in immunity and/or beta cell biology is desirable.
Postdoctoral Position

The laboratory of Dr. Amelia Linnemann at the Indiana University Center for Diabetes and Metabolic Diseases has an opening for a PhD and/or MD postdoctoral research scientist to develop intravital microscopy techniques for pancreatic islet imaging, to build upon our recently published work. The ideal candidate will have skills in microscopy techniques (e.g., multiphoton imaging, confocal imaging, and/or superresolution microscopy) as well as mouse handling skills. 
Program Directors

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking a Clinical Health Psychologist to lead a program of behavioral research on diabetes within the Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM). The DDEM supports and provides leadership for research on the causes, prevention and treatment of diabetes and its complications, as well as other endocrine and metabolic diseases.

The NIDDK is seeking a Ph.D.- level scientist to lead a program of research on the neurobiology of energy balance and metabolic diseases within the Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM). The DDEM supports and provides leadership for research on the causes, prevention and treatment of diabetes and its complications, as well as other endocrine and metabolic diseases.

Physician to Oversee Diabetes Clinical Studies
The NIDDK at the NIH is seeking a talented Physician (M.D. or equivalent) with expertise relevant to type 1 and/or type 2 diabetes research to manage clinical studies and trials related to the prevention and treatment of diabetes and its complications. This position offers unique and exciting opportunities to provide scientific leadership and to administer grants in support of diabetes research in the US.

Faculty Positions

The  Diabetes Center of Excellence at the University of Massachusetts Medical School  invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment. 
Faculty Positions

The  University of California, San Diego   Department of Pediatrics is recruiting two tenure track faculty positions. An Associate or Full position in the area of basic biology of diabetes and metabolic disease. This is broadly interpreted to include individuals in the fields of cell biology, stem cells, immunology, genetics, or bioengineering, interested in studying disease-relevant mechanisms.

An Assistant position in the area of basic biology of diabetes and metabolic disease. This is broadly interpreted to include individuals in the fields of cell biology, stem cells, immunology, genetics, or bioengineering, interested in studying disease-relevant mechanisms.
Assistant & Associate Member
The Diabetes Clinical Research Program (DCRP) at  Benaroya Research Institute  seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement.
The  University of Miami Miller School of Medicine  Department of of Microbiology and Immunology is accepting applications for Assistant and Associate Professor level for investigators with research interests related to immunotherapy of cancer, autoimmunity, or infectious diseases. Applicants should have a Ph.D., M.D. or equivalent, at least 3 years of postdoctoral training.
Interested in small-molecule discovery and modulating beta-cell phenotypes? The Wagner lab in the Chemical Biology & Therapeutics Science (CBTS) Program at the Broad Institute , is accepting applications for postdoctoral fellow positions. We are looking for researchers interested in studying small molecule-mediated beta-cell proliferation and insulin secretion.
Applications are invited for prospective Post-Doctoral Fellows to train at the Joslin Diabetes Center , Harvard Medical School. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in the Kulkarni Lab on projects focused on defining pathways and mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis.
The Tang lab at UCSF is looking for a postdoctoral fellow to join the efforts on optimizing beta cell replacement therapy in preclinical mouse models. 
Postdoctoral position in the Lab of Dr. Sangeeta Dhawan at the  Beckman Research Institute  at  City of Hope , in Los Angeles county, CA to study the epigenetic regulation of pancreatic beta cell mass. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable. 
Postdoctoral position in the Lab of Dr. Doris Stoffers in the   Institute for Diabetes, Obesity, and Metabolism  within the  Perelman School of Medicine  at the  University of Pennsylvania . A PhD is required; experience in genetic mouse models, islet physiology, advanced molecular techniques, high throughput sequencing methodologies and bioinformatics, proteomics, metabolomics is helpful. 
Postdoctoral Position
The  Lab of Dr. Abdelfattah El Ouaamari   at  Rutgers University/Robert Wood Johnson Medical School is recruiting self-driven, creative and organized candidates with a PhD in neuroscience, biochemistry or molecular and cellular biology. The candidate must possess skills in manipulating and assessing neuronal activity.