UC Davis School of Veterinary Medicine
VETERINARY CENTER FOR CLINICAL TRIALS
|
|
Acute Kidney Injury - Evaluating Early Markers in Urine and Blood of Horses
The purpose of this study is to evaluate the usefulness of certain compounds in the blood and urine as biomarkers for kidney disease. These biomarkers (KIM-1, SDMA, NGAL, or Cystatin C) may be able to alert us to acute kidney disease before our currently available biomarkers (creatinine) can alert us.
|
Anal Sac Adenocarcinoma - Using New Technology to Assess Tumor Extent in Dogs
Apocrine gland anal sac adenocarcinoma is the most common malignant tumor of the anal sac in dogs. Multiple imaging modalities have been used to evaluate for metastasis in anal sac adenocarcinoma, but no standardized approach has been established. The aim of this study is to determine whether the combination of CT and PET is is more accurate for identification of tumor as well as tumor spread than CT alone.
|
|
FEATURED ONGOING CLINICAL TRIALS
|
Ventricular Arrhythmias - Reducing the Risk in Dogs During Chemotherapy
Although effective, one of the reported side effects of doxorubicin is the liberation of histamine, which can cause ventricular arrhythmias. The concurrent use of anti-histamine agents like diphenhydramine with doxorubicin therapy could possibly reduce these abnormal beats. Therefore, the aim of this study is to see if use of diphenhydramine can reduce the risk of arrhythmias sometimes associated with the administration of chemotherapy.
|
Hypertrophic Cardiomyopathy - Assessing a Treatment in Cats
Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats and we do not have a good understanding of how to best treat this devastating disease. Pimobendan has been shown to have significant clinical benefits in cats with HCM, but more studies are needed to evaluate exactly how this drug affects heart function. The purpose of this clinical trial is to evaluate the effects of pimobendan on heart function in cats affected with HCM.
|
 |
Ocular Squamous Cell Carcinoma -Understanding the Genetics in Haflinger, Beligan, Percheron, Appaloosa and Arabians Horses
Squamous cell carcinoma (SCC) is one of the most common forms of cancer to affect the eye and affects Haflingers, Belgians, Percherons, Appaloosas, and Arabians (among others). The objective of this study is to determine the incidence of SCC in the listed breeds, understand the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.
|
Diabetes Mellitus - Assessing a New Therapy for Maintaining Remission in Cats
The purpose of this study is to evaluate the benefit of Exenatide-ER for maintaining diabetic cats in remission (in an insulin-independent state).
|
Lymphoma - Understanding How the Body Processes a Chemotherapy Drug in Cats
Despite the wide use of chlorambucil in cats with small cell GI lymphoma, the pharmacokinetic parameters have not been previously studied in cats. Knowledge of the pharmacokinetic parameters of chlorambucil in this population of older, cancer-bearing cats is critical to understand why some cats experience side effects with chlorambucil therapy and determine if variability in the metabolism of chlorambucil contributes to treatment failure.
|
Feline Cancer - Understanding How the Body Processes the Chemotherapy Drug, Vinblastine, in Cats
Although vinblastine is commonly used in veterinary cancer therapy, most commonly for treating feline lymphoma, there is currently no information on how the drug is distributed and eliminated in these cats. This study aims to describe the pharmacokinetic profile of vinblastine in cats and to identify which characteristics or traits that can vary from one cat to another influence how vinblastine is distributed and eliminated in cats.
|
Equine Recurrent Uveitis - Treating and Understanding the Genetics (2 trials)
Trial #1 is assessing the use of stem cell therapy as a treatment for Equine Recurrent Uveitis.
Trial #2 aims to identify the genetic factors contributing to Equine Recurrent Uveitis in Appaloosa horses.
|
Corneal Endothelial Dystrophy - Understanding the Disease in Boston Terriers, German Shorthaired Pointers and German Wirehaired Pointers
Corneal endothelial dystrophy (CED) is a devastating disease that is commonly seen in Boston Terriers, German Shorthaired Pointers and German Wirehaired Pointers, thereby suggesting a genetic component. The purpose of this study is to identify the region of the dog genome associated with CED in these breeds with the ultimate goal of developing a genetic test for the disease.
|
Bilateral Corneal Stromal Loss - Understanding the Genetics in Friesian Horses
Bilateral corneal stromal loss (BCSL) is a potentially progressive ocular disease that can be associated with pain, vision loss and even loss of the eye. The objective of this study is to determine the role genetics plays in BCSL in Friesian horses. This study is designed to determine the incidence of BCSL in the breed, to determine the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.
|
Ureteral Obstructions - Evaluating Post-Surgery Outcomes of Cats Undergoing Ureteral Stent Placement
The purpose of this project is to record the intra-operative and postoperative complications associated with the procedure and determine the outcome of the procedure based on objective measures.
|
Chylothorax - Assessing a New Treatment in Dogs
The traditional combination of thoracic duct ligation and pericardectomy has been performed for many years. However, without good evidence of pericardial disease, the pericardectomy may not be necessary. This study aims to assess the effectiveness of doing a complete thoracic duct ligation alone in resolving chyle accumulation and provide a better understanding of the physiological response to thoracic duct ligation in dogs with idiopathic chylothorax.
|
Liver Tumors - Using a New Technique to Shrink Tumors in Dogs
When liver tumors in dogs cannot be removed with surgery, treatment options are limited or non-existent. In humans, one of the standard treatments for those cases is transarterial embolization (TAE), which eliminates the blood supply of the tumor and may decrease tumor size. Therefore, the objectives of this study are to 1) describe the procedure of TAE in a group of dogs with naturally-occurring liver cancer, and 2) evaluate the effect of TAE on clinical signs and the size of the tumor.
|
Intrahepatic Portosystemic Shunts - Assessing a New Surgical Technique for Treatment in Dogs
The purpose of this project is to assess the response to treatment of a relatively new treatment option (coil embolization) for intrahepatic portosystemic shunts, which has shown tremendous potential.
|
|
Clinical Trials that are "On Hold"
- Understanding the Genetics for Leopard Complex Spotting in Appaloosas
- Assessing a New Treatment for Oral Melanoma in Dogs
- Assessing a New Treatment for Lymphoma in Dogs
- Evaluating a New Formulation of Chemotherapy for Lymphoma in Dogs
- Understanding Intervertebral Disc Herniation in Dachshunds
- Identifying Lymph Node Metastasis in Dogs with Lung Tumors
- Assessing Minimally-Invasive Tumor Ablation in Cats and Dogs
- Improving Operative Detection of Tumors in Cats and Dogs
- Sentinel Lymph Node Mapping in Dogs
- Assessing a Potential Treatment for Mast Cell Tumors in Dogs
- Evaluating a Stem Cell Therapy for Inflammatory Bowel Disease
- Laser Ablation for Treatment of Ectopic Ureters in Dogs
- Stem Cell Therapy for Dogs with Acute Severe Spinal Cord Injury
NOTE: Trials that are "On Hold" are not accepting new patients and we do not know when these trials will open back up. If/when these trials do accept new patients again, we will notify you via this report and post information about the study (including contact information) on the VCCT website.
|
Clinical Trials that are Recently Completed or Finished Enrollment
- Understanding the Genetics Behind Addison's Disease in Nova Scotia Duck Tolling Retrievers
- Understanding the Genetics Behind Hypertrophic Osteodystrophy in Dogs
- Understanding the Genetics Behind Cleft Palates and Lips in Dogs
- Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs
- Finding a New Treatment for Pemphigus Foliaceus in Dogs
|
|
Thank you for wanting to be a part of our clinical trials program. We greatly appreciate your desire to participate in and inform others about our trials, and/or refer cases to the Veterinary Medical Teaching Hospital (VMTH). The VCCT and our clinical trials wouldn't be here without you!
|
|
Can't find what you are looking for? Got questions?
|
Interested in supporting the VCCT?
|
|
|
|
|
|
Copyright © 2017. All Rights Reserved.
|
|
|
|
