The RNA Transcript, December 7, 2020 |
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TODAY, Monday, December 7, 5:00–6:00 pm EST (note time change) | U-M Center for RNA Biomedicine RNA Innovation Seminar Series
"RNA at the epicenter of cell and developmental biology"
John Mattick, Ph.D., Professor of RNA Biology, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
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NSF Career Award
Aaron Frank, Chemistry and Biophysics, and former member of our Executive Committee, receives an NSF Career Award for his project "Constructing Multi-scale Dynamical Ensembles of Ribonucleic Acids (RNAs)." Congrats Dr. Frank!
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The Win-Win of Mentoring and Advising
Research shows that both faculty and students benefit when students are involved in effective mentoring and advising relationships.
The student is more productive in terms of research activity, conference presentations, predoctoral publications, instructional development, and grant-writing. The well-mentored students’ academic success is evident in higher completion rates and a shorter than average time to degree.
Faculty benefit in terms of both personal and professional satisfaction. As these students are more productive, faculty in turn attract better students, extend their professional network of future colleagues, and amplify their own success.
We’re thrilled to announce that Nils G. Walter, our very own co-director, received the 2020 Student’s Choice Faculty Mentor Award in recognition of outstanding mentorship in the Cellular & Molecular Biology Graduate Program, in the Medical School. Congrats Dr. Walter!
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Monday, December 7, 4:00–5:00 pm EST | U-M Chemistry
Parker is a member of the National Academy of Sciences and Howard Hughes Medical Investigator at the University of Colorado. His lab studies RNA regulation and decay using a variety of biochemical and biophysical approaches.
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Tuesday, December 8, 2020, 9:00 am EST | U-M Chemistry, Dissertation Defense
"Mechanism of Transcription and Translation Regulation by Riboswitches in Bacteria"
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Tuesday, December 8, 3:00 pm EST | Harvard Medical School
“Taming the Helix: The First 40 Years of RNA Therapeutics”
Tod Woolf, Ph.D., Executive Director, Technology Ventures Office, Beth Israel Deaconess Medical Center
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Thursday, December 10, 2020, 1:10–4:45 pm EST | U-M Complex Systems Presents: A Nobel Symposium (INFO)
University of Michigan faculty will discuss the work, impact, and personalities of the 2020 Nobel Laureates.
1:15–1:50: Nils G. Walter, co-director of the Center for RNA Biomedicine, will discuss the Chemistry Prize, CRISPR and RNA impact on biomedicine.
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Thursday, December 10, 2020, 2:00 pm EST | U-M Chemistry, Dissertation Defense
“To find and to form: Strategies for intracellular molecular target search and higher-order assembly”
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Friday, December 11, 2020, 9:00 am EST | U-M Chemical Biology, Dissertation Defense
“Understanding Transcription Through Structural Characterization of the CBP-p53 Transcriptional Coactivator-Activator Complex”
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Monday, December 14, 4:00–5:00 PM EST | U-M Center for RNA Biomedicine, RNA Innovation Seminar Series
"RNA-based regulation of viruses"
Narry Kim, Ph.D., Professor, School of Biological Sciences, Seoul National University Founding Director, RNA Research Center
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ZOOM TBA at https://www.rnasociety.org/rna-collaborative-seminar-series
“RNA regulates Glycolysis and Embryonic Stem Cell Differentiation via Enolase 1”
“Co-transcriptional RNP complex assembly in real-time: How transient protein-RNA interactions guide nascent ribosomal RNA folding”
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Wednesday, December 16 through Saturday, December 19 | IEEE BIBM 2020 Workshop on Long Non-Coding RNAs Mechanism, Function, and Computational Analysis (BIBM-LncRNA)
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January 6–8, 2021 | Intersections Science Fellows Symposium
This multi-institutional symposium will showcase the work of mid- to late stage postdocs in biomedical science on January 6-8th, 2021, virtually. This exciting symposium aims to showcase the science of outstanding postdocs specially those who are from backgrounds historically underrepresented in academia to advance diversity, equity and inclusion in academic science.
For more information, please visit our website and follow us on Twitter @InterSciFellows.
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Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below is a recent highlight.
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Broad noncoding transcription suggests genome surveillance by RNA polymerase V, Masayuki Tsuzuki, Shriya Sethuraman, Adriana N. Coke, M. Hafiz Rothi, Alan P. Boyle, and Andrzej T. Wierzbicki, Proceedings of the National Academy of Sciences of the U.S.A., first published November 16, 2020, doi.org/10.1073/pnas.2014419117
Significance
Eukaryotic genomes are pervasively transcribed, yet most transcribed sequences lack conservation or known biological functions. We show that a specialized plant-specific RNA polymerase V broadly transcribes the Arabidopsis genome. We propose a model where Pol V transcription surveils the genome and is required to recognize and repress newly inserted or reactivated transposons. Our results indicate that pervasive transcription of nonconserved sequences may serve an essential role in maintenance of genome integrity.
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UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer, Yajing Liu, Sahezeel Awadia, Amy Delaney, Merna Sitto, Carl G. Engelke, Heli Patel, Andrew Calcaterra, Sylvia Zelenka-Wang, Hojin Lee, Joseph Contessa, Nouri Neamati, Mats Ljungman, Theodore S. Lawrence, Meredith A. Morgan and Alnawaz Rehemtulla, Translational Oncology, 2020-11-01, Volume 13, Issue 11, Article 100834, Copyright © 2020 The Authors,
Significance
The UAE1 inhibitor TAK-243, mediates activation of the unfolded protein response, accumulation of DNA breaks and apoptosis, providing a rationale for the use as a safe and efficacious anti-cancer therapeutic for PDAC.
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