October 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and research metrics from the prior month. The gold colored buttons denote COVID-19 related publications. Brigham authors are bolded.

In September there were: 42 papers led by Brigham researchers published in top-tier journals 43 tweets about new research and 56.4K tweet impressions 4 press releases 4 research briefs 106 awards with $94,943,418 in new grants

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial. Spinner CD, Gottlieb RL, Criner GJ, Arribas López JR, Cattelan AM, [et al.] Marty FM; GS-US-540-5774 Investigators. JAMA. 2020 Sep 15;324(11):1048-1057. doi: 10.1001/jama.2020.16349.PMID: 32821939

Read the paper

Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us. Spagnolo PA, Manson JE, Joffe H. Ann Intern Med. 2020 Sep 1;173(5):385-386. doi: 10.7326/M20-1941. Epub 2020 May 8.PMID: 32384135

Read the paper

Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, [et al.] Anderson AC. Immunity. 2020 Sep 15;53(3):658-671.e6. doi: 10.1016/j.immuni.2020.08.005.PMID: 32937153

Read the paper

Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hypertension: a retrospective cohort study. Maron BA, Brittan EL, Hess E, Waldo SW, Barón AE, [et al.] Choudhary G. Lancet Respir Med. 2020 Sep;8(9):873-884. doi: 10.1016/S2213-2600(20)30317-9. Epub 2020 Jul 27.PMID: 32730752

Read the paper

Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors. Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Ann Intern Med. 2020 Sep 17:M20-5008. doi: 10.7326/M20-5008. Online ahead of print.PMID: 32941052

Read the paper

Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Jiang C, Lian X, Gao C, Sun X, Einkauf KB, [et al.] Yu XG. Nature. 2020 Sep;585(7824):261-267. doi: 10.1038/s41586-020-2651-8. Epub 2020 Aug 26.PMID: 32848246

Read the paper

Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial. Motzer RJ, Robbins PB, Powles T, Albiges L, Haanen JB, [et al.] Choueiri TK. Nat Med. 2020 Sep 7. doi: 10.1038/s41591-020-1044-8. Online ahead of print.PMID: 32895571

Read the paper

Neuropathological Features of Covid-19. Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, [et al.] Sabeti P. N Engl J Med. 2020 Sep 3;383(10):989-992. doi: 10.1056/NEJMc2019373. Epub 2020 Jun 12.PMID: 32530583 Free PMC article.

Read the paper

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes. Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, [et al.] McGuire DK; VERTIS CV Investigators. N Engl J Med. 2020 Oct 8;383(15):1425-1435. doi: 10.1056/NEJMoa2004967. Epub 2020 Sep 23.PMID: 32966714

Read the paper

Clinical Outcomes in Young US Adults Hospitalized With COVID-19. Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Rosenthal N, Solomon SD. JAMA Intern Med. 2020 Sep 9:e205313. doi: 10.1001/jamainternmed.2020.5313. Online ahead of print.PMID: 32902580

Read the paper

Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos. Xiong F, Ma W, Bénazéraf B, Mahadevan L, Pourquié O. Dev Cell. 2020 Sep 11:S1534-5807(20)30665-1. doi: 10.1016/j.devcel.2020.08.007. Online ahead of print.PMID: 32918876

Read the paper

Case 30-2020: A 54-Year-Old Man with Sudden Cardiac Arrest. Edelman ER, Butala NM, Avery LL, Lundquist AL, Dighe AS. N Engl J Med. 2020 Sep 24;383(13):1263-1275. doi: 10.1056/NEJMcpc2002420.PMID:

Read the paper

The New USMLE Step 1 Paradigm: An Opportunity to Cultivate Diversity of Excellence. Pershing S, Co JPT, Katznelson L. Acad Med. 2020 Sep;95(9):1325-1328. doi: 10.1097/ACM.0000000000003512.PMID: 32433311

Read the paper

Association of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection. Gopalakrishnan C, Bykov K, Fischer MA, Connolly JG, Gagne JJ, Fralick M. JAMA Intern Med. 2020 Sep 8:e204199. doi: 10.1001/jamainternmed.2020.4199. Online ahead of print.PMID: 32897307

Read the paper

Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset. Patorno E, Hernandez-Diaz S, Huybrechts KF, Desai RJ, Cohen JM, Mogun H, Bateman BT. PLoS Med. 2020 Sep 1;17(9):e1003322. doi: 10.1371/journal.pmed.1003322. eCollection 2020 Sep.PMID: 32870921

Read the paper

Medicaid Work Requirements In Arkansas: Two-Year Impacts On Coverage, Employment, And Affordability Of Care. Sommers BD, Chen L, Blendon RJ, Orav EJ, Epstein AM. Health Aff (Millwood). 2020 Sep;39(9):1522-1530. doi: 10.1377/hlthaff.2020.00538.PMID: 32897784

Read the paper

A shared genetic contribution to breast cancer and schizophrenia. Lu D, Song J, Lu Y, Fall K, Chen X, [et. al] Valdimarsdóttir UA. Nat Commun. 2020 Sep 15;11(1):4637. doi: 10.1038/s41467-020-18492-8.PMID: 32934226

Read the paper

Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts. García-Bayona L, Coyne MJ, Hantman N, Montero-Llopis P, Von SS, [et. al] Comstock LE. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24484-24493. doi: 10.1073/pnas.2009556117. Epub 2020 Sep 16.PMID: 32938803

Read the paper

The Lancet NCDI Poverty Commission: bridging a gap in universal health coverage for the poorest billion. Bukhman G, Mocumbi AO, Atun R, Becker AE, Bhutta Z, [et. al] Mayosi B; Lancet NCDI Poverty Commission Study Group. Lancet. 2020 Oct 3;396(10256):991-1044. doi: 10.1016/S0140-6736(20)31907-3. Epub 2020 Sep 14.PMID: 32941823

Read the paper

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, [et. al] Elledge SJ. Science. 2020 Sep 29:eabd4250. doi: 10.1126/science.abd4250. Online ahead of print.PMID: 32994364

Read the paper

COVID-19 Threatens Progress Toward Gender Equity Within Academic Medicine. Woitowich NC, Jain S, Arora VM, Joffe H. Acad Med. 2020 Sep 29:10.1097/ACM.0000000000003782. doi: 10.1097/ACM.0000000000003782. Online ahead of print.PMID: 33003040

Read the paper

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence. Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, [et. al] Simas JP. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22443-22451. doi: 10.1073/pnas.2004809117. Epub 2020 Aug 20.PMID: 32820070

Read the paper

Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial. Mittendorf EA, Zhang H, Barrios CH, Saji S, Jung KH, [et. al] Harbeck N. Lancet. 2020 Oct 10;396(10257):1090-1100. doi: 10.1016/S0140-6736(20)31953-X. Epub 2020 Sep 20.PMID: 32966830

Read the paper

Human γδ T cells recognize CD1b by two distinct mechanisms. Reijneveld JF, Ocampo TA, Shahine A, Gully BS, Vantourout P, [et. al] Van Rhijn I. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22944-22952. doi: 10.1073/pnas.2010545117. Epub 2020 Aug 31.PMID: 32868441

Read the paper

Does adherence to evidence-based practices during childbirth prevent perinatal mortality? A post-hoc analysis of 3,274 births in Uttar Pradesh, India. Semrau KE, Miller KA, Lipsitz S, Fisher-Bowman J, Karlage A, [et. al] Gawande AA. BMJ Glob Health. 2020 Sep;5(9):e002268. doi: 10.1136/bmjgh-2019-002268.PMID: 32928798

Read the paper

The Fragility Index and Trial Significance. Chaitoff A, Zheutlin A, Niforatos JD. JAMA Intern Med. 2020 Sep 21. doi: 10.1001/jamainternmed.2020.4787. Online ahead of print.PMID: 32955584 No

Read the paper

Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis. Burke CA, Dekker E, Lynch P, Samadder NJ, Balaguer F, [et. al] Cohen A. N Engl J Med. 2020 Sep 10;383(11):1028-1039. doi: 10.1056/NEJMoa1916063.PMID: 32905675 Clinical Trial.

Read the paper

Progress in Cancer Research, Prevention, and Care. Schilsky RL, Nass S, Le Beau MM, Benz EJ Jr. N Engl J Med. 2020 Sep 3;383(10):897-900. doi: 10.1056/NEJMp2007839.PMID: 32877579

Read the paper

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect. Bachireddy P, Ennis C, Nguyen VN, Gohil SH, Clement K, [et. al] Wu CJ. Sci Transl Med. 2020 Sep 16;12(561):eabb7661. doi: 10.1126/scitranslmed.abb7661.PMID: 32938797

Read the paper

US Spending Associated With Transition From Daily to 3-Times-Weekly Glatiramer Acetate. Rome BN, Tessema FA, Kesselheim AS. JAMA Intern Med. 2020 Sep 1;180(9):1165-1172. doi: 10.1001/jamainternmed.2020.2771.PMID: 32897384

Read the paper

NRP1 cripples immunological memory. Acharya N, Anderson AC. Nat Immunol. 2020 Sep;21(9):972-973. doi: 10.1038/s41590-020-0759-5.PMID: 32724188

Read the paper

Deep Learning Using Chest Radiographs to Identify High-Risk Smokers for Lung Cancer Screening Computed Tomography: Development and Validation of a Prediction Model. Lu MT, Raghu VK, Mayrhofer T, Aerts HJWL, Hoffmann U. Ann Intern Med. 2020 Sep 1. doi: 10.7326/M20-1868. Online ahead of print.PMID: 32866413

Read the paper

Potential Adverse Financial Implications of the Merit-based Incentive Payment System for Independent and Safety Net Practices. Colla CH, Ajayi T, Bitton A. JAMA. 2020 Sep 8;324(10):948-950. doi: 10.1001/jama.2020.13093.PMID: 32897331

Read the paper

Sewing Masks - Resilience in the Face of Covid. Rittenberg E. N Engl J Med. 2020 Sep 30. doi: 10.1056/NEJMp2019830. Online ahead of print.PMID: 32997902

Read the paper

Time Out Before Talking: Communication as a Medical Procedure. Lakin JR, Tulsky JA, Bernacki RE. Ann Intern Med. 2020 Sep 8. doi: 10.7326/M20-4223. Epub ahead of print. PMID: 32894694.

Read the paper

Up Is Down - Pharmaceutical Industry Caution vs. Federal Acceleration of Covid-19 Vaccine Approval. Avorn J, Kesselheim AS. N Engl J Med. 2020 Sep 15. doi: 10.1056/NEJMp2029479. Online ahead of print.PMID: 32931162

Read the paper

Building an Evidence Base for Survivors of Critical Illness. Lamas D. N Engl J Med. 2020 Sep 10;383(11):1067-1068. doi: 10.1056/NEJMe2024625.PMID: 32905682

Read the paper

Timing of radiotherapy after radical prostatectomy. Tilki D, D'Amico AV. Lancet. 2020 Sep 28:S0140-6736(20)31957-7. doi: 10.1016/S0140-6736(20)31957-7. Online ahead of print.PMID: 33002430

Read the paper

Patient Safety and Resident Schedules without 24-Hour Shifts. Reply. Landrigan CP, Rahman SA, Czeisler CA. N Engl J Med. 2020 Sep 24;383(13):1288. doi: 10.1056/NEJMc2025843.PMID: 32966732

Read the paper

Invasive or Conservative Strategy for Stable Coronary Disease. Reply. Antman EM, Braunwald E. N Engl J Med. 2020 Sep 3;383(10):e66. doi: 10.1056/NEJMc2024008.PMID: 32877597

Read the paper

From Icebox to Tinderbox - A View from the Southern Border. Cuneo CN, Janeway H. N Engl J Med. 2020 Sep 24;383(13):e81. doi: 10.1056/NEJMp2009985. Epub 2020 Aug 5.PMID: 32757518

Read the paper

Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma De Rienzo A, Chirieac LR, Hung YP, Severson DT, Freyaldenhoven S, [et. al] Richards WG. J Pathol. 2020 Sep 17. doi: 10.1002/path.5551. Epub ahead of print. PMID: 32944962.

Read the paper

**Please visit the new MGB web page for COVID funding opportunities that provides a central database for researchers to view open and competitive funding announcements***

Questions, comments, or concerns? Please reach out to our Research Helpline ResearchHelpline@bwh.harvard.edu with any and all of your research related inquiries!