SCIENCE ALERT: Salidroside from Rhodiola effects gut microbiota and liver injury in mouse model (Food Chem Toxicol)

Editor's Note

This study investigates the ameliorative effect of salidroside (SAL) from Rhodiola Rosea L. on the intestinal microflora subject to furan-induced liver injury in a mouse model . The authors found that SAL supplement restrained intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan. The study concludes that SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases.

March 2019

Food and Chemical Toxicology

DOI: https://doi.org/10.1016/j.fct.2019.01.007

Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model

In our study, the ameliorative effect of salidroside (SAL) from Rhodiola Rosea L. on the intestinal microflora subject to furan-induced liver injury in a mouse model was investigated by 16 S rDNA , oxidative indexes, LPS and cytokine levels. The results demonstrated that SAL alleviated hepatic oxidative injury by inhibiting the activities of AST, ALT and the content of MDA , and promoting the activities of SOD, GSH and GST, compared to the furan-treated group. SAL significantly modified the intestinal microbial diversity and downregulated the circulating levels of serum LPS, IL-6, and TNF-α , as well as enhanced the content of IL-10. Importantly, SAL dramatically increased LPS-suppressing bacteria genera Akkermansia, and decreased LPS-producing bacteria phyla Proteobacteria . Our results indicate that SAL supplement restrains intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan . Hopefully, SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases.