Non-exempt IRB protocols approved under the pre-2019 Common Rule (a.k.a. “old rule”) may continue through completion under the old rule (i.e., be “grandfathered in”) provided the investigator maintains continuous approval by submitting his/her continuing review information in a timely manner before the approval expiration date. Investigators are sent multiple reminders for continuation review in advance of the approval expiration date; the first being 3 months prior to expiration. If the approval lapses, the protocol can no longer remain open and must be closed.  If the research needs to continue past the expiration of approval, all research activities must cease and a brand new application must be submitted and approved under the revised, 2019 Common Rule (a.k.a. “current rule”) . If needing to submit a new protocol due to the expiration of approval on a Pre-2019 protocol, contact ORI staff to ascertain the recommended review type for the new application.