Anesthesiology, Perioperative & Pain Management - BWH
Ready, Set,
July 9, 2020 | 8.0
Dear Colleagues, 

A big thank-you to everyone who helped out in the last three months to bring us through all the phases of COVID-19, from the surge preparation and closure of labs, to the actual surge, and now the reimagining phase. Our investigators really stepped up by working clinically, transitioning on the fly to perform COVID research, transitioning large labs to 100% remote work while continuing to write grants/publications, and now performing research in ways we would never have imagined previously. 

By now, most of you are likely adjusted to our new normal in your respective labs and roles, restarting your research and trying to make up for lost time. If you have not had a chance to submit this mandatory “return to onsite clinical research plan,” please do so at this redcap survey link. 

In this newsletter we are presenting a number of awards, research highlights, and this month’s featured investigator. We also want to announce our 2020 internal funding - the BWH Anesthesia Basic Science Grant, the BWH Anesthesia Basic/Clinical translational Collaborator Grant, and as our ongoing seed grants (more info can be found below).  

Please let us know if you have any questions or concerns as we go into these uncharted waters. 

Best,
Danny & the entire research team 
Awards & Grants
Michaela Farber, MD, MS
Michaela Farber was awarded a two-year CRICO Patient Safety Grant for her project entitled “Development of an Integrated, Technology-Based Approach to Postpartum Hemorrhage Risk Assessment and Management to Optimize Maternal Safety”. As the recipient of the BWH Anesthesia Starter Grant in 2019, we are particularly excited that Dr. Farber was able to leverage her internal award for external funding!
Brian Bateman, MD, MSc
Brian Bateman was awarded a four-year R01 from the National Institute for Drug Abuse entitled “The Comparative Effectiveness and Safety of Pharmacotherapies for the Treatment of Opioid Use Disorder in Pregnancy”. The study will use advanced epidemiological methods applied to data from Medicaid patients to provide robust evidence on the effects of available pharmacotherapies to treat OUD during pregnancy.
Danny Muehlschlegel, MD, MSc
Danny Muehlschlegel received a five-year R01 from the National Institute of Health entitled “Cardiac Exosomes in Myocardial Ischemic Injury” which will define the link between genetic variation, altered non-coding RNA expression and myocardial injury in human myocardial tissue and its associated RNA peripheral biomarkers. These RNA biomarkers can have an immediate clinical impact and advance the biological understanding, diagnosis and therapy of myocardial injury in humans.
Mihaela Podovei, MD
Michaela Podovei received a Healthcare Quality and Patient Safety Fellowship supported by a CRICO grant from BI that starts on 07/01.
Matt Spite, PhD
Matt Spite received two sub-contract awards from the NIH that started 04/01, one from John Hopkins University and the other from Joslin Diabetes Clinic.
Gyorgy Frendl, MD, PhD
George Frendl received a COVID-19 award from Iqvia Ros Inc. 05/04/2020.
Omid Farokhzad, MD
Dr. Farokhzad received a Stepping Strong Breakthrough Award.
Linda S. Aglio MD, MS 
Linda Aglio received an award from the BWH Program in Interdisciplinary Neuroscience – Women’s Brain Initiative entitled “Digital phenotyping to monitor a CBT pain intervention for women undergoing surgery.” She will utilize passive and active data to monitor a Cognitive Behavioral Therapy (CBT) pain prevention intervention for women undergoing elective spine surgery.
Featured Investigator Interview
Vesela Kovacheva, MD, PhD
Dr. Vesela P. Kovacheva, MD, PhD is an Assistant Professor of Anesthesiology at Harvard Medical School. She was born in Sofia, Bulgaria and from a very early age had an insatiable appetite for nature. She loved insects, mammals, plants and has always been interested in science and the development of life. Her mother, a professor of economics, was a role model who always encouraged her interests and would read to her many books about science during her childhood, learning about Louis Pasteur and his experiments as well as many other scientists. 

Dr. Kovacheva 's love of science never ceased. She was accepted into the National High School of Nature and Mathematics, which was affiliated with the University of Sofia and most of the teachers there were professors from the university. During her high school years, the emphasis was on sciences, math, biology and physics. She was excited about biotechnology. While in high school, she published her first two articles in the Bulgarian peer-reviewed journal, Nature and Knowledge. She was accepted into the University of Sofia specialty ‘Molecular Biology,’ without having to take any entrance examinations. At the last minute, right before graduating high school, she decided to go to medical school. During her training to become a physician, she continued with research, completing a project about changes in the brain during chronic opioid use. 

After graduating from the Medical University of Sofia, she followed her passion in research and was accepted into a PhD program at Boston University. She majored in Neuroscience, focusing on maternal nutrition during pregnancy in rats and its’ affect on brain development and risk of breast cancer. This research has been cited over 100 times.  

Dr. Kovacheva then went on to do a medical internship at the Berkshire Medical Center followed by anesthesiology residency, and fellowship in obstetric anesthesiology at Brigham and Women’s Hospital. 

It was during her rotation in obstetric anesthesiology that she found a true passion for her current research and clinical work. She attributes her continued support and mentorship by Dr. Lawrence Tsen and, more recently, Drs. Brian Bateman, Richa Saxena and Kathryn Gray as a pivotal experience, helping her succeed in her current work, focusing on using Big Data to advance and personalize the care of the pregnant patients. In one of her projects, she uses genetic information obtained from patients throughout the world who have suffered from postpartum hemorrhage, to better understand the mechanisms that lead to this life-threatening condition. In another project, she is using artificial intelligence to automate drug infusions in a closed-loop system. She attributes her success to her wonderful research team and colleagues, abundant resources and funding from the Foundation for Anesthesia Education and Research, Brigham Research Institute and Partners Innovation.  

Along with her work in OB, Dr. Kovacheva has made many contributions to clinical research in the main OR and continues to be a team player in many projects. She also encourages others to participate and to follow their true passions. 

Outside of her work she has two adorable daughters: Kalina (six years old) and Dara, (three years old). She enjoys spending time with them exploring nature, riding scooters and cooking. Her love of Bulgarian food is apparent and she describes wonderfully tasty, healthy recipes that she prepares from scratch; dishes cooked in ‘giuveche’, traditional Bulgarian clay pots, stuffed peppers with rice and vegetables, and deserts like ‘banitza’, a fruit and cheese filo dough pie. In addition to her cooking and children she has a love for the arts. She loves modern art and enjoys the works of Jenny Holzer, Eduardo Kac and Banksy. Her favorite painter is the Dutch artist Vermeer. Her favorite painting is The Mistress and the Maid, she loves the colors.
ORC Grant Central: "Write Winning NIH Grant Proposals" and
"Write Winning NIH Career Development Grant Proposals" 
Tuesday, July 28 - Thursday, July 30, 1:00 - 4:30pm, Zoom 
Deadline to register: July 15th 
Join the BWH Office for Research Careers (ORC) to learn how to craft winning NIH grant proposals in this three half-day virtual seminar series led by Dr. John D. Robertson of Grant Writers' Seminars and Workshops. Open to all faculty with a primary appointment at BWH.

Email questions to  BWHORC@partners.org.
Register here
Here are the results of the IntubateCOVID study many in the Department participated in as probands.
READ: Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study
Research Highlights
Chris Connor, MD, PhD

Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia
Charles Serhan, PhD, DSc

Resolving Inflammation

Video of two lectures: The first video is by a surgeon, Dr. Martindale, who builds a beautiful bridge between discoveries of our own Dr. Charlie Serhan and the clinical arena. This lecture describes steps in the promising direction of translational research on resolution of inflammation. The second lecture is by Dr. Serhan on the basics of his discoveries.
Bryan Davis, MD & Lawrence Tsen, MD

Wearing an N95 Respiratory Mask: An Unintended Exercise Benefit?
Finding Funding
Are you considering submitting a grant?
Please reach out to Rachel Abrams for a list of required documents and to get the process started.
Featured Opportunities
MGB Collaborative Grant Application
Details: https://covidinnovation.partners.org/funding/

BWH Anesthesia Department Basic Science Starter Grant
With the goal of supporting an investigator dedicated to basic science research that will lead to competitive application for extramural funding.  
Deadline : Letters of intent are due 8/15/20 , invited applications are due 9/30/20
Funding : $50,000 plus investigator time, two/year
Eligibility :
  • Lecturer, Instructor, Assistant, or Associate Professor at the time of award funding
  • MD or PhD or equivalent degree
  • Grants will be judged by the Research Leadership Committee and external reviewers
More information here

BWH Anesthesia Department Basic/Clinical Collaborator Grant
The goal of this grant is to encourage collaboration between a basic and a clinical/translational scientist within our department that will lead to competitive application for extramural funding.
Deadline : Letters of intent are due 8/15/20 , invited applications are due 9/30/20
Funding : Up to $50,000
Eligibility :
  • All levels from Lecturer to Professor are eligible to apply
  • MD or PhD or equivalent degree
  • Grants will be judged by the Research Leadership Committee and external reviewers.
More information here

McGraw Family Opioid Innovator Awards 
Deadline : Letters of intent are due on 7/22/20 & RFAs are due on 9/11/20
Funding : ONE $50,000 award & ONE $25,000 award 
Eligibility :  See RFA details
The McGraw Family Innovator Awards (open specifically to opioid-related research). These awards aim to advance projects that have the potential to make an impact in one or more of the following domains: biomedical research, healthcare delivery, the generation of new companies/products/services, cost savings, care quality and provider burnout among others.
For more information, contact Gloria Brand, MPA .
Apply here

RFA for the Grants for Early Medical/Surgical Specialists' Transition to Aging Research
(GEMSSTAR)
Deadline : 11/13/20 for May Council 2021
Funding : $100,000 for direct costs per year for two years
Eligibility : The GEMSSTAR award is targeted to early faculty members who have recently completed their medical, surgical, or dental training in any specialty or discipline and are embarking on a career in clinical aging research in their specialty area. The award is intended to offer support in a particularly vulnerable time in a new clinical faculty member’s career.
Applicants can direct inquiries to the GEMSSTAR email niagemsstar@mail.nih.gov or consult the GEMSSTAR FAQ Website .
BRI Microgrants
Amount: $500 - $1,000
Deadline: Applications accepted on a rolling basis
Application Here

Anesthesiology Department Seed Funding
Deadline : Rolling
Funding : up to $10,000 
Eligibility : Lecturer, Instructor, Assistant, or Associate Professor at the time of award funding
•   Goal: Support clinical, translational, or basic science research and project development
•   Prerequisites: 
–   Grantee should have a mentoring plan (senior mentor or mentoring team in area of proposed investigation)
–   Grantee should have a career development plan
Up to five seed grants will be awarded in 2020 . Grant recipients are required to present their work to the Research Leadership Committee before the start of the project and to the Department at the conclusion of their grant.
Helpful Resources
For guidance and advice on the research process and resources, contact Sarah Corey.

For a Department of Anesthesiology Biostatistical consult, please follow this link or send an email to Kara Fields.
Partners Pulse Login Page for access to training/learning modules
Perioperative Data Group
(requires Partners login to access)
Research Navigator Login Page
Committee on Human Research (IRB) resources
(requires Navigator login to access)
Publications
Rates and Costs of Dispensing Naloxone to Patients at High Risk for Opioid Overdose in the United States, 2014-2018.  
Barenie RE, Gagne JJ, Kesselheim AS, Pawar A, Tong A, Luo J,  Bateman BT  
Drug Saf. 2020 Jul;43(7):669-675. doi: 10.1007/s40264-020-00923-6.PMID:32180134 
 
Can enhanced recovery protocols impact non-opioid multimodal analgesia use in all surgical patients?  
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 Jun 26;66:109963. doi: 10.1016/j.jclinane.2020.109963. Online ahead of print.  PMID:32599510  
 
Erector Spinae Plane Block (ESPB) or Quadratus Lumborum Block (QLB-II) for laparoscopic cholecystectomy: Impact on postoperative analgesia.  
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 Jun 17;66:109958. doi: 10.1016/j.jclinane.2020.109958. Online ahead of print.  PMID:32563073  
 
Myeloid ALX/FPR2 regulates vascularization following tissue injury.  
Sansbury BE ,  Li X,   Wong B , Patsalos A, Giannakis N, Zhang MJ, Nagy L, Spite M. 
Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14354-14364. doi: 10.1073/pnas.1918163117. Epub 2020 Jun 8.  PMID:32513697 
 
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?  
Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP,  Serhan CN , Hammock BD. 
Cancer Metastasis Rev. 2020 Jun;39(2):337-340. doi: 10.1007/s10555-020-09889-4.  PMID: 32385712 
 
Advances in Value-Based Healthcare by the Application of Time-Driven Activity-Based Costing for Inpatient Management: A Systematic Review.  
Etges APBDS, Ruschel KB, Polanczyk CA,  Urman RD . 
Value Health. 2020 Jun;23(6):812-823. doi: 10.1016/j.jval.2020.02.004. Epub 2020 May 26.  PMID:  32540239 Review. 
 
COVID-19: Recommendations for regional anesthesia.  
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 May 20;65:109885. doi: 10.1016/j.jclinane.2020.109885. Online ahead of print.  PMID:32454343. 
 
Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study.  
Zhu Y,  Bateman BT , Gray KJ, Hernandez-Diaz S, Mogun H, Straub L, Huybrechts KF. 
BMJ. 2020 May 20;369:m1494. doi: 10.1136/bmj.m1494.  PMID: 32434758 
 
Using a pre-procedure COVID-19 huddle to improve operating room safety.  
Pimentel MPT , Pimentel CB, Wheeler K, Dehmer E,  Vacanti JC,   Urman RD . 
J Clin Anesth. 2020 May 19;65:109875. doi: 10.1016/j.jclinane.2020.109875. Online ahead of print.  PMID:32450475. 
 
A comparison of difficult intubation documentation practices with existing guidelines in the advent of video laryngoscopy.  
Kauffman MB , Liu J,  Urman RD ,  Fields KG ,  Yao D . 
J Clin Anesth. 2020 May 12;65:109807. doi: 10.1016/j.jclinane.2020.109807. Online ahead of print.  PMID:32413813 
 
COVID-19: Obstetric anesthesia care considerations. 
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 May 11;65:109860. doi: 10.1016/j.jclinane.2020.109860. Online ahead of print.  PMID: 32417620  
 
To improve quality, keep your eyes on the road. 
Pimentel MPT , Austin JM, Kachalia A. 
BMJ Qual Saf. 2020 May 11:bmjqs-2020-011102. doi: 10.1136/bmjqs-2020-011102. Online ahead of print.  PMID: 32393598 Review. 
 
Recommendations for Managing Opioid-Tolerant Surgical Patients within Enhanced Recovery Pathways. 
Stone A , Roberts A, de Boer HD, Kaye AD, Fawcett WJ,  Urman RD . 
Curr Pain Headache Rep. 2020 May 8;24(6):28. doi: 10.1007/s11916-020-00856-w. 
PMID: 32385525 Review. 
 
COVID-19: Anesthesia Management Recommendations. 
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 Apr 23:109840. doi: 10.1016/j.jclinane.2020.109840. Online ahead of print. 
PMID: 32362425. 
 
The Effect of Regional Anesthesia on Outcomes After Minimally Invasive Ivor Lewis Esophagectomy. 
Tankard KA , Brovman EY, Allen K,  Urman RD . 
J Cardiothorac Vasc Anesth. 2020 Apr 19:S1053-0770(20)30288-3. doi: 10.1053/j.jvca.2020.03.039. Online ahead of print.  PMID: 32418834 
 
Is posteromedial quadratus lumborum block better than lateral transversus abdominis plane block for laparoscopic colorectal surgery? 
Khalil MM,  Urman RD , Said ET, Gabriel RA. 
J Clin Anesth. 2020 Apr 17;64:109823. doi: 10.1016/j.jclinane.2020.109823. Online ahead of print.  PMID: 32315942. 
 
Perioperative Point of Care Ultrasound (POCUS) for Anesthesiologists: an Overview. 
Li L ,  Yong RJ , Kaye AD,  Urman RD . 
Curr Pain Headache Rep. 2020 Mar 21;24(5):20. doi: 10.1007/s11916-020-0847-0. 
PMID: 32200432 Review. 
 
Is there evidence to recommend a "cutoff" BMI for day-case eligible orthopedic surgery? 
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 Aug;63:109776. doi: 10.1016/j.jclinane.2020.109776. Epub 2020 Mar 13. 
PMID: 32178851 
 
Understanding the patterns of injuries related to endotracheal intubation. 
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 Aug;63:109752. doi: 10.1016/j.jclinane.2020.109752. Epub 2020 Mar 5. 
PMID: 32147215  
 
Thrombocytopenia and neuraxial anesthesia: Are there platelet count thresholds? 
Herman JA, Urits I, Kaye AD,  Urman RD , Viswanath O. 
J Clin Anesth. 2020 Aug;63:109751. doi: 10.1016/j.jclinane.2020.109751. Epub 2020 Mar 4. 
PMID: 32145501  
 
Synergistic effect of perineural dexamethasone and dexmedetomidine (Dex-Dex) in extending the analgesic duration of a transversus abdominis plane block. 
Herman J, Urits I,  Urman RD , Kaye AD, Viswanath O, Eskander JP. 
J Clin Anesth. 2020 Aug;63:109750. doi: 10.1016/j.jclinane.2020.109750. Epub 2020 Feb 25. 
PMID: 32109826. 
 
Minimally Invasive Lumbar Decompression and Interspinous Process Device for the Management of Symptomatic Lumbar Spinal Stenosis: a Literature Review. 
Merkow J , Varhabhatla N, Manchikanti L, Kaye AD,  Urman RD ,  Yong RJ . 
Curr Pain Headache Rep. 2020 Feb 18;24(4):13. doi: 10.1007/s11916-020-0845-2.  PMID: 32072362 Review. 
 
Patient and Surgery-Related Predictors of Acute Postoperative Pain. 
Coppes OJM ,  Yong RJ , Kaye AD,  Urman RD . 
Curr Pain Headache Rep. 2020 Feb 18;24(4):12. doi: 10.1007/s11916-020-0844-3.  PMID: 32072315 Review. 
 
Do quantitative blood loss measurements and postpartum hemorrhage protocols actually make a difference? Yes, no, and maybe. 
Chau A,  Farber MK . 
Int J Obstet Anesth. 2020 May;42:1-3. doi: 10.1016/j.ijoa.2020.02.001. Epub 2020 Feb 12.  PMID: 32165087  
 
Rapid in-person cognitive screening in the preoperative setting: Test considerations and recommendations from the Society for Perioperative Assessment and Quality Improvement (SPAQI). 
Arias F, Wiggins M,  Urman RD , Armstrong R, Pfeifer K,  Bader AM , Libon DJ, Chopra A, Price CC. 
J Clin Anesth. 2020 Jun;62:109724. doi: 10.1016/j.jclinane.2020.109724. Epub 2020 Feb 1.  PMID: 32018131 Review. 
 
A prospective, randomized comparison of ultrasonographic visualization of proximal intercostal block vs paravertebral block. 
Vlassakov K ,  Vafai A,   Ende D ,  Patton ME ,  Kapoor S ,  Chowdhury A ,  Macias A ,  Zeballos J, Janfaza DR ,  Pentakota S ,  Schreiber KL . 
BMC Anesthesiol. 2020 Jan 9;20(1):13. doi: 10.1186/s12871-020-0929-x.  PMID: 31918668 
 
Gone in the blink of an eye - A Tolosa-Hunt syndrome variant. 
Dholoo F, Shabana A,  Paschali M , Mandal AKJ, Missouris CG. 
J Clin Neurosci. 2020 Feb;72:458-460. doi: 10.1016/j.jocn.2019.12.037. Epub 2019 Dec 24.  PMID: 31879056 
 
Author Correction: Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation. 
Norris PC , Skulas-Ray AC,  Riley I , Richter CK, Kris-Etherton PM, Jensen GL,  Serhan CN , Maddipati KR. 
Sci Rep. 2019 Dec 19;9(1):19816. doi: 10.1038/s41598-019-56282-5.  PMID: 31852986 
 
Risk factors and associated complications of acute kidney injury in adult patients undergoing a craniotomy. 
Chung S , Brovman EY,  Aglio LS ,  Beutler SS ,  Urman RD . 
Clin Neurol Neurosurg. 2020 Mar;190:105642. doi: 10.1016/j.clineuro.2019.105642. Epub 2019 Dec 16.  PMID: 31881416 
 
A closed claims analysis of vocal cord injuries related to endotracheal intubation between 2004 and 2015. 
Homsi JT ,  Brovman EY , Greenberg P,  Urman RD . 
J Clin Anesth. 2020 May;61:109687. doi: 10.1016/j.jclinane.2019.109687. Epub 2019 Dec 10. PMID: 31836265 
 
Addressing Racial and Ethnic Disparities in Pain Management in the Midst of the Opioid Crisis. 
Bateman BT , Carvalho B. 
Obstet Gynecol. 2019 Dec;134(6):1144-1146. doi: 10.1097/AOG.0000000000003590.  PMID: 31764722. 
 
Use of an erector spinae plane block for perioperative pain control in coronary artery bypass graft surgery. 
Schwartz RH, Urits I, Viswanath O,  Urman RD , Kaye AD, Eskander JP. 
J Clin Anesth. 2020 May;61:109652. doi: 10.1016/j.jclinane.2019.109652. Epub 2019 Nov 29.  PMID: 31787494. 
 
Risk factors and reasons for reoperation after radical cystectomy. 
Reese SW, Ji E, Paciotti M, Leow JJ, Mahvi DA, Steele G,  Urman RD , Whang EE, Kibel AS, Mossanen M. 
Urol Oncol. 2020 Apr;38(4):269-277. doi: 10.1016/j.urolonc.2019.10.011. Epub 2019 Nov 22.  PMID: 31761610 
 
In Response. 
Urman RD , Chung F, Gan TJ. 
Anesth Analg. 2019 Oct 31. doi: 10.1213/ANE.0000000000004504. Online ahead of print.  PMID: 31688082. 
 
The Association Between Potential Opioid-Related Adverse Drug Events and Outcomes in Total Knee Arthroplasty: A Retrospective Study. 
Jones MR,  Kramer ME ,  Beutler SS , Kaye AD, Rao N,  Brovman EY ,  Urman RD . 
Adv Ther. 2020 Jan;37(1):200-212. doi: 10.1007/s12325-019-01122-1. Epub 2019 Oct 29.  PMID: 31664696 
 
Potential opioid-related adverse events following spine surgery in elderly patients. 
Jones MR,  Brovman EY , Novitch MB, Rao N,  Urman RD . 
Clin Neurol Neurosurg. 2019 Nov;186:105550. doi: 10.1016/j.clineuro.2019.105550. Epub 2019 Oct 3.  PMID: 31610320 
 
Newer nerve blocks in pediatric surgery. 
Kaye AD, Green JB, Davidson KS, Gennuso SA, Brown ML, Pinner AM, Renschler JS, Cramer KD, Kaye RJ, Cornett EM, Helmstetter JA,  Urman RD , Fox CJ. 
Best Pract Res Clin Anaesthesiol. 2019 Dec;33(4):447-463. doi: 10.1016/j.bpa.2019.06.006. Epub 2019 Sep 20.  PMID: 31791563 Review. 
 
Academic Interest in Pain: Comparison of Four Specialties With Long-Standing Involvement in Pain Medicine. 
Correll DJ ,  Kissin I . 
J Anesth Hist. 2020 Jun;6(2):84-89. doi: 10.1016/j.janh.2019.08.003. Epub 2019 Sep 6.  PMID: 32593382 
 
Overnight call and sleep deprivation - A demand for action. 
Tsai MH,  Urman RD , Adams DC. 
J Clin Anesth. 2020 Mar;60:74-75. doi: 10.1016/j.jclinane.2019.08.046. Epub 2019 Aug 29.  PMID: 31473448 
 
Pulmonary thromboembolism from extracorporeal life support (ECLS) cannula-associated Thrombus. 
Elhassan A, Dimitrova GT,  Urman RD , Cornett EM, Kaye AD. 
J Clin Anesth. 2020 Mar;60:6-7. doi: 10.1016/j.jclinane.2019.08.002. Epub 2019 Aug 17.  PMID: 31430646  
 
Awal MR, Wirak GS, Gabel CV,  Connor CW .  Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia .  Anesthesiology . 2020;133(1):133-144. doi:10.1097/ALN.0000000000003304 
If you have important information, an update, or announcement that you would like to include in next month's research newsletter, please email your content along with any images, to Sarah Corey .