Antitissue transglutaminase (atTG) normalization post-diagnosis in children with Celiac Disease (CD)
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A retrospective chart review of 487 children diagnosed with CD, evaluated Marsh Score (used to classify the extent of villus damage ), gluten-free diet compliance (GFDC) and many other factors, on normalization of atTG in children with CD.
Median time to normalization of atTG levels appears to be 407 days (for all CD diagnosed children) and 364 days for those who are gluten-free diet compliant (GFDC).
In CD children, GFDC and a lower atTG at diagnosis are predictors of earlier normalization.
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Long-term renal function in survivors of childhood Wilms Tumor (WT)
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A 24.8 year follow-up of WT survivors treated with a combination of surgery, chemotherapy, and radiotherapy indicates that 55.9% have aged-adjusted below normal GFR, 13.5% have albuminuria, 83.3% have compensated contralateral renal hypertrophy and 40.5% arterial hypertension.
"WT survivors appear to have significant unidentified subclinical signs of renal function impairment and secondary morbidity". Regular follow-up into adulthood is required.
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Utility of lumbar puncture (LP) in children presenting with Status Epilepticus (SE)
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As infectious organisms causing meningitis may present with seizures, a retrospective study of 126 children (1 month to 12 years of age ) who presented to an emergency department with first time SE and who had a LP performed, investigated the presence of bacterial or viral meningitis.
It appears that SE as a presentation of bacterial or viral meningitis occurs uncommonly (0.8% and 5% respectively).
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Prevalence of preoperative penile abnormalities prior to circumcision in a developing community
While neonatal circumcision is common in many communities, adolescent circumcision is uncommon except in areas of high HIV transmission where it has been found to be an effective strategy to lower HIV transmission rates.
From a countrywide (Southern Africa) male circumcision program of 929 males (ages 6-19 years), preoperative genital medical conditions and penile abnormalities were noted. Many (83%) have at least one pre-existing penile abnormality detected: phimosis, adherent foreskin and hypospadias.
In developing communities neonatal circumcision may identify/decrease many of the abnormalities/complications seen in those remaining uncircumcised.
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Homemade zip line injuries in children
"Playground track rides and homemade zip line-related injuries are increasingly seen in the emergency department".
A study examined data from 9,397 children (0-17 years of age) with zip line-related injuries (45.9% homemade, 54.1% playground). From falls predominantly, injuries include; fractures (49.8%), contusion/lacerations (21.2%), and head injuries (12.7%).
"Homemade zip lines injuries are increasing. Children 5 to 9 years are at particular risk and should be carefully supervised".
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Video Feature
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Ziplining Injuries on the Rise
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Long-term follow-up of neonatal brachial plexopathy: Psychological and physical function in adolescents and young adults
A long-term study of 31 adolescents (16-18 years) and 25 young adults (23-28 years) who had neonatal brachial plexus palsy (NBPP) investigated psychological, health, quality of life plus functional ability - educational attainment (and other parameters).
Infants with NBPP appear to adapt and participate in most activities in spite of persistent functional limitations and high rates of obesity. They function psychologically and cognitively within the normal range and many achieve higher educational status.
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The role of social-cognitive and emotional factors on exclusive breastfeeding duration
From a one-group, self-report survey of 375 mothers who rated social-cognitive variables towards breastfeeding, it appears that breastfeeding duration may be positively predicted by self-efficacy, pride and regret but negatively predicted by the fear of poor infant nutrition.
Social/cognitive variables play a role in both the onset and duration of breastfeeding and should be considered when advising mothers towards exclusive breastfeeding.
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October Patient of the Month: Mariana
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Take the Quiz
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What are absence seizures?
Can you define and describe non-celiac gluten sensitivity?
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