Wall Street Rides FAR Kicks Off 2017 Ride with Happy Hour
 
ASF supporter Paul Morris (right) with his mother, Robin Morris (left), from Ride FAR Team Paulie's Promise.
Click here to read Paul's piece, "Why I Ride."
ASF has officially kicked off its fundraising and registration for  Wall Street Rides FAR (For Autism Research), a beautiful, supported bike ride through the lower Hudson Valley. Over 130 riders attended the happy hour at Rare View Rooftop Chelsea in New York City. This year's ride will be held on Saturday, October 7th and will highlight Westchester County's spectacular fall foliage.

All funds raised at the ride support ASF's  cutting-edge research programs examining the causes, diagnosis, and treatment of autism. There are multiple ride routes of varying distances, and the event is very family-friendly. Register today and join us!
Autism Sisters Project Profiled in  Newsweek

The Autism Sisters Project,
Jennifer (left) and Sarah (right) Ross with their mother and ASF Chief Science Officer Dr. Alycia Halladay Ross (middle).
supported by the Autism Science Foundation and the Hilibrand Foundation, was profiled in
Newsweek on June 10th. The Autism Sisters Project is an exciting opportunity for unaffected sisters of individuals with autism to participate in research alongside their sibling(s) with autism, to help researchers understand the so-called "female protective effect," a theory for why more males than females have autism, and why autism is expressed differently in males than in females. This article and accompanying video segment featured ASF Chief Science Officer Dr. Alycia Halladay Ross with her two daughters.

Click here to read the article, "Autism Risk: Why Are Girls More Protected From Diagnosis?" and watch the video.
ASF President Alison Singer made a cameo appearance.
Vaccine Segment Featured on
Last Week Tonight with John Oliver

The June 25th episode of Last Week Tonight with John Oliver included a hilarious and factually accurate segment about the importance of vaccines, highlighting the lack of a link between vaccines and autism. ASF President appeared on the segment, stating, "I think we were right to look at whether vaccines might be a cause of autism, but there comes a point where there is so much evidence--none of which shows any link between vaccines and autism--that you have to say 'enough.'"

Click here to watch this impressive segment.
How Is the Female Autism Brain Different?
By ASF Chief Science Officer, Alycia Halladay, PhD

Originally published on www.iancommunity.org

Males are four times more likely to be diagnosed with autism spectrum disorder (ASD) than females, but the reason why is unclear. A few years ago, a genetics study showed that females with ASD have a higher number of genetic mutations than males. 1 This finding led to the "female protective effect" hypothesis, which says that girls must have a higher number of genetic mutations in order to be diagnosed with autism. This hypothesis led investigators to compare the brains of males and females for evidence of the protective effect.

Most genetic studies look at DNA or RNA from saliva or blood. Because fewer females than males are diagnosed, fewer samples of female brain tissue are studied, and scientists understand less about females with autism. Through the resources of Autism BrainNet, Dr. Cyndi Schumann and colleagues were able to compare the brains of males and females. 2 Schumann's project found a higher number of potentially harmful genetic mutations in females in a newly discovered form of genetic material called microRNA. Surprisingly, the mutations were not found in genes known to be involved in autism. Rather, they were found in genes related to immune system function.

These findings are consistent with other studies of the brains of males and females with ASD. For example, Donna Werling and Daniel Geschwind discovered that gene expression changes between males and females were not in identified autism risk genes. 3 They were in genes that trim and shape neurons and control how they connect. The genes carry out these functions by regulating microglia--the major cell of the immune system in the brain.

Both studies highlight the importance of studying the human brain to understand autism. Also, the causes of the disparity in diagnosis in males and females might have more to do with the way that male and female brains work and less to do with autism risk genes. Finally, since there is a difference in the biology of autism in males and females, females may need different, specialized interventions and treatments. What is discovered in boys doesn't necessarily reflect what is going on in girls.

Autism BrainNet is an organization that coordinates the essential aspects of ASD brain tissue research. Without Autism BrainNet, understanding the brains of females with autism would not be possible. Please consider registering to receive more information about brain tissue research and donation at www.takesbrains.org.

References: 

1. Iossifov, I., O'Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., ... Wigler, M. (2014). The contribution of de novo coding mutations to autism spectrum disorder. Nature, 515(7526), 216-221. Abstract

2. Schumann, C. M., Sharp, F. R., Ander, B. P., & Stamova, B. (2017). Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain. Molecular Autism, 8, 4. Abstract

3. Werling, D. M., & Geschwind, D. H. (2013). Understanding sex bias in autism spectrum disorder. Proceedings of the National Academy of Sciences of the United States of America, 110(13), 4868-4869. Article

4. Jacquemont, S., Coe, B. P., Hersch, M., Duyzend, M. H., Krumm, N., Bergmann, S., ... Eichler, E. E. (2014). A Higher Mutational Burden in Females Supports a "Female Protective Model" in Neurodevelopmental Disorders. American Journal of Human Genetics, 94(3), 415-425. Article
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