June  2017
News
Trial Innovation Network Update
As introduced in the January/February 2017 and May 2017 CTSC Newsletters, the CTSA Trial Innovation Network is a new and rapidly developing national collaborative research network funded by the NIH National Center for Advancing Translational Sciences (NCATS). Proposed as a national trial “superhighway”, the goal of the Network is to execute clinical trials better, faster and more cost-efficiently. 

The Trial Innovation Network is designed to be a complementary resource for investigators and NIH Institutes.  Depending on the funding status of a proposal, the Trial Innovation Network will provide study investigators with a broad range of services and consultations (i.e. initial Network consultation or comprehensive consultation services) to help investigators develop proposals, optimize study operations and enhance recruitment and enrollment for a Network study that will ultimately utilize the resources of a CTSA Hub(s). 

**NEW** Updates to the Trial Innovation Network Website

On May 8th the Trial Innovation Network website was significantly updated to include:
  1. updated proposal information and online submission processes and
  2. a new Recruitment and Retention Toolkit
Stay tuned! More information will be forthcoming from the Trial Innovation Network as the framework grows and expands.

Noreen Roman, MT(ASCP), MBA, is the primary point of contact for the TIN and can be reached at  [email protected] or 216.778.3130 .
Congratulations to the March 2017 CTSC Core Utilization Pilot Awardees!
Jill Barnholtz-Sloan, PhD
Case Western Reserve University
School of Medicine
“Phosphoproteomic Elucidation of Anti-tumor Signaling Perturbations in Non-Small Cell Lung Cancer In Response to PP2A Activation and MEK Inhibition”
Abidemi Adegbola, MD
University Hospitals
Cleveland Medical Center
“Analysis of High Penetrance Candidate Gene Variant in Attention Deficit Disorder”
Michelle Treasure, MD
MetroHealth Medical Center
“A Pilot Study to Determine the Feasibility of a Low Glycemic Load Diet in Patients with Stage I-III Colon Cancer”
Vinay Varadan, PhD
Case Western Reserve University
School of Medicine
“Identifying Candidate Predictive Biomarkers of 15-PGDH Inhibitor Therapy for Intestinal Inflammation”
Kingman Strohl, MD
Louis Stokes Cleveland VA Medical Center “Transgenic Mice to Investigate Apoliproprotein A2 Expression in the Brain in Space and Time”
Congratulations to the March 2017 CTSC FDA Guidance Core Utilization Pilot Awardee!
Dean Nakamoto, MD
University Hospitals
Cleveland Medical Center
“Safety and Efficacy of Cryoablation in Management of Sialorrhea in Patients with Neurological Disorders”
CTSC KL2 Scholar Receives Multiple Awards
Congratulations to Mohamed Abazeed, MD, PhD on receiving the following awards!
  • American Society of Clinical Oncology (ASCO) 2017 Advanced Clinical Research Award in Breast Cancer
  • Cleveland Clinic Innovations (CCI) Young Innovator Award
Mohamed Abazeed, MD, PhD, of the Taussig Cancer Institute is truly at the cutting edge of medicine. His work focuses on the identification of genetic markers in cancer patients that will steer them to the right treatment.  Dr. Abazeed is also looking at modifying existing treatments to enhance their function and activity.  His work is attracting serious attention from some of the biggest pharma companies in the world, and he has been an enthusiastic partner with CCI.
Save the Date!
CTSC Education Reception
Tuesday, August 1, 2017
6-8 PM
Foundation House

RSVP: [email protected] or 216-444-2702

The Department of Epidemiology & Biostatistics at the School of Medicine is now the Department of Population and Quantitative Health Sciences
Dean Pamela B. Davis, MD, PhD has recently announced that the Depar tment of Epidemiology & Biostatistics at the School of Medicine has changed its name to the  Department of Population and Quantitative Health Sciences .

"The change superbly captures the dynamic scope of the department, giving substance and structure to the work of a multidisciplinary group of researchers dedicated to integrating population and quantitative methods to solve problems in human health. In addition to the previous emphasis on epidemiology & biostatistics, there has been major new interest within the department in such areas as, genetics, health outcomes research, community health, and public health, and most recently bioinformatics and computational biology," said Dr. Davis.

The Department of Population and Quantitative Health Sciences' new name describes its ever-evolving mission, newly extended breadth, and more cross-disciplinary collaboration efforts. Jonathan Haines, PhD (co-lead of the CTSC Informatics component) is the department chair. 

Healthy Adult Volunteers Needed

The Institute of Transformative Molecular Medicine (ITMM) at Case Western Reserve University is conducting a study on how storage affects the ability of banked blood to deliver oxygen.

We are seeking healthy adults with no known blood, lung, or circulatory disorder. Female participants will be tested to determine pregnancy status.

Participants will be asked to donate 1 unit of blood (about a pint) and then receive their blood back 21 days later (range 12-25 days) while being monitored for changes in heart rate, blood pressure and oxygen consumption.

There will be 4 study visits: 1) an initial health screen and physical exam; 2) blood donation; 3) a second health screen; and 4) blood transfusion. Visit 4 requires an overnight stay.

Study procedures involve blood sampling, placement of catheters in veins and arteries to monitor cardiovascular function and the placement of probes on the body to record oxygen delivery.

Financial compensation is provided.

For more information interested individuals should contact: [email protected].

CWRU IRB to Begin Accepting Biomedical Protocols in July

Beginning July 3, 2017, the Case Western Reserve University Institutional Review Board (CWRU IRB) will expand its scope to accept protocols that are biomedical in nature in addition to social, behavioral and educational research protocols.  Studies that take place at CWRU affiliate hospitals and/or involve patients, equipment or data at those sites will continue to be reviewed by the respective hospitals’ IRBs.  

It is anticipated that this change will primarily affect CWRU researchers whose studies are not performed in hospital settings but involve some biomedical procedures, such as:

  • prospective collection of blood, teeth, saliva and other biospecimens;
  • FDA-regulated drugs, devices and biologics (but only if administration in a hospital setting is not required);
  • collection of biomedical data through noninvasive procedures such as magnetic resonance imaging, electrocardiography, ultrasound, doppler blood flow, and echocardiography.

Starting in July, researchers wishing to submit biomedically-oriented studies to the CWRU IRB will use the current CWRU iRIS system to enter protocols on a revised form.  See below for training opportunities throughout the months of May and June.  Training sessions will provide step-by-step instructions to guide users through the new submission process.

Social and Behavioral researchers will not experience any changes when submitting protocol applications to the CWRU IRB.

Questions regarding the expansion of the CWRU IRB’s scope can be directed to Kim Volarcik at [email protected].

Training Sessions
All training sessions will be held in Sears Library Building, Room 670. 

Friday, June 9:               1 – 2 pm
Tuesday, June 13:         12 -1 pm
Wednesday, June 14:     11 am – 12 pm
Friday, June 16:              9 – 10 am
Friday, June 23:              1 - 2 pm
Thursday, June 29:         3:30 – 4:30 pm
Friday, June 30:              1 – 2 pm

Registration is online at:
https://research.case.edu/researchapps/education/onlinecalendar.cfm.

To schedule a targeted training session for an individual department or school, contact Tracy Wilson-Holden at [email protected].

News from the PRCHN
PRCHN Seminars
Healthy Neighborhoods
6/14/17-
Approach to multi-level modeling
Don Hedecker, PhD, University of Chicago

7/12/17 -
Ideas Moving Parents and Adolescents to Change Together (IMPACT) study findings
Elaine Borawski, PhD, and IMPACT Study Team

You can find more information on these seminars and other PRCHN programs   here.
For more news from PRCHN check out their  e-newsletter!

FreshLink Gearing up for Summer Market Season
The  FreshLink staff has unveiled a resource library and demonstration kits for use by nine FreshLink Ambassadors, who will be working in the Cudell, Glenville, and University Circle neighborhoods this summer.
News from the Urban Health Intiative
The overriding theme is how the lack of digital skills, telephone and computer equipment, and connectivity affect social health inequalities and vice versa
In attending the second annual  National Digital Inclusion Alliance Summit in St. Paul, Urban Health Initiative Executive Director, Amy Sheon, PhD, MPH, had the opportunity to find some great new resources that:

At the summit, Dr. Sheon spoke about the potential return on investment from training Community Health Workers (PPT) to conduct digital skill assessment, referral to community partners for digital skill training and low cost connectivity, and then train patients to use portals to the personal health record.

Dr. Sheon has also been participating in an effort led by City Councilman Brian Cummins to create an umbrella structure to build the open data ecosystem in Cleveland.  Other participants include our colleagues from the Center on Urban Poverty at the Mandel School, DigitalC, Global Shapers, Cleveland Neighborhood Progress, Open NEO, Hack Cleveland, and more.  These partners often turn to Health Data Matters for guidance on how to integrate and share data, so thanks as always to Dr. Scott Frank, Health Data Matters co-director, and our wonderful Health Data Matters partners at the Center on Urban Poverty, the Cuyahoga County Board of Health, the Cleveland Department of Public Health, LiveStories, and more. 

On May 10th, Councilman Cummins convened a joint meeting of the Health & Human Services, Workforce & Community Benefits, Development, Planning & Sustainability, and Utilities Committees for a morning-long hearing on the Digital Divide in Cleveland.  Dr. Sheon testified on the community health worker project, alongside Adam Perzynski, PhD, shown here speaking to Council and a standing-room only crowd.

Finally, Dr. Sheon has had the pleasure of getting to know some folks at IBM Watson, the group that acquired our hometown Cleveland Clinic spinoff, Explorys.  On May 30th, a number of folks gathered at MetroHealth to view an Executive Webinar, "Redefining Population Health" about how population health is moving from the healthcare system to the entire community.  The webinar covered the work of the IBM Health Corps initiative to build a community health strategy for Durham County with Duke Health.  The platform they are building could offer much to local efforts here around how data can be used to understand and affect the relationship between social determinants of health and health outcomes.  At the same time, the dynamics encountered by the Health Corps in Durham are very reminiscent of ones here, so some of the local solutions that have been developed could benefit the efforts of the IBM team.  Contact Amy Sheon if you want to know more! 

Amy R. Sheon, Ph.D., M.P.H.
Executive Director, Urban Health Initiative
[email protected]

News from our Colleagues
Funded by NCATS, SMART IRB is designed to streamline the IRB ethical review process for multisite studies involving as few as two sites to over one hundred. With SMART IRB, institutions can agree to allow one institution to become the reviewing IRB for a study, while the other institutions “rely” on that IRB’s oversight, from initial review to study closeout. SMART IRB is poised to support a wide range of collaborative research across the nation, and is freely available to all users.

SMART IRB, which stands for the “Streamlined, Multisite, Accelerated Resources for Trials,” is the result of many years of collaboration among CTSA Program hubs and the adoption of concepts that had appeared in several regional reliance models.
NIH Extramural Nexus
Save the Date for NCATS Advocacy Day
June 30, 2017
NCATS will host its inaugural  NCATS Advocacy Day - Partnering with Patients for Smarter Science on  June 30, 2017, 9:00 a.m. - 4:00 p.m., at the John Edward Porter Neuroscience Research Center, National Institutes of Health, Bethesda, Maryland. The goal is to inform patients and their advocates about NCATS and its programs, identify patient needs and collectively discuss ways for enhanced patient inclusion in NCATS'  translational science activities.

Research Highlights
KL2 Scholar, Nathan Makowski, PhD, Studies Long-term Assistive System for MS, Stroke Patients
Using technology designed by Case Western Reserve University and the Advanced Platform Technology and Functional Electrical Stimulation (FES) centers at the Louis Stokes Cleveland Veterans Affairs Medical Center, stroke and MS patients are able to walk significantly better. FES technology has been used primarily for therapy in stroke patients in the past. "This, though, is a more long-term assistive system," said Dr. Makowski.

Read more
Jackson Wright Receives Hovorka Prize
Dr. Wright, former co-director of the CTSC Clinical Research Unit Services Core, is a global authority on evaluating and managing hypertension, particularly in African-Americans. He has had senior roles in nearly all major clinical trials conducted in that population over the past three decades. His contributions include new treatment approaches for high blood pressure and raising awareness of the need for more minority subjects in clinical research. As a result of these achievements (and many others), Wright will receive the 2017 Frank and Dorothy Humel Hovorka Prize, one of the University’s highest forms of recognition.
Noteworthy Research
Events
OHRP Research Community Forum
September 6-7, 2017
Northern Kentucky Convention Center, Covington, KY
The Cincinnati CTSA will be hosting a two-day human subject protection forum consisting of an academic conference and an applied workshop relevant for institutional review board (IRB) members, IRB administrators, clinical investigators, research scientists and support staff, sponsors, contract research organizations, government regulators, and members of the research community.
Representatives from the Office of Human Research Protection (OHRP) and other federal agencies as well as research experts will provide perspectives and resources for interpreting and applying human subject protections in an evolving regulatory landscape.
Tracks include:
  •          Social/behavioral research
  •          Biomedical research
  •          Innovative research
  •          Regulatory landscape
  •          Community engagement

Meeting of the Minds 2017 Annual Summit
October 23-25, 2017
Global Health Innovation Center - Cleveland, OH
The Meeting of the Minds Summit is a forward-looking conference for sharing strategies with scalable solutions in urban neighborhoods.The summit will include speakers and sessions that aim to share innovative sustainability and technology solutions between people from around the globe.

Funding Opportunities
Atomwise, Inc.
Application Deadline: June 12, 2017
Atomwise Inc seeks proposals from innovative university scientists to receive 72 potential medicines, generated specifically for their research by artificial intelligence. The Artificial Intelligence Molecular Screen (AIMS) program is designed to dramatically accelerate the race towards life-saving drugs by analyzing millions of compounds for each disease. Contributing cutting-edge AI technology and delivering physical molecules to as many as 100 labs, the program is the first of its kind.

AIMS is a streamlined program. Short applications are submitted online, and recipients will be announced three months from the submission deadline. No preliminary data is required and projects showing success can receive further support.

Atomwise develops artificial intelligence systems for drug discovery. Its groundbreaking AtomNet technology reasons like a human medicinal chemist, using powerful Deep Learning algorithms and supercomputers to analyze millions of potential treatments each day. 

Historically, discovering a single new medicine cost billions of dollars and took an average of 15 years – putting such research outside the reach of academic scientists. Atomwise helps predict the effectiveness of new drugs more rapidly, much like software used to simulate aircraft, buildings, and computer chips. 

Atomwise has already launched 27 drug discovery projects with leading research institutions. These partnerships are advancing research on diseases as diverse as Ebola, multiple sclerosis, and leukemia. Molecules predicted by Atomwise have become lead medicinal chemistry candidates and successfully treated animals in trials. 

Application Deadline: June 12, 2017

For more information visit the  Atomwise website.
Howard Hughes Medical Institute (HHMI) - 2018 HHMI Investigator Competition
Application Deadline: June 27, 2017

The Howard Hughes Medical Institute (HHMI) has announced that it seeks to appoint up to 20 new biomedical researchers through a national open competition. HHMI recently increased the standard term for HHMI investigators from five to seven years, providing longer term, flexible support as these scientists explore new research territory. The initiative represents an investment of approximately $168 million in basic biomedical research over the next seven years.

The HHMI investigator competition is open to basic researchers and physician scientists at more than 200 eligible institutions who bring innovative approaches to the study of biological problems in biomedical disciplines, plant biology, evolutionary biology, biophysics, chemical biology, biomedical engineering, and computational biology. Those selected in this competition will receive a seven-year appointment to HHMI, which is renewable pending favorable scientific review.

HHMI encourages its investigators to push their research fields into new areas of inquiry. By employing scientists as HHMI investigators—rather than awarding them research grants—the Institute is guided by the principle of “people, not projects.” HHMI investigators have the freedom to explore and, if necessary, to change direction in their research. Moreover, they have support to follow their ideas through to fruition—even if that process takes many years.

Application Deadline: June 27, 2017

For more information visit the HHMI website.

American Heart Association - Methods Validation Grants
Application Deadline: June 29, 2017

The Methods Validation Grants will focus on validating pre-existing methods including algorithms and analytic tools used to maximize the use of data in predicting outcomes. 

The purpose of the Methods Validation Grants is to identify methods to improve the integration and analysis of data within and across large and diverse datasets using cloud computing. A successful grant will include information on how the previous method or tool was used, the evaluation and validation of the proposed method, and the plan for utilizing the AHA Precision Medicine Platform http://precision.heart.org to serve the greater scientific community. 

The award seeks to test and validate:

  • new machine learning algorithms to curate and harmonize data in the cloud;
  • new natural language processing methods for electronic health records in the cloud;
  • new pipelines to enable more effective and efficient workflows for analyzing data in the cloud;
  • New pipelines for data curation in the cloud


These grants are open to all scientists. Knowledge of biology and/or computer science may be helpful. Collaboration with other scientists (in any field) is optional. Applicants are to provide proposals that adhere to the above broad objectives while specifically addressing the outlined goals. Faculty/ staff members conducting independent research at time of application. At application, principal investigator must hold an M.D., Ph.D., D.O. or equivalent terminal doctoral degree and must meet institutional requirements for grant submission. There are no field of study restrictions so long as the applicant demonstrates ability to complete the project proposal with the allotted time and money made available by the grant. Awardee must meet American Heart Association citizenship criteria and research status if at a foreign university throughout the duration of the award. Applicants are not required to reside in the U.S. for any period of time before applying for American Heart Association funding. 

Application Deadline: June 29, 2017

For more information visit the AHA website.

Humane Society International – Roadmaps to Human Biology-based Disease Research
Application Deadline: June 30, 2017

To support strategic scientific dialogue around the concept of extending the vision of “21st century toxicology” to the wider biosciences, Humane Society International and The Humane Society of the United States are offering grants of up to $10,000 (USD) in funding to support the development and open-access publication of in-depth, independent review articles in discrete areas of human disease/biomedicine by health scientists with relevant expertise.

Each review should:

  • Examine the state of the science in a specific area of human biomedicine, including current understanding of the underlying pathophysiological pathways and networks;
  • Critically evaluate the human relevance, translational success and limitations of conventional research models;
  • Offer concrete recommendations/roadmap for optimizing the funding and use of advanced, human-specific tools and approaches (pathway paradigm as an organizing framework, primary human cells/tissues, iPSC, organoids, bioengineering, computational systems biology modeling, etc.) in the disease area under discussion; and
  • Be accepted for publication in a high-visibility, peer-reviewed journal.

A scientific workshop will be convened in early 2019 to explore the findings and recommendations of funded review articles. Lead authors will be invited to attend and present their work, and contribute to a subsequent workshop report. Travel, accommodations and meals will be arranged.

For more information visit the HSI website.

Little Giraffe Foundation
Application Deadline: July 14, 2017
The  Little Giraffe Foundation  is dedicated to funding neonatal research and supporting patients and parents of the NICU. The foundation is accepting Letters of Intent for 2017.

Grants of up to $10,000 will be awarded to qualified scientists, doctors, and nurses at universities, hospitals, and research institutions in support of research that addresses both the long-term and immediate health needs caused by premature birth as well as the causes of premature birth and ways to prevent it. Research subjects appropriate for support include basic biological processes governing development, genetics, clinical studies, studies of reproductive health, environmental toxicology, and social and behavioral studies. 

Letter of Intent Deadline: July 14, 2017

For more information visit the Little Giraffe website.

NIH: Neoantigen-Based Therapeutic Targeting of Head and Neck Cancers (R01)
Application Deadline: July 19, 2017
The purpose of this Funding Opportunity Announcement (FOA) is to support basic and preclinical research aimed at developing novel immunotherapeutic targets for head and neck cancers (HNC), including salivary gland cancers. Research supported by this FOA will identify human HNC-specific neoantigens, and will test the utility of these neoantigens as targets for eliciting anti-tumor immune responses in affected patient populations. 

Application deadline is July 19, 2017. 

For more information visit the  NIH website.
Special Funding Opportunities & Notices
Multiple Deadlines
NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3)
NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01)
(PAR-17-184)
 
Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R21)
(PAR-17-187) 

Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R03)
(PAR-17-188) 

Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R01)
(PAR-17-189) 

Advancing the Science of Geriatric Palliative Care (R21)
(PA-17-226) 

Avenir Award Program for Research on Substance Abuse and HIV/AIDS (DP2)
(RFA-DA-18-004)

Mechanisms and Consequences of Sleep Disparities in the U.S. (R01)
(PAR-17-234) 

Innovative Research in Cancer Nanotechnology (IRCN) (R01)
(PAR-17-240)

Notice of Information Regarding the "Announcement of Antimicrobial Resistance Rapid, Point-of-Need Diagnostic Test Challenge Competition" 
(NOT-OD-17-063)

NIH and FDA Release Protocol Template for Phase 2 and 3 IND/IDE Clinical Trials
(NOT-OD-17-064) 

Catalyzing Innovation in Late Phase Clinical Trial Design and Statistical Analysis Plans (U34) 
(RFA-HL-18-008)

Catalyzing Innovation in Late Phase Clinical Trial Design and Statistical Analysis Plans (X01)
(RFA-HL-18-009)

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R21)
(PAR-17-293)

Catalyzing Innovation in Late Phase Clinical Trial Design and Statistical Analysis Plans Resource Access (X01) 
(PAR-17-294) 

NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U01)
(PAR-17-274)

NIH StrokeNet Small Business Innovation Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U44) 
(PAR-17-275)

NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention Infrastructure Resource Access (X01)
(PAR-17-277)

Notice of Intent to Publish a Funding Opportunity Announcement for Consortium on Translational Research in Early Detection of Liver Cancer (Clinical and Research Centers (U01)
(NOT-CA-17-060)

Notice of Intent to Publish a Funding Opportunity Announcement for the Coordinating Center for the Consortium of Translational Research in Early Detection of Liver Cancer (U24)
(NOT-CA-17-061)

NIH-Industry Program Opportunities
Multiple Deadlines

Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UG3/UH3) 

(RFA-TR-17-002)
 

  • National Center for Advancing Translational Sciences
  • National Institute of Dental and Craniofacial Research
  • Application Receipt Date(s): September 15, 2017, by 5:00 pm local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. 
Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UG3/UH3) 

(RFA-TR-17-003)
 

  • National Center for Advancing Translational Sciences
  • National Institute of Dental and Craniofacial Research
  • Application Receipt Date(s): September 15, 2017, by 5:00 pm local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. No Late applications will be accepted for this FOA. 
Department of Defense
Multiple Deadlines
Lung Cancer Research Program  
Concept Award
Career Development Award
Idea Development Award
Investigator-Initiated Translational Research Award
Translational Research Partnership Award

Multiple Sclerosis Research Program
Exploration - Hypothesis Development Award
Investigator-Initiated Research Award

Vision Research Program
Clinical Trial Award
Technology/Therapeutic Development Award

Amyotrophic Lateral Sclerosis Research Program
Therapeutic Idea Award
Therapeutic Development Award

Breast Cancer Research Program
Breakthrough Award Levels 1 and 2
Breakthrough Award Levels 3 and 4
Breakthrough Fellowship Award
Distinguished Investigator Award
Era of Hope Scholar Award
Innovator Award

Bone Marrow Failure Research Program
Idea Development Award

Multiple Sclerosis Research Program
Investigator-Initiated Research Award

Ovarian Cancer Research Program
Clinical Development Award
Investigator-Initiated Research Award
Ovarian Cancer Academy Award – Early Career
Investigator
Pilot Award

Detailed descriptions of the funding opportunity, evaluation criteria, and submission requirements can be found in the Program Announcements. The Program Announcements are available electronically for downloading from the Grants.gov website , the CDMRP website and the electronic Biomedical Research Application Portal (eBRAP) .