Spotlight on:
New CPCE Pilot Grant
Last month, CPCE awarded a pilot grant to
Allison Barz Leahy, MD
. Dr. Barz Leahy is a Fellow in the Division of Oncology, and she is currently funded by the
Pediatric Hospital Epidemiology and Outcomes Research Training (PHEOT) program
, managed by CPCE. Her mentors on the pilot grant project are CPCE Core Faculty member
Richard Aplenc, MD, PhD, MSCE
and Ethan Basch, MD, MSc, an adult oncologist from the University of North Carolina Comprehensive Cancer Center.
The pilot project proposed by Dr. Barz Leahy will examine the feasibility of integrating patient reported outcomes (PROs) for symptom and toxicity monitoring for children hospitalized for chemotherapy. PROs are reports of a patient’s health condition directly from the patient, without modification by the physician. The use of PROs for symptom monitoring in adult cancer patients has been shown to increase quality of life and has a survival benefit. The hope is that pediatric cancer patients will see similar benefits.
The study will enroll 50 patients (age 8+) who, along with their caregivers, will track their symptoms daily, using a validated, standardized, web-based tool. Results will lay the groundwork for a large-scale randomized controlled trial to test the impact of PROs for symptom monitoring on outcomes for pediatric cancer patients.
CPCE offers
Pilot Grants
twice per year to support CHOP investigators in clinical effectiveness studies that will attract external support for larger-scale projects. The next deadline is April 2. Please
contact us
with questions.
|
|
|
|
Inaugural Innovation Series Lecture
Date: January 23, 2018
Time: 1:00 - 2:00 pm
Location: Colket Translational Research Building, 1200A
The Offices of Entrepreneurship and Innovation, and Tech Transfer, Commercialization, and Innovation have created a new education opportunity for those interested in developing innovation, being more entrepreneurial, and supporting the next breakthroughs – The Innovation Series. Featuring Anthony Green and Sri Sriadibhatla from Ben Franklin Technology Partners (BFTP), this lecture will provide attendees the opportunity to learn how BFTP supports local innovation and startup companies with seed funding from a variety of sources. Register
here.
1st CHOP Education Symposium
Date: January 24, 2018
The event will feature Grand Round Speaker Barbara Brandt, PhD, Director of the National Center for Interprofessional Practice and Education. The CHOP Interprofessional Education (IPE) Committee invites staff from all departments to share their work and engage in shaping the future of learning.
Writing/Designing Winning NIH Proposals Workshop
January 30, 2018
Time: 8:30 am - 4:30 pm
Location: The Arch, 3601 Locust Walk, Room 108
Sponsored by The Grant Training Center, this one-day comprehensive workshop is geared towards those who wish to submit winning proposals to the National Institutes of Health (NIH), in time for the next NIH grant submission deadline. A workshop fee of $395.00 includes a comprehensive directory, workbook, certificate of completion, and continental breakfast.
Learn more.
Save the Date: 10th Annual CHOP Research Safety Day
Date: April 19, 2018
Time: 10:00 am - 2:00 pm
Location: Colket Translational Research Building lobby and conference rooms
Formal invitations and more details will follow soon. Please feel free to contact Research Safety with any questions at (267) 426-2272 or at
researchsafety@email.chop.edu.
Penn MSHP 2018 Implementation Science Institute
Dates: June 19 - 21, 2018
Location: Jordan Medical Education Center
The purpose of the Implementation Science Institute is to provide participants with the tools to design and execute rigorous implementation science research. The Institute will give an introduction to the foundations of implementation science, cover implementation strategies and sustainability, tips for grant writing and skill development. Limited scholarships will be available for affiliates of CHOP. Register
here or contact
mshp@mail.med.upenn.edu for more information.
|
|
December 22, 2017
December 19, 2017
December 13, 2017
December 11, 2017
December 5, 2017
November 21, 2017
November 18, 2017
November 18, 2017
November 17, 2017
|
|
To make initial care management decisions, clinicians must estimate the probability of Lyme disease before diagnostic test results are available. The objective of this research for Pedi Lyme net was to examine the accuracy of clinician suspicion for Lyme disease in children undergoing evaluation for Lyme disease.
The ethics of maternal-fetal surgery involves weighing the importance of potential benefits, risks, and other consequences involving the pregnant woman, fetus, and other family members. Dr. Feudtner and colleagues assessed clinicians' ratings of the importance of 9 considerations relevant to maternal-fetal surgery.
Coadministration of IV vancomycin and piperacillin/tazobactam may increase the risk of AKI in hospitalized children. Pediatricians must be cognizant of the potential added risk of this combination therapy when making empirical antibiotic choices.
Children with acute myeloid leukemia (AML) whose disease is refractory to standard induction chemotherapy therapy or who experience relapse after initial response have dismal outcomes. This research sought to comprehensively profile pediatric AML microRNA (miRNA) samples to identify dysregulated genes and assess the utility of miRNAs for improved outcome prediction.
The US Food and Drug Administration's December 2016 approval of nusinersen for the treatment of patients with all subtypes of spinal muscular atrophy ushered in a new era for patients with spinal muscular atrophy, their families, and all those involved in their care. The extreme cost of the medication and the complicated logistical requirements for administering nusinersen via lumbar puncture have created practical challenges that raise important ethical considerations.
Cutaneous lesions are often the first marker of invasive mold infection, which can cause substantial morbidity in immunocompromised children. The purpose of this study was to describe the evaluation and outcomes of immunocompromised children who presented with findings requiring skin biopsy because of concern about invasive infection.
The prevalence of pediatric antimicrobial stewardship programs (ASPs) is increasing in acute care facilities across the United States. Over the past several years, the evidence base used to inform effective stewardship practices has expanded, and regulatory interest in stewardship programs has increased. Dr. Gerber and colleagues review approaches for established, hospital-based pediatric ASPs to adapt and report standardized metrics, broaden their reach to specialized populations, expand to undertake novel stewardship initiatives, and implement rapid diagnostics to continue their evolution in improving antimicrobial use and patient outcomes.
Acute respiratory tract infections account for the majority of antibiotic exposure in children, and broad-spectrum antibiotic prescribing for acute respiratory tract infections is increasing. It is not clear whether broad-spectrum treatment is associated with improved outcomes compared with narrow-spectrum treatment. This research compares the effectiveness of broad-spectrum and narrow-spectrum antibiotic treatment for acute respiratory tract infections in children.
Marked variation in positive end-expiratory pressure (PEEP) levels for extremely low birth weight infants exists between neonatal centers. Research providing evidence-based guidance for this important aspect of respiratory care in preterm infants at high risk of lung injury is needed.
Youth with rheumatologic diseases have a high prevalence of comorbid mental health disorders and are at increased risk for adverse outcomes. Early identification and treatment of mental health disorders has been shown to improve outcomes, but current systems of care fall short in providing adequate mental health services to those in need. Pediatric rheumatologists are uniquely positioned to provide mental health screening and intervention for youth with rheumatologic diseases due to the frequency of patient encounters and ongoing therapeutic relationship with patients and families.
Temperature and relative humidity have opposing effects on evaporative water loss, the likely mediator of the temperature-dependence of nephrolithiasis. However, prior studies considered only dry-bulb temperatures when estimating the temperature-dependence of nephrolithiasis. Dr. Tasian and colleagues used distributed lag non-linear models and repeated 10-fold cross-validation to determine the daily temperature metric and corresponding adjustment for relative humidity that most accurately predicted kidney stone presentations during hot and cold periods in South Carolina from 1997 to 2015.
Total body irradiation (TBI) is commonly used in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) to treat benign and malignant disease. Though life-saving, these therapies place patients at risk for important side effects, including musculoskeletal complications such as short stature, osteonecrosis, slipped capital femoral epiphysis, and the development of benign and malignant bone tumors. With an increasing number of HSCT survivors, there is a growing need for awareness of the musculoskeletal complications of HSCT and TBI.
|
|
This award provides $25,000 for one year to a recipient at any career stage performing research in gastroenterology- or hepatology-related areas. The objective of this pilot research award is to provide funds to early career investigators to help establish their research careers, or to support projects that represent new research directions for established investigators.
The American Gastroenterological Association is accepting applications for its AGA-Elsevier Gut Microbiome Pilot Research Award. The objectives of the program are to help early-career investigators establish their research careers and support research projects that represent new directions for established investigators. Projects must focus on the relationship of gut microbiota to digestive health and disease.
The Caplan Foundation for Early Childhood is intended to be an incubator of promising research and development projects that may ultimately enhance the development, health, safety, education or quality of life of children from infancy through seven years of age across the country. Each of its grants is made with the expectation that a successful project outcome will be of significant interest to other investigators or developers, within the grantee’s field of endeavor, and will be amenable to beneficial application or adaptation elsewhere. In essence, the foundation’s goal is to provide seed money for those imaginative endeavors, addressed to the needs of young children, which appear most likely to bear fruit on a national scale.
Planning and Implementation Grants: Grants of up to $10,000 will be awarded to individual pediatricians and fellowship trainees for the planning of innovative community-based child health initiatives that ensure all children in the community have access to healthcare services not otherwise available. Priority will be given to projects that serve communities with the greatest health disparities. Outreach must be to the community at large, not to practice or clinic patients only, and all initiatives should incorporate screening for or connecting children to medical homes and available insurance programs. Resident Grants: Grants of up to $2,000 will be awarded to pediatric residents for the planning and/or implementation of community-based child health initiatives. Projects must include planning activities or demonstrate completed planning activities, and may include implementation activities.
NKF will award grants of up to $35,000 in support of research projects in the field of nephrology and related disciplines conducted by individuals who have completed fellowship training and who hold a junior faculty position at a university-affiliated medical center in the United States. Projects must be patient-oriented. Elements of patient-oriented research activities may include but are not limited to development of new technologies, mechanisms of human disease, educational or therapeutic interventions, epidemiological studies, health policy studies, and clinical trials.
The
Thrasher Research Fund provides grants for clinical, hypothesis-driven research that offers substantial promise for meaningful advances in the prevention, diagnosis, and treatment of children's diseases, particularly research that offers broad-based applications. The fund is inviting concept papers for its Early Career Awards Grants program. Through the program, the fund awards small grants of up to $25,000 to new researchers to help them gain a foothold in the area of pediatric research. The program will consider a variety of research topics important to children's health but will give priority to applicants who show great potential to impact children's health through medical research.
The Damon Runyon Cancer Research Foundation has joined together with the Sohn Conference Foundation, dedicated to curing pediatric cancers, to establish the Damon Runyon-Sohn Pediatric Cancer Fellowship Award. This award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers.
The foundation awards grants for research focused on issues faced by care providers that, when implemented, will improve health, nutrition, and/or developmental outcomes for infants and young children. Projects can address the etiologic mechanisms of disease; new, improved, or less invasive diagnostic procedures; the reduction or elimination of side effects; the alleviation of symptoms; new, improved, or less invasive therapies or treatments; dosage or dosing requirements or mechanisms for drugs, nutrient supplementation, or other therapeutic measures (under or overdosing); and preventative measures. The total requested grant size should be no more than $350,000.
Last year, the NIH received approximately $30 billion in federal support. In spite of this amount, about 42,500 grants were not funded. To address these unfunded proposals, the NIH has a new Pilot Program that is designed to match researchers with nonprofit disease Foundations or with investments from private companies. Through a new collaboration between the NIH and the private contractor Leidos, researchers can now upload their unfunded NIH Proposals into an online portal at the Online Partnership to Accelerate Research (OnPAR). Foundations and other potential funders can review the NIH scores, and decide whether they might be interested in funding the Projects. Currently, this Pilot Program allows researchers with priority scores better than the 30th percentile to submit their abstracts. Interested Foundations might ask that a researcher send their full NIH Application along with its scores. The consensus opinion is that there are a lot of worthy grants being submitted to the NIH, but there is only so much funding available. OnPAR is one way of trying to match researchers with private Foundations.
|
|
About CPCE
We are a pediatric research center dedicated to discovering and sharing knowledge about best practices in pediatric care by facilitating, organizing and centralizing the performance of clinical effectiveness research -- research aimed at understanding the best ways to prevent, diagnose and treat diseases in children. CPCE’s multidisciplinary team conducts research on a diverse range of clinical effectiveness topics grouped within four areas of research:
|
|
|
|
|
|
|
