UC Davis School of Veterinary Medicine
VETERINARY CENTER FOR CLINICAL TRIALS
Clinical Trials Report
April 2017
NEW CLINICAL TRIALS
Assessing a New Diagnostic Tool for Elbow Dysplasia in Dogs

It is essential that clinicians accurately identify and diagnose the different lesions in the joint to make appropriate decisions about how best to treat elbow dysplasia and predict surgical outcome.  Therefore, the purpose of this study is to evaluate the use of a micro-invasive arthroscope system for the diagnosis of elbow dysplasia in dogs.

Investigating a New Treatment for Lymphoma in Dogs

Fermented wheat germ proteins (FWGP) has been shown to be a potent immune modulator that could activate immune cells called Natural Killer (NK) cells. The purpose of this trial is to determine if FWGP promotes anti-cancer immunity and to evaluate the safety and efficacy of the FWGP product when administered orally in dogs with lymphoma.  

FEATURED ONGOING CLINICAL TRIALS
Understanding How the Body Processes a Chemotherapy Drug in Cats with Lymphoma

Despite the wide use of chlorambucil in cats with small cell GI lymphoma, the pharmacokinetic parameters have not been previously studied in cats. Knowledge of the pharmacokinetic parameters of chlorambucil in this population of older, cancer-bearing cats is critical to understand why some cats experience side effects with chlorambucil therapy and determine if variability in the metabolism of chlorambucil contributes to treatment failure.

Assessing Two Medications for Treatment of Pulmonic Stenosis in Dogs

Pulmonic stenosis (PS), the one of the most common congenital heart defects encountered in dogs, is characterized by a narrowing of the outlet of the right side of the heart. We are studying the effects of two commonly utilized medications - butorphanol, a mild sedative commonly used to help facilitate heart ultrasounds and atenolol, a beta-blocker commonly utilized to help treat PS - on heart function and assessment of disease severity in dogs with PS.  

Finding a New Treatment for Pemphigus Foliaceus in Dogs

Although it is a rare skin disease, pemphigus foliaceus (PF) is the most common form of pemphigus and probably the most common cutaneous autoimmune disease in the dog. The goal of this study is to assess the efficacy of a Bruton's Tyrosine Kinase inhibitor (BTKi) as a therapy for canine pemphigus foliaceus.
Using a New Device to Treat Urinary Incontinence in Dogs

Various surgical treatment options have been described for dogs that do not respond to medical management or experience adverse effects from medications; however, these procedures are invasive and are not always successful. Therefore, the purpose of this study is to test a new device, which uses heat to alter the structure of collagen in the wall of the urethra and thereby strengthen the wall and decrease leakage), to treat urinary incontinence in female dogs.

Investigating New Treatments for Bladder Stones (2 trials)

Trial #1 aims to  evaluate the efficacy of a therapeutic diet for struvite dissolution in dogs.

Trial #2 focuses on evaluating  the effects of an oral nutraceutical on cystine solubility in the urine.

Printable Flyer (#1, #2) |  Read more...
Understanding the Genetics Behind Chronic Progressive Lymphedema in Friesian Horses

Chronic Progressive Lymphedema (CPL) is a debilitating disorder affecting the lymphatic system in the lower limbs of many draft horses. The higher rate of incidence within certain draft horse breeds (Shires, Clydesdales, Belgians) seem to indicate there is a possible genetic component to CPL. The purpose of this study is to identify the genetic component underlying CPL in Friesian horses.  

Evaluating a New Drug Delivery System for Dogs with Brain Tumors

This clinical trial is being done to investigate whether small particles call nanoporphyrins can be used to better visualize tumors during surgery and potentially to see if they will be a useful method to deliver drugs into brain tumors for treatment. 

Understanding the Genetics Behind Sudden Acquired Retinal Degeneration Syndrome in Dogs

Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of permanent blindness in dogs; however, the underlying cause for SARDS is unknown and no treatment exists. The purpose of the study is to better characterize this disease with hopes of identifying protein biomarkers and/or the genetic components of this disease.  

Identifying Lymph Node Metastasis in Dogs with Lung Cancer

Knowing whether or not there is metastatic tumor in the regional lymph nodes is very important prognostic information for dogs with lung tumors, as dogs that do not have metastatic disease in their lymph nodes in general have a much longer lifespan. The aim of this study is to provide information that will allow us to better identify these lymph nodes at surgery, improve safety of surgical dissection, and minimize surgical time during removal of these lymph nodes.
  
  Read more...  
Using a New Technique to Shrink Liver Tumors in Dogs

When liver tumors in dogs cannot be removed with surgery, treatment options are limited or non-existent. In humans, one of the standard treatments for those cases is transarterial embolization (TAE), which eliminates the blood supply of the tumor and may decrease tumor size. Therefore, the objectives of this study are to 1) describe the procedure of TAE in a group of dogs with naturally-occurring liver cancer, and 2) evaluate the effect of TAE on clinical signs and the size of the tumor.    
 
TRIAL UPDATES
Clinical Trials that are "On Hold" 
  • Evaluating a Novel Formulation of Chemotherapy for Dogs with Lymphoma
  • Assessing a Potential Treatment for Mast Cell Tumors in Dogs
  • Evaluating a Stem Cell Therapy for Inflammatory Bowel Disease
  • Laser Ablation for Treatment of Ectopic Ureters in Dogs
  • Stem Cell Therapy for Dogs with Acute Severe Spinal Cord Injury
NOTE: Trials that are "On Hold" are not accepting new patients and we do not know when these trials will open back up.  If/when these trials do accept new patients again, we will notify you via this report and post information about the study (including contact information) on the VCCT website.

 
Clinical Trials that are Recently Completed or Finished Enrollment
  • Plasmid IL-12 + Electroporation Treatment for Soft Tissue Sarcoma in Dogs
  • Sentinel Lymph Node Mapping in Dogs with Mast Cell Tumors
  • Treating Foals with Neonatal Maladjustment Syndrome with the Madigan Assisted Squeeze Technique
  • Biomarkers of B-cell Lymphoma in Dogs
  • A Radiologic Percutaneous Gastropexy Technique in Dogs
  • Evaluating CT Pneumocolography as a Diagnostic Tool for Large Bowel Disease in Dogs
  • Looking at the Role of Genetics in Canine Pulmonary Hypertension and Response to Sildenafil
THANK YOU!
Thank you for wanting to be a part of our clinical trials program.  We greatly appreciate your desire to participate in and inform others about our trials, and/or refer cases to the Veterinary Medical Teaching Hospital (VMTH).  The VCCT and our clinical trials wouldn't be here without you!  
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