January 2017 Features
Announcements
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Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research Application Due Dates: February 15, 2017; August 15, 2017; February 15, 2018; August 15, 2018 Expiration Date: August 16, 2018 Note: Preliminary applications are due by February 15, 2017, and full applications are due by April 3, 2017.
Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations Application Due Date: March 1, 2017 Expiration Date: March 2, 2017
Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program Application Due Date: March 7, 2017 Expiration Date: March 8, 2017
Emerging Questions in Cancer Systems Biology Application Due Date: June 23, 2017; November 24, 2017; June 22, 2018; November 23, 2018 Expiration Date: November 24, 2018
Administrative Supplements to Promote Research Collaborations on Fusion Oncoproteins as Drivers of Childhood Cancer Application Due Dates: March 28, 2017; November 8, 2017; March 28, 2018 Expiration Date: March 29, 2018
International Research in Infectious Diseases, including AIDS Application Due Dates: May 22, 2017; May 22, 2018; May 22, 2019 Expiration Date: August 23, 2019
Fertility Status as a Marker for Overall Health Application Due Dates: Standard dates apply. Expiration Date: May 8, 2020
PA-17-109 (R21)
Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults Application Due Date: Standard dates apply. Expiration Date: January 8, 2020
NIH Center for Inherited Disease Research (CIDR) Program Application Due Date: March 9, 2017; May 11, 2017; July 13, 2017; September 7, 2017 Note: Additional instructions for NCI grantees are available at https://epi.grants.cancer.gov/genomic-resources/cidr.html.
* NCI is not participating in these funding opportunities.
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NOT-OD-17-030 NIH & AHRQ Update Font Guidelines for Applications to Due Dates On or After January 25, 2017
NOT-OD-17-037 NIH Implementation of the Interim-RPPR while a Renewal Application is Under Consideration
NOT-OD-17-038 Notice of the Publication of the Final Rule on the Federal Policy for the Protections of Human Subjects (Common Rule) |
Querying and Downloading Data using the GDC Data Portal and the GDC Data Transfer Tool February 2, 2017
Identifying Opportunities for Symptom Management Research in Response to Blue Ribbon Report February 3, 2017
SeqSPACE Webinar Series: ICGC/TCGA Pan-Cancer Analysis of Whole Genomes - Relationships Between Germline and Somatic Mutations February 6, 2017
Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum: A National Cancer Policy Forum Workshop February 13-14, 2017 Washington, DC
Approaches to Blue Ribbon Panel Recommendations - The Case of Lynch Syndrome February 22-23, 2017 Rockville, MD
CBIIT Speaker Series: Building NLP Processes for Automated Extraction of Data from Clinical Reports March 1, 2017
SeqSPACE Webinar Series: Title TBD March 9, 2017
Workshop on Next Steps in Studying Human Microbiome and Health in Prospective Studies March 14-15, 2017 Rockville, MD
American Association for Cancer Research Annual Meeting April 1-5, 2017 Washington, DC Note: The AACR Molecular Epidemiology Working Group is accepting applications from molecular epidemiology consortia for meeting space. Applications will be accepted through March 24, 2017. View announcement.
2017 Sandpit Workshop: Knowledge Integration Across Health Domains, Professions, and Nations to Advance Cancer Prevention April 24-26, 2017 Applications must be emailed to NCI-CRUK-Sandpit2017@mail.nih.gov by February 15, 2017, at 6:00 p.m. ET.
2017 NIH Regional Seminar May 3-5, 2017 New Orleans, LA
The 4th Ethical, Legal, and Social Implications Congress - Genomics and Society: Expanding the ELSI Universe June 5-7, 2017 Farmington, CT
BD2K Guide to the Fundamentals of Data Science Webinar Series Every Friday, 12:00-1:00 p.m. ET
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The Epidemiology and Genomics Research Program (EGRP) in the Division of Cancer Control and Population Sciences (DCCPS) funds research in human populations to understand the causes of cancer and related outcomes.
The Program fosters interdisciplinary collaborations, as well as the development and use of resources and technologies to advance cancer research and translation of this research, which serve as the basis for clinical and public health interventions. |
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Each year, staff in the Epidemiology and Genomics Research Program (EGRP) nominate and vote for manuscripts published by EGRP grantees that are deemed to have the greatest potential scientific and/or public health impact. The following publications were chosen for inclusion in the
2016 Research Highlights:
Breast Cancer
Colorectal Cancer
- Nomura SJO, Dash C, Rosenberg L, Yu J, Palmer JR, Adams-Campbell LL. Is Adherence to Diet, Physical Activity, and Body Weight Cancer Prevention Recommendations Associated with Colorectal Cancer Incidence in African American Women? Cancer Causes Control. 2016 Jul;27(7):869-79.
- Cespedes-Feliciano EM, Kroenke CH, Meyerhardt JA, Prado CM, Bradshaw PT, Dannenberg AJ, Kwan ML, Xiao J, Quesenberry C, Weltzien EK, Castillo AL, Caan BJ. Metabolic Dysfunction, Obesity, and Survival Among Patients With Early-Stage Colorectal Cancer. J Clin Oncol. 2016 Oct;34(30):3664-3671.
Head and Neck Cancer
- Agalliu I, Gapstur S, Chen Z, Wang T, Anderson RL, Teras L, Kreimer AR, Hayes RB, Freedman ND, Burk RD. Associations of Oral α-, β-, and γ-Human Papillomavirus Types With Risk of Incident Head and Neck Cancer. JAMA Oncol. 2016 Jan;2(5):599-606.
Multiple Cancers
- Amos CI, Dennis J, Wang Z, Byun J, Schumacher FR, Gayther SA, Casey G, Hunter DJ, Sellers TA, Gruber SB, Dunning AM, Michailidou K, Fachal L, Doheny K, Spurdle AB, Li Y, Xiao X, Romm J, Pugh E, Coetzee GA, Hazelett DJ, Bojesen SE, Caga-Anan C, Haiman CA, Kamal A, Luccarini C, Tessier D, Vincent D, Bacot F, Van Den Berg DJ, Nelson S, Demetriades S, Goldgar DE, Couch FJ, Forman JL, Giles GG, Conti DV, Bickeböller H, Risch A, Waldenberger M, Brüske-Hohlfeld I, Hicks BD, Ling H, McGuffog L, Lee A, Kuchenbaecker K, Soucy P, Manz J, Cunningham JM, Butterbach K, Kote-Jarai Z, Kraft P, FitzGerald L, Lindstrom S, Adams M, McKay JD, Phelan CM, Benlloch S, Kelemen LE, Brennan P, Riggan M, O'Mara TA, Shen H, Shi YY, Thompson DJ, Goodman MT, Nielsen SF, Berchuck A, Laboissiere S, Schmit SL, Shelford T, Edlund CK, Taylor JA, Field JK, Park SK, Offit K, Thomassen M, Schmutzler R, Ottini L, Hung RJ, Marchini J, Amin A, Olama A, Peters U, Eeles RA, Seldin MF, Gillanders E, Seminara D, Antoniou AC, Pharoah PD, Chenevix-Trench G, Chanock SJ, Simard J, Easton DF. The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):126-135.
Pediatric Cancer
- Bhakta N, Liu Q, Yeo F, Baassiri M, Ehrhardt MJ, Srivastava DK, Metzger ML, Krasin MJ, Ness KK, Hudson MM, Yasui Y, Robison LL. Cumulative Burden of Cardiovascular Morbidity in Paediatric, Adolescent, and Young Adult Survivors of Hodgkin's Lymphoma: An Analysis from the St Jude Lifetime Cohort Study. Lancet Oncol. 2016 Sep;17(9):1325-34.
- Marcotte EL, Thomopoulos TP, Infante-Rivard C, Clavel J, Petridou ET, Schüz J,Ezzat S, Dockerty JD, Metayer C, Magnani C, Scheurer ME, Mueller BA, Mora AM, Wesseling C, Skalkidou A, Rashed WM, Francis SS, Ajrouche R, Erdmann F, Orsi L, Spector LG. Caesarean Delivery and Risk of Childhood Leukaemia: A Pooled Analysis from the Childhood Leukemia International Consortium (CLIC). Lancet Haematol. 2016 Apr;3(4):e176-85.
Skin Cancer
Survivorship
- Chow EJ, Cushing-Haugen KL, Cheng GS, Boeckh M, Khera N, Lee SJ, Leisenring WM, Martin PJ, Mueller BA, Schwartz SM, Baker KS. Morbidity and Mortality Differences Between Hematopoietic Cell Transplantation Survivors and Other Cancer Survivors. J Clin Oncol. Epub 2016 Nov 21.
- Henderson TP, Moskowitz CS, Chou JF, Bradbury AR, Neglia JP, Dang CT, Onel K, Friedman DN, Bhatia S, Strong LC, Stovall M, Kenney LB, Barnea D, Lorenzi E, Hammond S, Leisenring WM, Robison LL, Armstrong GT, Diller LR, Oeffinger KC. Breast Cancer Risk in Childhood Cancer Survivors Without a History of Chest Radiotherapy: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2016 Mar 20;34(9):910-8.
Congratulations to all of our grantees! More details about the current and past Research Highlights publications can be found on the EGRP website.
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How Can NCI's Genomic Data Commons and Cancer Genomics Cloud Pilots Foster Data Sharing and Advance Cancer Research?
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The Genomic Data Commons (GDC) Supports Data Sharing
Cancer Genomics Cloud Pilots Bring Data and Computation Together to Accelerate Cancer Research
NCI's Center for Biomedical Informatics and Information Technology (CBIIT), in collaboration with the Center for Cancer Genomics, awarded three contracts for the Cancer Genomics Cloud (CGC) Pilots. The Broad Institute, the Institute for Systems Biology, and Seven Bridges Genomics have each developed unique infrastructures with a variety of tools to access, explore, and analyze molecular data. The CGC Pilots allow users to run best practice tools and pipelines already implemented, or upload their own data and/or analysis methods to workspaces.
Learn more about the three Pilot platforms.
These pilots are designed to explore innovative methods for accessing and computing on large scale cancer genomic data. They bring analytics and data from TCGA together on a single platform through a set of data repositories with co-located computational capacity and an Application Programming Interface (API) that provides secure data access. In this model, applications are brought to the data, rather than bringing the data to the applications. (
See handout.) As an example, data for the
ICGC-TCGA DREAM Somatic Mutation Calling Challenge - RNA is currently being hosted on the Institute for Systems Biology and Seven Bridges Genomics clouds.
The Cancer Genomics Cloud Pilots Are Available for Researchers to Use!
NCI encourages the research community to test the usefulness of the CGC Pilots in their own research. To get started, users need to register and establish an account with each Pilot of interest. TCGA data is available on all three platforms after users agree to the data use restrictions and requirements outlined in the
TCGA publication guidelines. Anyone interested in working with controlled access data on any of the cloud platforms will need
dbGaP Access. Cloud pilot projects to date have included publicly accessible (e.g., TCGA) or investigator-generated datasets; analysis of germline and/or somatic alterations; and data from whole exome, whole genome, or RNA sequencing platforms.
More Information
NCI will be hosting a
webinar on February 2, 2017 for those interested in learning more about querying and downloading data using the GDC Data Portal and the Data Transfer Tool.
View answers to frequently asked questions
about the CGC Pilot projects. For questions, ideas, and suggestions about the Cancer Genomics Cloud Pilot Program, e-mail
ncicloud@nih.gov.
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