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Welcome

Elizabeth Blackburn
Science never stops. The holiday season has certainly not slowed the flow of discoveries being made at the Salk Institute. In the last month, the Institute has had a series of exciting breakthroughs in microproteins, aging, ribosomes, immune cells and plant biology from the labs of Alan Saghatelian, Jan Karlseder, Dmitry Lyumkis, Björn Lillemeier, Juan Carlos Izpisua Belmonte and Joe Ecker.
 
Salk faculty have been busy in other ways, too, including Janelle Ayres and Tom Albright delivering TEDx San Diego talks, and Ron Evans and Diana Hargreaves receiving national recognition for their work. We also welcome Ted Waitt as the Institute's newly installed board chairman and incoming faculty Wolfgang Busch and Edward Stites.
 
Please read on for more information.

Yours in Discovery,



Elizabeth Blackburn
Ted Waitt named chairman of Board of Trustees

Ted Waitt
Ted Waitt, chairman of the Waitt Foundation and cofounder of Gateway, Inc., a pioneer in the direct marketing of personal computers, has been named chairman of the Salk Institute for Biological Studies' Board of Trustees. A native of Sioux City, Iowa, Waitt attended the universities of Colorado and Iowa and received an honorary doctorate of science from the University of South Dakota. He has earned a number of honors, including being appointed by Congress to serve on the Advisory Commission on Electronic Commerce. He retired from Gateway in 2004 and has devoted his time and resources to philanthropy since then. Waitt has four grown children and resides in Southern California with his wife, Michele.

New approach reverses aging in human cells and mice

Salk Scientists Reverse Signs of Aging video

Juan Carlos Izpisua Belmonte laboratory
Juan Carlos Izpisua Belmonte has published a paper in Cell that is garnering a lot of media attention. The research  details a cellular reprogramming approach that rejuvenated organs and helped animals live longer.

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Tiny protein has big role in biology

Alan Saghatelian and collaborators shared work in  Nature Chemical Biology about their discovery of a microprotein with a key role in cellular cleanup. The new molecule could provide a better understanding of how levels of genes, including disease genes, are controlled in the cell.

 
Telomeres experience a Goldilocks effect

Immunofluorescence analysis of pluripotent markers Nanog _red_ and TRA-1-60 _green_
Jan Karlseder's lab published research in
Nature Structural & Molecular Biology explaining that, for stem cells to be healthy, telomere length can't be too short or too long, but "just right." The finding provides insights into advancing stem cell-based therapies, especially related to aging and regenerative medicine.


Immune cells amplify signals from invaders

Immune receptors
Björn Lillemeier's lab detailed the process by which a single particle from a harmful intruder immediately kicks immune T cells into action, launching a larger immune response. The discovery, published in
Nature Immunology, could help scientists design better immune-mediated treatments for cancer or autoimmune diseases.

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Collaboration reveals how molecular machines
take shape
Dmitry Lyumkis

Dmitry Lyumkis and The Scripps Research Institute deployed cutting-edge imaging methods and analysis tools to decipher how complex molecular machines called ribosomes assemble, a first step in understanding their roles in health and disease. The work was published in  Cell.

Other News

Salk welcomes two new faculty, leaders in plant biology and cancer research
Wolfgang Busch and Edward Stites

Wolfgang Busch, whose appointment begins on March 31, 2017, joins the Institute as  an associate professor in the Plant Molecular and Cellular Biology Laboratory. Busch uses a systems genetics approach to understand how root growth in given environments is determined by a plant's genes.
 
Edward Stites will join the Integrative Biology Laboratory as an assistant professor in January 2017. He  is a physician-scientist who uses both experimental and computational techniques  in order to develop a new generation of precision therapies that can better target cancers.
 
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Ronald Evans named a Fellow of National Academy of Inventors

Ron Evans
Ronald Evans has been selected as one of 175 leaders in academic invention by the National Academy of Inventors. According to the NAI public announcement, "Being elected to NAI Fellow status is the highest professional distinction accorded solely to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and welfare of society."

On April 6, 2017, the 2016 NAI Fellows will be inducted as part of the Sixth Annual Conference of the National Academy of Inventors at the John F. Kennedy Presidential Library & Museum in Boston, Massachusetts.

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Diana Hargreaves garners V Foundation award

Diana Hargreaves
Diana Hargreaves, an assistant professor in Salk's Molecular and Cell Biology  Laboratory and member of the Salk Cancer Center, has received a V Scholar Grant from the V Foundation for Cancer Research. The two-year grant of $100,000 per year supports young tenure-track faculty early in their cancer research careers. The award supports Hargreaves' investigation of gene mutations in ovarian cancer with the ultimate goal of finding new strategies to the disease.

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Scientists share insights into plants' stress response
Media coverage:
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Members of Joseph Ecker's lab appeared on KPBS to describe their discovery of molecular conductors that help plants orchestrate a response to drought and other environmental stressors.


Janelle Ayres and Tom Albright featured in
TEDx San Diego
Salk faculty  Janelle Ayres  and  Tom Albright  spoke about their research at the seventh annual TEDx San Diego on October 22 at Copley Symphony Hall.
Janelle Ayres and Tom Albright

TedEx video graphic

Events

The Salk Science & Music Series continues its fourth season with a concert by cellist Amit Peled at 4:00 p.m. Sunday, January 22 in the Conrad T. Prebys Auditorium. Comprising the science component of the afternoon, Salk Assistant Professor  Kenta Asahina of the Molecular Neurobiology Laboratory will discuss his research. Visit www.salk.edu/music.
  • January 22, 2017 - Amit Peled with Kenta Asahina
  • February 12, 2017 - Sean Chen & Karen Joy Davis with Saket Navlakha
  • March 12, 2017 - Zlata Chochieva with Eiman Azim
  • April 30, 2017 - Helen Sung Quartet with Nicola Allen
Salk courtyard
Louis Kahn - The power of architecture ONE MONTH LEFT

The San Diego Museum of Art in Balboa Park features the first retrospective in two decades of Salk architect Louis Kahn's work, featuring more than 200 objects related to his buildings and projects. On display through January 31, 2017, the exhibit will be accompanied by a series of programs and events dedicated to exploring the architectural significance of his work in the 20th century.
Two in-depth reviews in the Los Angeles Times lauded architect Louis Kahn and his masterwork, the Salk Institute.
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