UC Davis School of Veterinary Medicine
VETERINARY CENTER FOR CLINICAL TRIALS
Clinical Trials Report
September 2016
NEW CLINICAL TRIALS
Assessing the Outcomes and Utilizing New Techniques for Stent Placement in Dogs with Prostatic, Bladder or Urethral Cancer

Cancer resulting in obstruction of the lower urinary tract of dogs is most commonly found in the prostate, urinary bladder and urethra often results in complete blockage of the urethra, causing a patient to be unable to pass urine.  The purpose of this study is to evaluate the efficacy of using transrectal ultrasound for stent placement in dogs.

FEATURED ONGOING CLINICAL TRIALS
Dissolving Bladder Stones via Diet in Dogs

We hope to provide another option to struvite stone dissolution in dogs. The purpose of this trial is to evaluate the efficacy of a therapeutic diet for struvite dissolution in dogs.
Assessing a Potential Treatment for Mast Cell Tumors

Although it is generally recommended as the first step in treatment of mast cell tumors, surgery is not always possible. Treatment with steroids, chemotherapy or targeted therapies (e.g., Masitinib) may be beneficial in controlling the disease. The objective of the study is to evaluate the anti-cancer effects of Masitinib in comparison to a placebo in dogs with grade 2 or 3 mast cell tumors that have not been previously removed or treated with chemotherapy or radiation.

Identifying the Genetics Behind Ventricular Septal Defects in Arabian Horses

Ventricular Septal Defects (VSDs) are the most common congenital heart defects in horses and allow blood to shunt inappropriately from the left ventricle to the right ventricle via an opening in the ventricular septum. This blood recirculates through the lungs and left chambers, resulting in enlargement of these structures. Arabian horses are overrepresented in horses presenting for VSDs, and we are investigating the possibility of a genetic predisposition for this defect.

Improving Diagnostic Values for Cushing's Disease in Dogs

The cut off values previously used to diagnose Cushing's disease, were first determined over 30 years ago. Since then, there have been significant advancements in laboratory equipment and techniques as well as the clinician's ability to identify this disease as a differential diagnosis. The goal of this study is to re-evaluate the cut off values used to diagnose hyperadrenocorticism in dogs.
Identifying the Genetics Behind Ectopic Ureters in Golden Retrievers, Labrador Retrievers, Newfoundlands and Siberian Huskies

Sometimes when a puppy is developing during embryogenesis, the ureters do not connect properly into the bladder, leading to ectopic ureters.  We propose to identify the region of the dog genome associated with ectopic ureters.

Assessing Use of Cone Beam Computed Tomography for Dental Disease in Cats

Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for mesaticephalic and brachycephalic cats with dental disorders.
Understanding the Genetics Behind Cleft Lip and/or Palate in Dogs

Cleft lip and/or cleft palate are developmental defects that result in the failure of the roof of the mouth to properly form. The aim of this study is to identify the genes responsible for these birth defects and prevent them in future litters.

TRIAL UPDATES
Clinical Trials that are "On Hold" 
  • Laser Ablation for Treatment of Ectopic Ureters in Dogs
  • Stem Cell Therapy for Dogs with Acute Severe Spinal Cord Injury
  • Plasmid IL-12 + Electroporation Treatment for Soft Tissue Sarcoma in Dogs
  • Biomarkers of B-cell Lymphoma in Dogs
NOTE: Trials that are "On Hold" are not accepting new patients and we do not know when these trials will open back up.  If/when these trials do accept new patients again, we will notify you via this report and post information about the study (including contact information) on the VCCT website.

 
Clinical Trials that are Recently Completed or Finished Enrollment
  • Assessing Upper Airway Syndrome in Norwich Terriers
  • Assessing Two Medications for Osteoarthritis in Dogs
  • Evaluating a Treatment for Feline Infectious Peritonitis
  • Radioimmunotherapy for Metastatic Sarcomas and Melanomas in Dogs
  • Effect of Sotalol on Heart Function and Rhythm in Dogs with Ventricular Arrhythmias
THANK YOU!
Thank you for wanting to be a part of our clinical trials program.  We greatly appreciate your desire to participate in and inform others about our trials, and/or refer cases to the Veterinary Medical Teaching Hospital (VMTH).  The VCCT and our clinical trials wouldn't be here without you!  
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