UC Davis School of Veterinary Medicine
VETERINARY CENTER FOR CLINICAL TRIALS
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Healthy Dogs - Assessing Amino Acid Concentrations in Urine
Amino acids are the building blocks of protein. We are trying to establish normal reference ranges for urinary amino acids in healthy dogs consuming dry, canned or commercial raw diets or home-prepared diets.
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Ocular Squamous Cell Carcinoma -Understanding the Genetics in Haflinger, Beligan, Percheron, Appaloosa and Arabians Horses
Squamous cell carcinoma (SCC) is one of the most common forms of cancer to affect the eye and affects Haflingers, Belgians, Percherons, Appaloosas, and Arabians (among others). The objective of this study is to determine the incidence of SCC in the listed breeds, understand the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.
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FEATURED ONGOING CLINICAL TRIALS
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Osteosarcoma - Assessing a New Addition to Treatment in Dogs
Standard therapy for dogs diagnosed with osteosarcoma has long been amputation of the affected limb followed by chemotherapy to prevent the spread of cancer. Rapamycin is a drug that potentially can inhibit the mTOR pathway. The purpose of this study is to determine if adding Rapamycin into the treatment protocol for dogs with osteosarcoma will be safe and improve efficacy of current standard therapies for osteosarcoma in dogs.
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Oral Melanoma - Treating and Identifying the Disease in Dogs (2 trials)
Trial #1 is assessing a new treatment to carry oxygen to the tumor to hopefully make it more responsive to treatment.
Trial #2 aims to determine whether lymph node palpation, CT scan, combined PET/CT scan are the most reliable methods for identifying metastatic lymph nodes.
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Liver Tumors - Using a New Technique to Shrink Tumors in Dogs
When liver tumors in dogs cannot be removed with surgery, treatment options are limited or non-existent. In humans, one of the standard treatments for those cases is transarterial embolization (TAE), which eliminates the blood supply of the tumor and may decrease tumor size. Therefore, the objectives of this study are to 1) describe the procedure of TAE in dogs with naturally-occurring liver cancer, and 2) evaluate the effect that liver TAE has on clinical signs and the size of the tumor.
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Atrial Fibrillation - Understanding the Genetics in Irish Wolfhounds
Atrial fibrillation (AF) is an arrhythmia in which the heart beats fast with no identifiable pattern of atrial activation. Although AF affects a wide variety of animals, it has a particularly high prevalence in Irish Wolfhounds suggesting a genetic predisposition. We are conducting a genetic investigation into the cause of AF in Irish Wolfhounds in order to improve our understanding of this disease and thus inform prevention and treatment practices.
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Ectopic Ureters - Identifying the Genetics in Golden Retrievers, Labrador Retrievers, Newfoundlands and Siberian Huskies
Sometimes when a puppy is developing during embryogenesis, the ureters do not connect properly into the bladder, leading to ectopic ureters. We propose to identify the region of the dog genome associated with ectopic ureters.
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Old Age/Longevity - Understanding the Genetics in Large Breed Dogs
Many current studies are aimed at trying to identify genes associated with diseases in dogs, but we are looking to see if genes exist that could help protect against these same life-limiting diseases in the dog.
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Hypothyroidism - Evaluating Current Treatment Strategies in Dogs
Thyroid hormone supplementation is the treatment of choice for hypothyroidism. Recent clinical experience suggests that some dogs may respond to lower doses of thyroid hormone supplementation. We are currently investigating whether dogs with hypothyroidism can be successfully treated using a lower dose of thyroid hormone and the best way to monitor this treatment.
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Lymphoma - Investigating a New Treatment for Dogs
Fermented wheat germ proteins (FWGP) has been shown to be a potent immune modulator that could activate immune cells called Natural Killer (NK) cells. The purpose of this trial is to determine if FWGP promotes anti-cancer immunity and to evaluate the safety and efficacy of the FWGP product when administered orally in dogs with lymphoma.
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Nasolacrimal Apparatus Blockage - A Multi-Disciplinary, Minimally-Invasive Treatment in Dogs
The nasolacrimal apparatus (NLA) frequently becomes blocked and sometimes infected leading to discomfort, tear staining, eye discharge, skin inflammation, and a decreased quality of life. Using a team of specialists with expertise in Ophthalmology, Internal Medicine, Endoscopy, Diagnostic Imaging, and Interventional Radiology, we have utilized fluoroscopy to successfully treat NLA obstruction in dogs. The purpose of this study is to recruit and treat more cases and to evaluate more objective outcome measures.
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Sudden Blindness - Comparing Disease Assessment Tools in Dogs
Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of permanent blindness in dogs, for which the underlying cause for SARDS is unknown. The purpose of this trial is to better understanding this disease, especially how it changes over time.
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Elbow Dysplasia - Assessing a New Diagnostic Tool in Dogs
It is essential that clinicians accurately identify and diagnose the different lesions in the joint to make appropriate decisions about how best to treat elbow dysplasia and predict surgical outcome. Therefore, the purpose of this study is to evaluate the use of a micro-invasive arthroscope system for the diagnosis of elbow dysplasia in dogs.
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Cancer of the Prostate, Bladder and/or Urethra - Treating or Assessing the Diseases in Dogs (3 trials)
Trial #1
focuses on evaluating the efficacy of transrectal ultrasound
during urethral stent placement
to circumvent problems commonly associated with fluoroscopic guidance.
Trial #2 aims to describe the procedure of prostatic artery embolization and evaluate the effect that this technique has on clinical signs and tumor size in dogs with prostate cancer.
Trial #3
focuses on determining whether 1) it is possible to obtain useful bacterial culture samples from prostates in dogs with prostate cancer and 2) if results of these cultures correlate with urine cultures collected directly from the bladder.
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Clinical Trials that are "On Hold"
- Identifying Lymph Node Metastasis in Dogs with Lung Tumors
- Assessing Minimally-Invasive Tumor Ablation in Cats and Dogs
- Improving Operative Detection of Tumors in Cats and Dogs
- Sentinel Lymph Node Mapping in Dogs
- Assessing a New Therapy for Cats with Diabetes Mellitus
- Evaluating a Novel Formulation of Chemotherapy for Dogs with Lymphoma
- Assessing a Potential Treatment for Mast Cell Tumors in Dogs
- Evaluating a Stem Cell Therapy for Inflammatory Bowel Disease
- Laser Ablation for Treatment of Ectopic Ureters in Dogs
- Stem Cell Therapy for Dogs with Acute Severe Spinal Cord Injury
NOTE: Trials that are "On Hold" are not accepting new patients and we do not know when these trials will open back up. If/when these trials do accept new patients again, we will notify you via this report and post information about the study (including contact information) on the VCCT website.
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Clinical Trials that are Recently Completed or Finished Enrollment
- Finding the Best Collection Method for Infectious Keratitis in Cats, Dogs and Horses
- Chronic Progressive Lymphedema in Friesian Horses
- Use of Tanovea-CA1 in Dogs with Lymphoma, Multiple Myeloma or Lymphoid Leukemia
- Plasmid IL-12 + Electroporation Treatment for Soft Tissue Sarcoma in Dogs
- Sentinel Lymph Node Mapping in Dogs with Mast Cell Tumors
- Treating Foals with Neonatal Maladjustment Syndrome with the Madigan Assisted Squeeze Technique
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Thank you for wanting to be a part of our clinical trials program. We greatly appreciate your desire to participate in and inform others about our trials, and/or refer cases to the Veterinary Medical Teaching Hospital (VMTH). The VCCT and our clinical trials wouldn't be here without you!
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